- ►diabetesjournals.org MN Weedon, B Shields, G Hitman, M Walker, … - Diabetes, 2006 - Am Diabetes Assoc Ectoenzyme nucleotide pyrophosphate phosphodiesterase 1 (ENPP1) is an inhibitor
of insulin-induced activation of the insulin receptor. There is strong evidence
from several previous studies that a common coding variant of ENPP1 (K121Q) ... Cited by 48 - Related articles - BL Direct - All 5 versions
- ►diabetesjournals.org HN Lyon, JC Florez, T Bersaglieri, R Saxena, … - Diabetes, 2006 - Am Diabetes Assoc The common missense single nucleotide polymorphism (SNP) K121Q in the ectoenzyme
nucleotide pyrophosphate phosphodiesterase (ENPP1) gene has recently been
associated with type 2 diabetes in Italian, US, and South-Asian ... Cited by 48 - Related articles - BL Direct - All 7 versions
- ►oxfordjournals.org H Freeman, RD Cox - Human molecular genetics, 2006 - Oxford Univ Press Diabetes is one of the most challenging health problems of the 21st century with
an alarming increase in the prevalence of type-2 diabetes mellitus (T2DM) and
associated conditions such as hypertension, dyslipidemias and obesity. T2DM ... Cited by 48 - Related articles - BL Direct - All 8 versions
- ►diabetesjournals.org CJ Willer, LL Bonnycastle, KN Conneely, WL … - Diabetes, 2007 - Am Diabetes Assoc More than 120 published reports have described associations between single
nucleotide polymorphisms (SNPs) and type 2 diabetes. However, multiple studies
of the same variant have often been discordant. From a literature search, ... Cited by 43 - Related articles - BL Direct - All 6 versions
YY Zhang, L Gottardo, R Thompson, C Powers, … - Obesity, 2006 - nature.com Visfatin (also known as pre-B cell colony-enhancing factor, or PBEF) is a
pro-inflammatory adipokine expressed predominantly in visceral fat. We
investigated whether polymorphisms at the visfatin/PBEF locus influence the ... Cited by 36 - Related articles - All 4 versions
- ►endojournals.org Y Bottcher, A Korner, T Reinehr, B Enigk, W … - Journal of Clinical Endocrinology & Metabolism, 2006 - Endocrine Soc Results: We identified a significantly increased risk of obesity in Leipzig
children carrying the 121Q variant (adjusted odds ratio, 1.82; 95% confidence
interval, 1.30–2.56; P = 0.0005) or the [Q-delT-G] haplotype [1.75 ... Cited by 34 - Related articles - All 6 versions
- ►tokushima-u.ac.jp [PDF] P Keshavarz, H Inoue, Y Sakamoto, K Kunika, … - Journal of Human Genetics, 2006 - Springer Abstract Ecto-nucleotide pyrophosphatase/phosphodi- esterase 1 (ENPP1, also
known as PC-1) inhibits insulin signal transduction pathway(s). Previous studies
have demonstrated the K121Q variant of the ENPP1 gene to have a significant ... Cited by 29 - Related articles - BL Direct - All 9 versions
SK Das, SC Elbein - Cellscience, 2006 - pubmedcentral.nih.gov Type 2 Diabetes results from a complex physiologic process that includes the
pancreatic beta cells, peripheral glucose uptake in muscle, the secretion of
multiple cytokines and hormone-like molecules from adipocytes, hepatic ... Cited by 25 - Related articles - All 3 versions
D Meyre, N Bouatia-Naji, V Vatin, J Veslot, C … - Diabetologia, 2007 - Springer Abstract Aims/hypothesis We assessed the predictive value of ectonu- cleotide
pyrophosphatase/phosphodiesterase 1 gene (ENPP1) SNPs with regard to the risk of
developing obesity and/or type 2 diabetes in a large French general ... Cited by 20 - Related articles - BL Direct - All 3 versions
- ►smajournalonline.org ZH Israili, B Lyoussi, R Hernandez- … - American journal of therapeutics, 2007 - journals.lww.com Metabolic syndrome (MetSyndr), a constellation of abnormalities [obesity,
glucose intolerance, insulin resistance (IR), dyslipidemia (low HDL-cholesterol,
high LDL-cholesterol and triglycerides (TG)], and elevated blood pressure ... Cited by 17 - Related articles - BL Direct - All 7 versions
