- ►diabetesjournals.org M Cnop, N Welsh, JC Jonas, A Jörns, S Lenzen … - Diabetes, 2005 - Am Diabetes Assoc Type 1 and type 2 diabetes are characterized by progressive β-cell failure.
Apoptosis is probably the main form of β-cell death in both forms of the
disease. It has been suggested that the mechanisms leading to nutrient- and ... Cited by 169 - Related articles - BL Direct - All 10 versions
- ►jhsph.edu [PDF] CM Larsen, M Faulenbach, A Vaag, A Volund, … - The New England journal of medicine, 2007 - nejm.highwire.org Methods In this double-blind, parallel-group trial involving 70 patients with
type 2 diabetes, we randomly assigned 34 patients to receive 100 mg of anakinra
(a recombinant human interleukin-1–receptor antagonist) subcutaneously ... Cited by 137 - Related articles - BL Direct - All 12 versions
- ►endojournals.org DL Eizirik, AK Cardozo, M Cnop - Endocrine Reviews, 2008 - Endocrine Soc Accumulating evidence suggests that endoplasmic reticulum (ER) stress plays a
role in the pathogenesis of diabetes, contributing to pancreatic β-cell loss
and insulin resistance. Components of the unfolded protein response (UPR) ... Cited by 89 - Related articles - BL Direct - All 5 versions
- ►biologists.org DA Cunha, P Hekerman, L Ladriere, A Bazarra- … - Journal of cell science, 2008 - jcs.biologists.org Free fatty acids (FFA) cause apoptosis of pancreatic β-cells and might
contribute to β-cell loss in type 2 diabetes via the induction of endoplasmic
reticulum (ER) stress. We studied here the molecular mechanisms implicated ... Cited by 23 - Related articles - All 5 versions
- ►endojournals.org MY Donath, J Storling, LA Berchtold, N … - Endocrine Reviews, 2008 - Endocrine Soc The tale of cytokines and the β-cell is a long story, starting with in vitro
discovery in 1984, evolving via descriptive and phenomenological studies to
detailed mapping of the signalling pathways, gene- and protein expression ... Cited by 20 - Related articles - BL Direct - All 6 versions
MY Donath, DM Schumann, M Faulenbach, H … - Diabetes Care, 2008 - Am Diabetes Assoc Inflammation is defined as the local response to tissue injury. It is
characterized by immune cell invasion and local release of cytokines and
chemokines and is sometimes accompanied by functional or structural damage ... Cited by 20 - Related articles - BL Direct - All 4 versions
- ►endojournals.org EC Kaizer, CL Glaser, D Chaussabel, J … - Journal of Clinical Endocrinology & Metabolism, 2007 - Endocrine Soc Results: Microarray analysis identified 282 genes differing in expression
between newly diagnosed T1D patients and controls at a false discovery rate of
0.05. Changes in expression of IL1B, early growth response gene 3, and ... Cited by 18 - Related articles - BL Direct - All 3 versions
R Lupi, S Del Prato - Diabetes and Metabolism, 2008 - Elsevier Type 2 diabetes, the most common form of diabetes in humans, is characterized by
impaired insulin secretion paralleled by a progressive decline in β-cell
function and chronic insulin resistance. Several authors have showed that ... Cited by 19 - Related articles - All 2 versions
- ►endojournals.org NS Sauter, FT Schulthess, R Galasso, LW … - Endocrinology, 2008 - Endocrine Soc Subclinical inflammation is a recently discovered phenomenon in type 2 diabetes.
Elevated cytokines impair β-cell function and survival. A recent clinical trial
shows that blocking IL-1β signaling by IL-1 receptor antagonist (IL-1Ra) ... Cited by 18 - Related articles - BL Direct - All 4 versions
E Ruotsalainen, U Salmenniemi, I Vauhkonen, … - Diabetes Care, 2006 - Am Diabetes Assoc RESULTS—Levels of C-reactive protein and inflammatory cytokines were elevated
in nondiabetic offspring of type 2 diabetic subjects. Interleukin (IL)-1β was
increased in the NGT group and decreased in the IGT group. In contrast, ... Cited by 17 - Related articles - BL Direct - All 5 versions
