- ►ahajournals.org JD Brown, J Plutzky - Circulation, 2007 - Am Heart Assoc Peroxisome proliferator–activated receptors (PPARs) are ligand-activated transcription factors
involved in the transcriptional regulation of key metabolic pathways such as lipid
metabolism, adipogenesis, and insulin sensitivity. More recent work implicates all 3 PPAR ... Cited by 105 - Related articles - All 8 versions
G Targher, G Arcaro - Atherosclerosis, 2007 - Elsevier Non-alcoholic fatty liver disease (NAFLD) is present in up to one-third of the general population
and in the majority of patients with cardio-metabolic risk factors such as abdominal obesity, type
2 diabetes and other components of the metabolic syndrome (MetS). Currently, the ... Cited by 89 - Related articles - All 18 versions
- ►ahajournals.org A Kotronen, H Yki-Jarvinen - Arteriosclerosis, Thrombosis, and …, 2008 - Am Heart Assoc Although the epidemic of obesity has been accompanied by an increase in the prevalence of
the metabolic syndrome, not all obese develop the syndrome and even lean individuals can
be insulin resistant. Both lean and obese insulin resistant individuals have an excess of ... Cited by 82 - Related articles - All 6 versions
G Targher, L Bertolini, R Padovani, S Rodella, G … - Diabetes Care, 2006 - Am Diabetes Assoc RESULTS—NAFLD patients had a markedly greater carotid IMT (1.14 ± 0.20 vs. 0.82 ± 0.12
mm; P < 0.001) than control subjects. The metabolic syndrome (according to Adult Treatment
Panel III criteria) and its individual components were more frequent in those with NAFLD ... Cited by 69 - Related articles - BL Direct - All 5 versions
RK Schindhelm, M Diamant, JM Dekker, ME … - Diabetes/Metabolism … - interscience.wiley.com For a long time, hepatic steatosis was believed to be a benign condition. Only recently, liver
steatosis, also termed non-alcoholic fatty liver disease (NAFLD), has gained much interest. In
most cases of NAFLD, a condition regarded as the hepatic component of the metabolic ... Cited by 63 - Related articles - BL Direct - All 3 versions
SM Haffner - Obesity, 2006 - nature.com The prevalence of obesity and diabetes has reached pandemic proportions. Obesity, particularly
in association with high waist circumference and high BMI, is an independent risk factor for coronary
heart disease (CHD) and diabetes. Several large studies have shown that marginal (5 lb) ... Cited by 51 - Related articles - All 5 versions
M Kolak, J Westerbacka, VR Velagapudi, D Wågsäter, … - Diabetes, 2007 - Am Diabetes Assoc RESULTS— Expression levels of the macrophage marker CD68, the chemokines monocyte
chemoattractant protein-1 and macrophage inflammatory protein-1α, and plasminogen activator
inhibitor-1 were significantly increased, and those of peroxisome proliferator–activated ... Cited by 44 - Related articles - BL Direct - All 10 versions
M Yoneda, H Mawatari, K Fujita, H Iida, K … - Journal of …, 2007 - Springer Page 1. J Gastroenterol 2007; 42:573–582 DOI 10.1007/s00535-007-2060-x Received:
November 26, 2006 / Accepted: March 27, 2007 Reprint requests to: A. Nakajima
High-sensitivity C-reactive protein is an independent clinical feature of ... Cited by 42 - Related articles - BL Direct - All 3 versions
SY Oh, YK Cho, MS Kang, TW Yoo, JH Park, HJ Kim, DI … - Metabolism, 2006 - Elsevier Nonalcoholic fatty liver disease (NAFLD) has been associated with metabolic disorders, including
central obesity, dyslipidema, hypertension, and hyperglycemia. Metabolic syndrome,
obesity, and insulin resistance are major risk factors in the pathogenesis of NAFLD. The ... Cited by 32 - Related articles - All 14 versions
