- ►nih.gov T Kadowaki, T Yamauchi, N Kubota, K … - Journal of Clinical …, 2006 - Am Soc Clin Investig Adiponectin is an adipokine that is specifically and abundantly expressed in adipose tissue and
directly sensitizes the body to insulin. Hypoadiponectinemia, caused by interactions of genetic
factors such as SNPs in the Adiponectin gene and environmental factors causing obesity, ... Cited by 411 - Related articles - BL Direct - All 9 versions
T Yamauchi, Y Nio, T Maki, M Kobayashi, T … - Nature - xn-- … Page 1. 332 VOLUME 13 | NUMBER 3 | MARCH 2007 NATURE MEDICINE Targeted
disruption of AdipoR1 and AdipoR2 causes abrogation of adiponectin binding and
metabolic actions Toshimasa Yamauchi 1–3,7 ,Yasunori ... Cited by 170 - Related articles - View as HTML - BL Direct - All 10 versions
- ►endojournals.org AM Sharma, B Staels - Journal of Clinical Endocrinology & Metabolism, 2007 - Endocrine Soc Conclusions: PPAR is highly expressed in adipose tissue, where its activation with thiazolidinediones
alters fat topography and adipocyte phenotype and up-regulates genes involved in fatty acid
metabolism and triglyceride storage. Furthermore, PPAR activation is associated with ... Cited by 99 - Related articles - BL Direct - All 3 versions
- ►cell.com T Inagaki, P Dutchak, G Zhao, X Ding, L Gautron, V … - Cell metabolism, 2007 - Elsevier Peroxisome proliferator-activated receptor α (PPARα) regulates the utilization of fat as an energy
source during starvation and is the molecular target for the fibrate dyslipidemia drugs. Here, we
identify the endocrine hormone fibroblast growth factor 21 (FGF21) as a mediator of the ... Cited by 97 - Related articles - All 10 versions
MJ Yoon, GY Lee, JJ Chung, YH Ahn, SH Hong, JB … - Diabetes, 2006 - Am Diabetes Assoc Adiponectin has recently received a great deal of attention due to its beneficial effects on insulin
resistance and metabolic disorders. One of the mechanisms through which adiponectin exerts
such effects involves an increase in fatty acid oxidation in muscle and liver. In the present ... Cited by 84 - Related articles - BL Direct - All 6 versions
C Fiévet, JC Fruchart, B Staels - Current Opinion in Pharmacology, 2006 - Elsevier The discovery of the crucial role of peroxisome proliferator-activated receptors (PPARs) as regulators
of lipid and glucose metabolism has raised interest in the development of synthetic ligands as
potential tools for therapeutic intervention in type 2 diabetes and the metabolic syndrome. ... Cited by 56 - Related articles - All 2 versions
- ►endojournals.org PD Anderson, NN Mehta, ML Wolfe, CC Hinkle, … - Journal of Clinical …, 2007 - Endocrine Soc Context: Chronic inflammation converges in type 2 diabetes and atherosclerosis. Modulation
of adipokine signaling by innate immunity in humans is of considerable interest given the role
of adipokines in insulin resistance and atherosclerosis. ... Objective: The aim of the study ... Cited by 46 - Related articles - BL Direct - All 4 versions
B Pourcet, JC Fruchart, B Staels, C … - Expert Opin. Emerging …, 2006 - informahealthcare.com More than 70% of patients with Type 2 diabetes mellitus (T2DM) die because of cardiovascular
diseases. Current therapeutic strategies are based on separate treatment of insulin resistance
and dyslipidaemia. Development of drugs with multimodal activities should improve ... Cited by 40 - Related articles - BL Direct - All 6 versions
- ►ahajournals.org A Hiuge, A Tenenbaum, N Maeda, M … - … , and vascular biology, 2007 - Am Heart Assoc From Department of Metabolic Medicine (AH, NM, MK, TH, KF, HN, SK, IS, TF), Graduate School
of Medicine, Osaka University, Osaka, Japan; Cardiac Rehabilitation Institute (AT, EZF, YA,
MM), The Israel Society for the Prevention of Hearth Attacks (ISPHA) (MB, DT, SB), the ... Cited by 39 - Related articles - All 8 versions
M Guerre-Millo - Diabetes and Metabolism, 2008 - Elsevier The discoveries of leptin and adiponectin were breakthroughs in the field of metabolic
diseases. Adipose cells produce both proteins and release them into the circulation. Leptin acts
as a fundamental signal for the brain to modulate food intake as a function of energy ... Cited by 36 - Related articles - BL Direct - All 2 versions
