- ►nih.gov MA Herman, BB Kahn - Journal of Clinical Investigation, 2006 - Am Soc Clin Investig The prevalence of obesity and type 2 diabetes continues to increase at alarming rates (1). Type
2 diabetes is a prototypic complex, polygenic disease with a strong heritable component, which
is also heavily influenced by environmental factors — especially diet and physical activity. ... Cited by 58 - Related articles - BL Direct - All 9 versions
- ►diabetesjournals.org BE Levin, L Kang, NM Sanders, AA Dunn-Meynell - Diabetes, 2006 - Am Diabetes Assoc Glucosensing is a property of specialized neurons in the brain that regulate their membrane
potential and firing rate as a function of ambient glucose levels. These neurons have several
similarities to β- and α-cells in the pancreas, which are also responsive to ambient ... Cited by 17 - Related articles - BL Direct - All 4 versions
AV Matveyenko, CM Donovan - Diabetes, 2006 - Am Diabetes Assoc The current study sought to ascertain whether portal vein glucose sensing is mediated by a metabolic
fuel sensor analogous to other metabolic sensors presumed to mediate hypoglycemic detection
(eg, hypothalamic metabosensors). We examined the impact of selectively elevating ... Cited by 10 - Related articles - BL Direct - All 5 versions
M Saberi, MA Bohland, CM Donovan - Diabetes, 2008 - Am Diabetes Assoc RESULTS—Inducing hypoglycemia slowly, at a rate of −0.09 mmol · l −1 · min −1 , resulted in
a 26-fold increase in epinephrine (23.39 ± 0.62 nmol/l) and 12-fold increase in norepinephrine
(11.42 ± 0.92 nmol/l) for controls (P < 0.001). The epinephrine response to hypoglycemia ... Cited by 7 - Related articles - BL Direct - All 4 versions
- ►physiology.org S Fujita, MA Bohland, G Sanchez-Watts, … - American Journal of …, 2007 - Am Physiological Soc To elucidate the type of spinal afferent involved in hypoglycemic detection at the portal vein,
we considered the potential role of capsaicin-sensitive primary sensory neurons.
Specifically, we examined the effect of capsaicin-induced ablation of portal vein afferents ... Cited by 7 - Related articles - BL Direct - All 6 versions
- ►physiology.org AC Ertl, S Mann, A Richardson, VJ Briscoe … - American Journal of …, 2008 - Am Physiological Soc The effects of oral carbohydrate on modulating counterregulatory responses in humans remain
undecided. This study's specific aim was to determine the effects of oral carbohydrate on autonomic
nervous system (ANS) and neuroendocrine responses during hyperinsulinemic ... Cited by 3 - Related articles - All 4 versions
- ►physiology.org AV Matveyenko, MA Bohland, M Saberi, … - American Journal of …, 2007 - Am Physiological Soc Antecedent hypoglycemia leads to impaired counterregulation and hypoglycemic
unawareness. To ascertain whether antecedent portal vein hypoglycemia impairs portal vein
glucose sensing, thereby inducing counterregulatory failure, we compared the effects of ... Cited by 2 - Related articles - BL Direct - All 3 versions
CA DiCostanzo, DP Dardevet, PE Williams, M Courtney … - Metabolism, 2007 - Elsevier We examined the role of vagus nerves in the transmission of the portal glucose signal in conscious
dogs. At time 0, somatostatin infusion was started along with intraportal insulin and glucagon
at 4-fold basal and basal rates, respectively. Glucose was infused via a peripheral vein to ... Cited by 1 - Related articles - All 7 versions
AD Cherrington - Diabetes, 2008 - Am Diabetes Assoc One of the most significant limits in our ability to tightly control blood glucose in patients with
diabetes is the occurrence of hypoglycemia. It is now clear that when blood glucose drops in
a normal individual, there is a rapid and well-coordinated endocrine response (1). ... Cited by 1 - Related articles - BL Direct - All 3 versions
V Sejian, S Sanyal, PK DAS, PR GHOSH, B … - Turk. J. Vet. Anim. …, 2008 - journals.tubitak.gov.tr The adrenals are bilaterally symmetrical glands located anterior to the kidneys. Each gland has
2 anatomically and physiologically different parts, which are identified as the cortex and
medulla. The cortex is derived from the mesoderm and produces cortisol, corticosterone, ... Related articles - View as HTML - All 3 versions
