- ►nih.gov M Prentki, CJ Nolan - Journal of Clinical Investigation, 2006 - Am Soc Clin Investig The major focus of this Review is on the mechanisms of islet β cell failure in the pathogenesis
of obesity-associated type 2 diabetes (T2D). As this demise occurs within the context of β cell
compensation for insulin resistance, consideration is also given to the mechanisms ... Cited by 199 - Related articles - BL Direct - All 7 versions
- ►pubget.com [PDF] DR Laybutt, AM Preston, MC Åkerfeldt, JG Kench, AK … - Diabetologia, 2007 - Springer Page 1. ARTICLE Endoplasmic reticulum stress contributes to beta cell apoptosis
in type 2 diabetes DR Laybutt & AM Preston & MC Åkerfeldt & JG Kench & AK Busch
& AV Biankin & TJ Biden Received: 21 September 2006 ... Cited by 105 - Related articles - BL Direct - All 5 versions
- ►endojournals.org V Poitout, RP Robertson - Endocrine reviews, 2008 - Endocrine Soc Glucotoxicity, lipotoxicity, and glucolipotoxicity are secondary phenomena that are proposed
to play a role in all forms of type 2 diabetes. The underlying concept is that once the primary pathogenesis
of diabetes is established, probably involving both genetic and environmental forces, ... Cited by 71 - Related articles - BL Direct - All 7 versions
- ►diabetesjournals.org JB Flowers, ME Rabaglia, KL Schueler, MT Flowers, H … - Diabetes, 2007 - Am Diabetes Assoc The lipogenic gene stearoyl-CoA desaturase (SCD)1 appears to be a promising new target for
obesity-related diabetes, as mice deficient in this enzyme are resistant to diet- and leptin
deficiency–induced obesity. The BTBR mouse strain replicates many features of insulin ... Cited by 33 - Related articles - BL Direct - All 5 versions
- ►physiology.org SM Turpin, GI Lancaster, I Darby, MA … - American Journal of …, 2006 - Am Physiological Soc Fatty acid-induced apoptosis occurs in pancreatic -cells and contributes to the metabolic
syndrome. Skeletal muscle insulin resistance is mediated by fatty acid oversupply, which also
contributes to the metabolic syndrome. Therefore, we examined whether fatty acids ... Cited by 23 - Related articles - BL Direct - All 3 versions
- ►physiology.org E Lai, G Bikopoulos, MB Wheeler, M … - American Journal of …, 2008 - Am Physiological Soc Chronic exposure to elevated saturated free fatty acid (FFA) levels has been shown to induce
endoplasmic reticulum (ER) stress that may contribute to promoting pancreatic β-cell
apoptosis. Here, we compared the effects of FFAs on apoptosis and ER stress in human ... Cited by 19 - Related articles - BL Direct - All 3 versions
Y Wei, D Wang, MJ Pagliassotti - Molecular and Cellular Biochemistry, 2007 - Springer Abstract Lipid accumulation in non-adipose tissues leads to cell dysfunction and apoptosis, a
phenomenon known as lipotoxicity. Recent evidence suggests that lipotoxicity in hepatocytes
involves endoplasmic reticulum (ER) stress and c-Jun NH 2 -terminal kinase-mediated ... Cited by 19 - Related articles - BL Direct - All 3 versions
SC Martinez, K Tanabe, C Cras-Méneur, NA Abumrad, … - Diabetes, 2008 - Am Diabetes Assoc RESULTS—Increasing fatty acid concentrations (100–400 μmol/l palmitate or oleate) led to early
Jun NH 2 -terminal kinase (JNK) activation that preceded induction of ER stress markers and
apoptosis. Foxo1 activity was increased with fatty acid administration and by ... Cited by 15 - Related articles - BL Direct - All 4 versions
- ►endojournals.org M Prentki, SR Madiraju - Endocrine reviews, 2008 - Endocrine Soc GL/FFA cycle is referred to as a "futile" cycle because it involves continuous formation and hydrolysis
of GL with the release of heat, at the expense of ATP. However, we present evidence underscoring
the "vital" cellular signaling roles of the GL/FFA cycle for many biological processes. ... Cited by 14 - Related articles - All 5 versions
