- ►diabetesjournals.org W Sun, PJ Oates, JB Coutcher, C … - Diabetes, 2006 - Am Diabetes Assoc Previously studied inhibitors of aldose reductase were largely from two chemical
classes, spirosuccinamide/hydantoins and carboxylic acids. Each class has its
own drawbacks regarding selectivity, in vivo potency, and human safety; as ... Cited by 38 - Related articles - BL Direct - All 7 versions
- ►shouxi.net E Ho, KSL Lam, YS Chen, JCW Yip, M … - Diabetes, 2006 - Am Diabetes Assoc The exaggerated flux through polyol pathway during diabetes is thought to be a
major cause of lesions in the peripheral nerves. Here, we used aldose reductase
(AR)-deficient (AR −/− ) and AR inhibitor (ARI)-treated mice to further ... Cited by 30 - Related articles - BL Direct - All 7 versions
- ►nih.gov IG Obrosova, VR Drel, AK Kumagai, C Szabo, … - Diabetologia, 2006 - Springer Abstract Aims/hypothesis Recently, various transgenic and knock- out mouse
models have become available for studying the pathogenesis of diabetic
retinopathy. At the same time, diabetes-induced retinal changes in the ... Cited by 17 - Related articles - BL Direct - All 5 versions
IG Obrosova, W Xu, VV Lyzogubov, O Ilnytska, … - Free Radical Biology and Medicine, 2008 - Elsevier Evidence that poly(ADP-ribose) polymerase (PARP) activation plays an important
role in diabetic complications is emerging. This study evaluated the role of
PARP in rat and mouse models of advanced diabetic neuropathy. The orally ... Cited by 15 - Related articles - All 3 versions
EL Fletcher, JA Phipps, MM Ward, T … - Current pharmaceutical design, 2007 - ingentaconnect.com Abstract: Diabetes is known to cause significant alterations in the retinal
vasculature. Indeed, diabetic retinopathy is the leading cause of blindness in
those of working age. Considerable evidence is emerging that indicates that ... Cited by 15 - Related articles - BL Direct - All 3 versions
VR Drel, P Pacher, I Vareniuk, I Pavlov, O … - European journal of pharmacology, 2007 - pubmedcentral.nih.gov Whereas an important role of free radicals and oxidants in peripheral diabetic
neuropathy is well established, the contribution of nitrosative stress and, in
particular, of the highly reactive oxidant peroxynitrite, has not been ... Cited by 13 - Related articles - All 6 versions
P Canning, JV Glenn, DK Hsu, FT Liu, TA … - Exp Diabetes Res, 2007 - hindawi.com Breakdown of the inner blood-retinal barrier (iBRB) occurs early in diabetes and
is central to the development of sight-threatening diabetic macular edema (DME)
as retinopathy progresses. In the current study, we examined how advanced ... Cited by 11 - Related articles - View as HTML - All 15 versions
ACY Lo, AKH Cheung, VKL Hung, CM Yeung, … - Journal of Cerebral Blood Flow & Metabolism, 2007 - nature.com Previously, we reported that transgenic mice overexpressing endothelin-1 in
astrocytes showed more severe neurological deficits and increased infarct after
transient focal ischemia. In those studies, we also observed increased ... Cited by 11 - Related articles - BL Direct - All 3 versions
M Lorenzi - Exp Diabetes Res, 2007 - hindawi.com The polyol pathway is a two-step metabolic pathway in which glucose is reduced
to sorbitol, which is then converted to fructose. It is one of the most
attractive candidate mechanisms to explain, at least in part, the cellular ... Cited by 9 - Related articles - View as HTML - All 15 versions
Q Huang, N Sheibani - American Journal of Physiology- Cell Physiology, 2008 - Am Physiological Soc Hyperglycemia impacts retinal vascular function and promotes the development and
progression of diabetic retinopathy, which ultimately results in growth of new
blood vessels and loss of vision. How high glucose affects retinal ... Cited by 8 - Related articles - All 3 versions
