E Suviolahti, HE Lilja, P Pajukanta - Annals of Medicine, 2006 - informahealthcare.com Familial combined hyperlipidemia (FCHL) constitutes a substantial risk factor for atherosclerosis
since it is observed in about 20% of coronary heart disease (CHD) patients under 60 years.
FCHL, characterized by elevated levels of total cholesterol (TC) and triglycerides (TGs), or ... Cited by 22 - Related articles - BL Direct - All 7 versions
J Naukkarinen, C Ehnholm, L Peltonen - Current opinion in lipidology, 2006 - journals.lww.com Recent findings: The first locus for familial combined hyperlipidemia on 1q21-23 revealed a gene
encoding a transcription factor critical in lipid and glucose metabolism, USF1. All the associated
variants represent noncoding single nucleotide polymorphisms, one of which affects the ... Cited by 20 - Related articles - BL Direct - All 8 versions
K Kantartzis, A Fritsche, F Machicao, M Stumvoll, J … - Journal of Molecular …, 2007 - Springer Abstract Upstream transcription factor 1 (USF1) regulates the expression of many genes involved
in lipid and glucose metabolism, among them genes regulating lipolysis. USF1 specifically regulates
the expression of the hormone- sensitive lipase gene (HSL) in adipocytes and the hepatic ... Cited by 15 - Related articles - BL Direct - All 4 versions
- ►diabetesjournals.org E Zeggini, CM Damcott, RL Hanson, MA Karim, NW … - Diabetes, 2006 - Am Diabetes Assoc The gene encoding the transcription factor upstream stimulatory factor (USF)1 influences susceptibility
to familial combined hyperlipidemia (FCHL) and triglyceride levels. Phenotypic overlap between
FCHL and type 2 diabetes makes USF1 a compelling positional candidate for the widely ... Cited by 17 - Related articles - BL Direct - All 7 versions
SK Das, SC Elbein - Current Diabetes Reports, 2007 - Springer The unbiased approach of genome-wide linkage analysis has shown evidence for linkage of
type 2 diabetes mel- litus to the chromosome 1q21-25 region in at least eight independent
studies. More than 26 candidate genes have already been evaluated, but to date none ... Cited by 14 - Related articles - BL Direct - All 2 versions
- ►jlr.org GM van der Vleuten, A Isaacs, A Hijmans, CM van … - The Journal of Lipid …, 2007 - ASBMB Recently, the upstream stimulatory factor 1 gene (USF1) was proposed as a candidate gene
for familial combined hyperlipidemia (FCH). In this study, we examined the previously identified
risk haplotype of USF1 with respect to FCH and its related phenotypes in 36 Dutch FCH ... Cited by 12 - Related articles - All 7 versions
MM Van Greevenbroek, VM Vermeulen, EJ … - Diabetic …, 2007 - interscience.wiley.com Aims Thioredoxin interacting protein (TXNIP) is an attractive candidate gene for diabetes or diabetic
dyslipidaemia, since TXNIP is the strongest glucose-responsive gene in pancreatic B-cells, TXNIP
deficiency in a mouse model is associated with hyperlipidaemia and TXNIP is located in ... Cited by 5 - Related articles - BL Direct - All 5 versions
- ►uu.se [PDF] K Auro, K Kristiansson, B Zethelius, C Berne, L Lannfelt … - Diabetologia, 2008 - Springer Page 1. ARTICLE USF1 gene variants contribute to metabolic traits in men in a longitudinal
32-year follow-up study K. Auro & K. Kristiansson & B. Zethelius & C. Berne & L. Lannfelt &
M.-R. Taskinen & M. Jauhiainen & M. Perola & L. Peltonen & A.-C. Syvänen ... Cited by 5 - Related articles - BL Direct - All 4 versions
- ►ahajournals.org A Nohara, M Kawashiri, T Claudel, M Mizuno, … - … , and vascular biology, 2007 - Am Heart Assoc Methods and Results— We screened all the coding regions of the PPAR , PPAR 2, PPAR ,
FXR, LXR , and RXR genes in 180 hyperlipidemic patients including 60 FCHL probands. Clinical
characteristics of the identified variants were evaluated in other 175 patients suspected of ... Cited by 4 - Related articles - All 7 versions
AS Wierzbicki, CA Graham, IS Young, DP … - Current Vascular …, 2008 - ingentaconnect.com Abstract: Familial combined hyperlipidaemia (FCH) was identified in early genetic studies of
populations as a dominant condition associated with mixed hyperlipidaemia and early onset
coronary heart disease. Later studies extended the phe- notype and noted that this ... Cited by 4 - Related articles - BL Direct - All 2 versions
