- ►endojournals.org J Gromada, I Franklin, CB Wollheim - Endocrine reviews, 2007 - Endocrine Soc Glucagon, a hormone secreted from the -cells of the endocrine pancreas, is critical for blood
glucose homeostasis. It is the major counterpart to insulin and is released during hypoglycemia
to induce hepatic glucose output. The control of glucagon secretion is multifactorial and ... Cited by 61 - Related articles - BL Direct - All 4 versions
AS Slingerland, R Nuboer, M Hadders-Algra, AT … - Diabetologia, 2006 - Springer Abstract Aims/hypothesis Activating mutations in the KCNJ11 gene encoding the Kir6.2 subunit
of the K ATP channels in pancreatic beta cells are a common cause of neonatal diabetes.
One-third of patients also have developmental delay, which probably results from mutated ... Cited by 23 - Related articles - All 5 versions
N Marty, M Dallaporta, B Thorens - Physiology (Bethesda, Md.), 2007 - ncbi.nlm.nih.gov Neuronal circuits in the central nervous system play a critical role in orchestrating the control
of glucose and energy homeostasis. Glucose, beside being a nutrient, is also a signal detected
by several glucose-sensing units that are located at different anatomical sites and ... Cited by 22 - Related articles - BL Direct - All 4 versions
- ►diabetesjournals.org BE Levin, L Kang, NM Sanders, AA Dunn-Meynell - Diabetes, 2006 - Am Diabetes Assoc Glucosensing is a property of specialized neurons in the brain that regulate their membrane
potential and firing rate as a function of ambient glucose levels. These neurons have several
similarities to β- and α-cells in the pancreas, which are also responsive to ambient ... Cited by 17 - Related articles - BL Direct - All 4 versions
- ►diabetesjournals.org O Chan, M Lawson, W Zhu, JL Beverly, RS Sherwin - Diabetes, 2007 - Am Diabetes Assoc OBJECTIVE—To determine whether alterations in counterregulatory responses to hypoglycemia
through the modulation of ATP-sensitive K + channels (K ATP channels) in the ventromedial
hypothalamus (VMH) are mediated by changes in GABAergic inhibitory tone in the VMH, ... Cited by 11 - Related articles - BL Direct - All 5 versions
GJ Morton - The Journal of Physiology, 2007 - Physiological Soc Growing evidence suggests that food intake, energy expenditure and endogenous glucose production
are regulated by hypothalamic areas that respond to a variety of peripheral signals.
Therefore, in response to a reduction in energy stores or circulating nutrients, the brain ... Cited by 10 - Related articles - BL Direct - All 8 versions
JA Gonzalez, F Reimann, D Burdakov - The Journal of Physiology, 2009 - Physiological Soc Some of the neurones controlling sleep, appetite and hormone release act as specialized detectors
of ambient glucose. Their sugar sensing is conventionally thought to involve glucokinase-dependent
metabolism of glucose to ATP, which then alters membrane excitability by modulating ... Cited by 8 - Related articles - All 5 versions
SR Heller - Diabetes, 2008 - Am Diabetes Assoc In this Perspectives article, I examine the evidence that underpins these interventions. It is beyond
the scope of this article to review the data for each potential intervention in detail, but the reader
is directed to the source where appropriate. The focus of this article is treatment of type 1 ... Cited by 7 - Related articles - All 5 versions
- ►physiology.org L Kang, NM Sanders, AA Dunn-Meynell, … - American Journal of …, 2008 - Am Physiological Soc Antecedent insulin-induced hypoglycemia (IIH) reduces adrenomedullary responses (AMR)
to subsequent bouts of hypoglycemia. The ventromedial hypothalamus [VMH: arcuate (ARC)
+ ventromedial nuclei] contains glucosensing neurons, which are thought to be mediators ... Cited by 6 - Related articles - BL Direct - All 3 versions
RS Sherwin - Diabetes, 2008 - Am Diabetes Assoc My story begins 30 years ago. Bill Tamborlane came to me with a portable, battery-powered
pump being used in pediatrics to infuse the iron-chelating drug desferrioxamine continuously
via the subcutaneous route into children with thalassemia major. He hoped to use it to ... Cited by 7 - Related articles - All 5 versions
