MG Netea, LAB Joosten, E Lewis, DR Jensen, PJ … - Nature - 140.116.93.232 Here we report the presence of hyperphagia, obesity and insulin resistance in knockout mice
deficient in IL-18 or IL-18 receptor, and in mice transgenic for expression of IL-18 binding
protein. Obesity of Il18Ā/Ā mice resulted from accumulation of fat tissue based on ... Cited by 61 - Related articles - View as HTML - BL Direct - All 14 versions
- ►nih.gov A Pocai, TKT Lam, S Obici, R Gutierrez- … - Journal of Clinical …, 2006 - Am Soc Clin Investig Short-term overfeeding blunts the central effects of fatty acids on food intake and glucose
production. This acquired defect in nutrient sensing could contribute to the rapid onset of hyperphagia
and insulin resistance in this model. Here we examined whether central inhibition of lipid ... Cited by 52 - Related articles - BL Direct - All 12 versions
- ►endojournals.org RS Ahima, MA Lazar - Molecular Endocrinology, 2008 - Endocrine Soc Adipokines are secreted by adipose tissue and control various physiological systems. Low leptin
levels during fasting stimulate feeding, reduce energy expenditure, and modulate neuroendocrine
and immune function to conserve energy stores. On the other hand, rising leptin levels in ... Cited by 40 - Related articles - BL Direct - All 8 versions
- ►endojournals.org E Prodi, S Obici - Endocrinology, 2006 - Endocrine Soc Recent evidence highlights the important role of the brain in the control of glucose
homeostasis. Hypothalamic centers sense the availability of peripheral nutrients via redundant
and overlapping nutrient-induced peripheral signals such as leptin and insulin and via ... Cited by 32 - Related articles - BL Direct - All 4 versions
C Buettner, A Pocai, ED Muse, AM Etgen, MG Myers, L … - Cell metabolism, 2006 - Elsevier Leptin has pleiotropic effects on glucose homeostasis and feeding behavior. Here, we validate
the use of a cell-permeable phosphopeptide that blocks STAT3 activation in vivo. The combination
of this biochemical approach with stereotaxic surgical techniques allowed us to pinpoint ... Cited by 33 - Related articles - All 11 versions
- ►diabetesjournals.org RS Ahima, Y Qi, NS Singhal, MB Jackson, PE Scherer - Diabetes, 2006 - Am Diabetes Assoc Adipose tissue secretes factors that control various physiological systems. The fall in leptin during
fasting mediates hyperphagia and suppresses thermogenesis, thyroid and reproductive
hormones, and immune system. On the other hand, rising leptin levels in the fed state ... Cited by 30 - Related articles - BL Direct - All 5 versions
- ►nih.gov D Ren, Y Zhou, D Morris, M Li, Z Li, L … - Journal of Clinical …, 2007 - Am Soc Clin Investig SH2B1 (previously named SH2-B), a cytoplasmic adaptor protein, binds via its Src homology
2 (SH2) domain to a variety of protein tyrosine kinases, including JAK2 and the insulin
receptor. SH2B1-deficient mice are obese and diabetic. Here we demonstrated that ... Cited by 19 - Related articles - BL Direct - All 8 versions
- ►endojournals.org MJ Vazquez, CR Gonzalez, L Varela, R Lage, S Tovar, … - Endocrinology, 2008 - Endocrine Soc Evidence suggests that the adipocyte-derived hormone resistin (RSTN) directly regulates both
feeding and peripheral metabolism through, so far, undefined hypothalamic-mediated
mechanisms. Here, we demonstrate that the anorectic effect of RSTN is associated with ... Cited by 12 - Related articles - All 4 versions
- ►endojournals.org K Guo, JE McMinn, T Ludwig, YH Yu, G Yang, L Chen, … - Endocrinology, 2007 - Endocrine Soc Although central leptin signaling appears to play a major role in the regulation of food intake
and energy metabolism, the physiological role of peripheral leptin signaling and its relative contribution
to whole-body energy metabolism remain unclear. To address this question, we created a ... Cited by 12 - Related articles - BL Direct - All 4 versions
- ►cjb.net D Cota, EK Matter, SC Woods, RJ Seeley - Journal of Neuroscience, 2008 - neuro.cjb.net The mammalian target of rapamycin (mTOR) kinase is a key regulator of several cellular
functions, including cell growth and differentiation. Because hypothalamic mTOR complex 1
(mTORC1) signaling has been implicated as a target of leptin in the regulation of energy ... Cited by 11 - Related articles - All 6 versions
