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Scholar Results 1 - 10 of 10 citing Dolz: Restitution of defective glucose-stimulated insulin secretion in diabetic GK rat by.... (0.11 sec) 

The Free Fatty Acid Receptor GPR40 Generates Excitement in Pancreatic {beta}-Cells


J Gromada - Endocrinology, 2006 - Endocrine Soc
Free fatty acids (FFAs) provide an important energy source and also act as
signaling molecules. Accumulating evidence suggests that FFAs exert a variety of
physiological responses via an emerging family of G protein-coupled ...
Cited by 16 - Related articles - BL Direct - All 4 versions

Soybean oil treatment impairs glucose-stimulated insulin secretion and changes fatty acid …

- uc.pt [PDF] 
E Nunes, F Peixoto, T Louro, CM Sena, MS … - Acta Diabetologica, 2007 - Springer
Abstract We investigated the effect of sub-chronic soy- bean oil (SO) treatment
on the insulin secretion and fatty acid composition of islets of Langerhans
obtained from Goto-Kakizaki (GK), a model of type 2 diabetes, and nor- mal ...
Cited by 7 - Related articles - BL Direct - All 4 versions

Autonomic involvement in the permanent metabolic programming of hyperinsulinemia in the …

- physiology.org
P Mitrani, M Srinivasan, C Dodds, MS Patel - American Journal of Physiology- Endocrinology And …, 2007 - Am Physiological Soc
Exposure to a high-carbohydrate (HC) milk formula during the suckling period
results in permanent metabolic programming of hyperinsulinemia in HC rats.
Previous studies have shown that hyperinsulinemia in HC rats involves a ...
Cited by 6 - Related articles - BL Direct - All 6 versions

The GK rat beta-cell: A prototype for the diseased human beta-cell in type 2 diabetes?

- numesi.com [PDF] 
B Portha, G Lacraz, M Kergoat, F Homo- … - Molecular and Cellular Endocrinology, 2009 - Elsevier
Increasing evidence indicates that decreased functional beta-cell mass is the
hallmark of type 2 diabetes (T2D) mellitus. Nowadays, the debate focuses on the
possible mechanisms responsible for abnormal islet microenvironment, ...
Cited by 6 - Related articles - All 3 versions

Islet gene expression and function in type 2 diabetes; studies in the Goto-Kakizaki rat and …


CG Ostenson, S Efendic - Diabetes Obes Metab - interscience.wiley.com
Defective β-cell function with resulting impairment of glucose-stimulated
insulin release is a critical factor in the pathogenesis of type 2 diabetes.
Accumulated studies in pancreatic islets of the spontaneously diabetic Goto- ...
Cited by 3 - Related articles - All 2 versions

Augmented β cell loss and mitochondrial abnormalities in sucrose-fed GK rats


H Mizukami, R Wada, M Koyama, T Takeo, S … - Virchows Archiv, 2008 - Springer
Abstract Progressive decline of islet β cell mass is a hallmark of type 2
diabetes, where nutritional insults are invoked in the pathologic process. Its
detailed mechanisms are, however, incompletely understood. We explored the ...
Cited by 1 - Related articles - BL Direct - All 4 versions

Diabetic β-Cells Can Achieve Self-Protection against Oxidative Stress through an Adaptive …


G Lacraz, F Figeac, J Movassat, N Kassis, J …, 2009 - pubmedcentral.nih.gov
Localization of OS markers was performed on whole pancreases. Using islets
isolated from 7-day-old or 2.5-month-old male GK/Par and Wistar control rats, 1)
gene expression was analyzed by qRT-PCR; 2) insulin secretion rate was ...
Cited by 1 - Related articles - All 5 versions

Effects of Oral Administration of Moringa oleifera Lam on Glucose Tolerance in Goto- …


M Ndong, M Uehara, S Katsumata, K Suzuki - Journal of Clinical Biochemistry and Nutrition, 2007 - pubmedcentral.nih.gov
Medicinal plants constitute an important source of potential therapeutic agents
for diabetes. In the present study, we investigated the effects of Moringa
oleifera (MO) Lam, Moringacea, on glucose tolerance in Wistar rats and Goto- ...
Related articles - BL Direct - All 4 versions

Defective functional-cell mass and Type 2 diabetes in the GotoKakizaki rat model


B Portha, G Lacraz, M Dolz, F Homo-Delarche … - Expert Review of Endocrinology and Metabolism, 2007 - ingentaconnect.com
† Author for correspondence Laboratoire de Physiopathologie de la Nutrition,
CNRS UMR 7059, Université Paris-Diderot, 2 Place Jussieu, 75251 Paris Cedex 05,
France Tel.: +33 144 275 011 Fax: +33 144 277 891 portha@univ-paris-diderot.fr
Related articles - BL Direct - All 3 versions

5 The Goto-Kakizaki Rat


CG Ostenson - Animal models of diabetes: frontiers in research, 2007 - books.google.com
5 The Goto-Kakizaki Rat Claes-Goran Ostenson CONTENTS Introduction 119 Origin
and Breeding of the GK Rat 120 GK Rat Colonies 120 Maintenance and Breeding of
GK Rat 120 Glucose Tolerance and Plasma Insulin Levels 121 Genetic ...
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