- ►physiology.org DB Savage, KF Petersen, GI Shulman - Physiological reviews, 2007 - Am Physiological Soc Although abnormal glucose metabolism defines type 2 diabetes mellitus (T2DM) and accounts
for many of its symptoms and complications, efforts to understand the pathogenesis of T2DM
are increasingly focused on disordered lipid metabolism. Here we review recent human ... Cited by 113 - Related articles - BL Direct - All 5 versions
- ►endojournals.org BL Wajchenberg - Endocrine reviews, 2007 - Endocrine Soc There is a progressive deterioration in ß-cell function and mass in type 2 diabetics. It was found
that islet function was about 50% of normal at the time of diagnosis, and a reduction in ß-cell
mass of about 60% was shown at necropsy. The reduction of ß-cell mass is attributable to ... Cited by 105 - Related articles - BL Direct - All 7 versions
- ►jlr.org C Koutsari, MD Jensen - The Journal of Lipid Research, 2006 - ASBMB Adipose tissue lipolysis provides circulating FFAs to meet the body's lipid fuel demands. FFA
release is well regulated in normal-weight individuals; however, in upper-body obesity, excess
lipolysis is commonly seen. This abnormality is considered a cause for at least some of ... Cited by 50 - Related articles - BL Direct - All 6 versions
S Schenk, M Saberi, JM Olefsky - The Journal of Clinical …, 2008 - pubmedcentral.nih.gov Insulin resistance is a major metabolic feature of obesity and is a key factor in the etiology of
a number of diseases, including type 2 diabetes. In this review, we discuss potential mechanisms
by which brief nutrient excess and obesity lead to insulin resistance and propose that ... Cited by 47 - Related articles - All 12 versions
JJ Senn - Journal of Biological Chemistry, 2006 - ASBMB Fatty acids can activate proinflammatory pathways leading to the development of insulin
resistance, but the mechanism is undiscovered. Toll like receptor 2 (TLR2) recognizes lipids,
activates proinflammatory pathways, and is genetically associated with inflammatory ... Cited by 41 - Related articles - BL Direct - All 8 versions
- ►physiology.org AK Dhalla, MY Wong, PJ Voshol, L … - American Journal of …, 2007 - Am Physiological Soc There is substantial evidence in the literature that elevated plasma free fatty acids (FFA) play
a role in the pathogenesis of type 2 diabetes. CVT-3619 is a selective partial A 1 adenosine receptor
agonist that inhibits lipolysis and lowers circulating FFA. The present study was ... Cited by 17 - Related articles - BL Direct - All 6 versions
- ►physicaltherapyjournal.com LP Turcotte, JS Fisher - Physical Therapy, 2008 - physicaltherapyjournal.com The purpose of this review is to provide information about the role of exercise in the prevention
of skeletal muscle insulin resistance, that is, the inability of insulin to properly cause glucose
uptake into skeletal muscle. Insulin resistance is associated with high levels of stored ... Cited by 11 - Related articles - All 31 versions
- ►endocrinology-journals.org RM Luque, MD Gahete, RJ Valentine, RD … - Journal of molecular …, 2006 - Soc Endocrinology In humans, circulating GH levels are increased in catabolic states and suppressed in
obesity. In both extremes, normalization of the metabolic environment normalizes GH
release, leading to the conclusion that changes in metabolic hormones and/or ... Cited by 11 - Related articles - BL Direct - All 4 versions
M Bajaj, R Medina-Navarro, S Suraamornkul, C Meyer, … - Diabetes, 2007 - Am Diabetes Assoc Lipid oversupply plays a role in developing insulin resistance in skeletal muscle, decreasing
expression of nuclear-encoded mitochondrial genes, and increasing extracellular matrix
remodeling. To determine if a decrease in plasma lipid content reverses these ... Cited by 10 - Related articles - BL Direct - All 4 versions
- ►fass.org JAA Pires, JB Pescara, RR Grummer - Journal of Dairy Science, 2007 - Am Dairy Sci Assoc The objective was to investigate the relationship between elevated plasma nonesterified fatty
acid (NEFA) concentration and insulin resistance in Holstein cows. Six nonlactating,
nongestating, ruminally cannulated Holstein cows were blocked by body condition score ... Cited by 9 - Related articles - BL Direct - All 4 versions
