S Cauchi, D Meyre, C Dina, H Choquet, C … - Diabetes, 2006 - Am Diabetes Assoc Recently, the transcription factor 7-like 2 (TCF7L2) gene has been associated
with type 2 diabetes in subjects of European origin in the DeCode study. We
genotyped the two most associated variants (rs7903146 and rs12255372) in ... Cited by 149 - Related articles - BL Direct - All 3 versions
- ►biologists.org PW Heiser, J Lau, MM Taketo, PL Herrera, M … - Development, 2006 - dev.biologists.org A recent study has shown that deletion of ß-catenin within the pancreatic
epithelium results in a loss of pancreas mass. Here, we show that ectopic
stabilization of ß-catenin within mouse pancreatic epithelium can have ... Cited by 57 - Related articles - BL Direct - All 5 versions
BZ Stanger, AJ Tanaka, DA Melton - Nature, 2007 - nature.com The determinants of vertebrate organ size are poorly understood, but the process
is thought to depend heavily on growth factors and other environmental cues. In
the blood and central nervous system, for example, organ mass is determined ... Cited by 56 - Related articles - BL Direct - All 6 versions
- ►nih.gov SA Schäfer, O Tschritter, F Machicao, C Thamer … - Diabetologia, 2007 - Springer Page 1. ARTICLE Impaired glucagon-like peptide-1-induced insulin secretion in carriers
of transcription factor 7-like 2 (TCF7L2) gene polymorphisms ... Cited by 54 - Related articles - BL Direct - All 9 versions
- ►nih.gov RJF Loos, PW Franks, RW Francis, I Barroso, … - Diabetes, 2007 - Am Diabetes Assoc Rapidly accumulating evidence shows that common T-cell transcription factor
(TCF)7L2 polymorphisms confer risk of type 2 diabetes through unknown
mechanisms. We examined the association between four TCF7L2 single ... Cited by 53 - Related articles - BL Direct - All 8 versions
JM Wells, F Esni, GP Boivin, BJ Aronow, W … - BMC developmental biology, 2007 - biomedcentral.com Pdx1-cre floxed β-catenin animals were viable but demonstrated small body size
and shortened median survival. The pancreata from knockout mice were hypoplastic
and histologically demonstrated a striking paucity of exocrine pancreas, ... Cited by 36 - Related articles - Cached - All 9 versions
- ►jbc.org Z Liu, JF Habener - Journal of Biological Chemistry, 2008 - ASBMB The insulinotropic hormone GLP-1 (glucagon-like peptide-1) is a new therapeutic
agent that preserves or restores pancreatic beta cell mass. We report that GLP-1
and its agonist, exendin-4 (Exd4), induce Wnt signaling in pancreatic beta ... Cited by 34 - Related articles - All 4 versions
U Smith - Diabetologia, 2007 - Springer The initial report by Grant et al. [1] that variants in the TCF7L2 gene are
strongly associated with risk of developing type 2 diabetes has now been
robustly reproduced in many other populations. In fact, variants in this ... Cited by 30 - Related articles - All 3 versions
- ►oxfordjournals.org C Haumaitre, M Fabre, S Cormier, C Baumann … - Human molecular genetics, 2006 - Oxford Univ Press Heterozygous mutations in the HNF1ß/vHNF1/TCF2 gene cause maturity-onset
diabetes of the young (MODY5), associated with severe renal disease and abnormal
genital tract. Here, we characterize two fetuses, a 27-week male and a ... Cited by 29 - Related articles - BL Direct - All 6 versions
- ►shouxi.net R Mussmann, M Geese, F Harder, S Kegel, U … - Journal of Biological Chemistry, 2007 - ASBMB Recent developments indicate that the regeneration of beta cell function and
mass in patients with diabetes is possible. A regenerative approach may
represent an alternative treatment option relative to current diabetes ... Cited by 29 - Related articles - All 7 versions
