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Scholar Results 1 - 10 of about 19 citing Morton: A polygenic model of the metabolic syndrome with reduced circulating and intra-adipose.... (0.09 sec) 

Tissue production of cortisol by 11beta-hydroxysteroid dehydrogenase type 1 and …


BR Walker, R Andrew - Ann NY Acad Sci, 2006 - interscience.wiley.com
Abstract: Activation of intracellular glucocorticoid receptors is determined not only by the plasma
concentrations of cortisol, under the influence of the hypothalamic-pituitary-adrenal (HPA)
axis, but also by 11HSD enzymes within the target cell which interconvert cortisol with its ...
Cited by 32 - Related articles - BL Direct - All 4 versions

Readjusting the Glucocorticoid Balance: An Opportunity for Modulators of 11- …


AG Atanasov, A Odermatt - … &# 38; Immune Disorders-Drug Targets …, 2007 - ingentaconnect.com
Abstract: Glucocorticoids play a pivotal role in the regulation of most essential physiological
processes, including energy metabolism, maintenance of electrolyte balance and blood
pressure, immune-modulation and stress responses, cell prolif- eration and ...
Cited by 17 - Related articles - BL Direct - All 2 versions

Adrenocortical dysregulation as a major player in insulin resistance and onset of …

- physiology.org
C Roberge, AC Carpentier, MF Langlois, … - American Journal of …, 2007 - Am Physiological Soc
The aim of this review is to explore the dysregulation of adrenocortical secretions as a major
contributor in the development of obesity and insulin resistance. Disturbance of adipose tissue
physiology is one of the primary events in the development of pathologies associated with ...
Cited by 15 - Related articles - BL Direct - All 5 versions

Mechanisms of disease: regulation of glucocorticoid and receptor levels—impact …


SF Witchel, DB DeFranco - Nature Reviews Endocrinology, 2006 - nature.com
Glucocorticoids exert their effects in target tissues predominantly through their interaction with
the glucocorticoid receptor, a member of the nuclear receptor superfamily of transcription
factors. Over the years many studies have linked hormone responsiveness, both in vitro ...
Cited by 12 - Related articles - BL Direct - All 3 versions

11 p-Hydroxysteroid Dehydrogenase Type 1 and Obesity


NM Morton, JR Seckl - Obesity and metabolism, 2008 - books.google.com
Korbonits M (ed): Obesity and Metabolism. Front Horm Res. Basel, Karger, 2008, vol 36, pp
146-164 11 p-Hydroxysteroid Dehydrogenase Type 1 and Obesity Nicholas M. Morton• Jonathan
R. Seckl Endocrinology Unit, Centre for Cardiovascular Sciences, Queens Medical ...
Cited by 9 - Related articles - BL Direct - All 5 versions

11-Beta-hydroxysteroid dehydrogenase type 1 (11β-HSD1) inhibitors in Type 2 …


KA Hughes, SP Webster, BR … - Expert Opin. Investig. …, 2008 - informahealthcare.com
Background: Glucocorticoids such as cortisol are important regulators of fuel metabolism during
starvation and stress. Chronic glucocorticoid excess induces obesity with multiple features of
the metabolic syndrome. Objective: In this article, we review the importance of ...
Cited by 7 - Related articles - BL Direct - All 7 versions

Changes in adiponectin and inflammatory genes in response to hormonal …

- endojournals.org
H Zhang, X Chen, J Aravindakshan, MR Sairam - Endocrinology, 2007 - Endocrine Soc
Early obesity and late onset of insulin resistance associated with hormonal imbalances occur
in FSH receptor-deficient follitropin receptor knockout female mice. This study tests the hypothesis
that chronic high-fat diet aggravates obesogenic changes in a depot-specific manner and ...
Cited by 4 - Related articles - BL Direct - All 3 versions

Glucocorticoid receptor haploinsufficiency causes hypertension and attenuates …

- fasebj.org
Z Michailidou, RN Carter, E Marshall, HG Sutherland, … - The FASEB Journal, 2008 - FASEB
Glucocorticoid hormones are critical to respond and adapt to stress. Genetic variations in the
glucocorticoid receptor (GR) gene alter hypothalamic-pituitary-adrenal (HPA) axis activity and
associate with hypertension and susceptibility to metabolic disease. Here we test the ...
Cited by 3 - Related articles - All 5 versions

Peripheral mechanisms contributing to the glucocorticoid hypersensitivity in …

- endocrinology-journals.org
Z Michailidou, AP Coll, CJ Kenyon, NM … - Journal of …, 2007 - Soc Endocrinology
Proopiomelanocortin (POMC) deficiency causes severe obesity through hyperphagia of hypothalamic
origin. However, low glucocorticoid levels caused by adrenal insufficiency mitigate against insulin
resistance, hyperphagia and fat accretion in Pomc –/– mice. Upon exogenous ...
Cited by 2 - Related articles - BL Direct - All 11 versions

Ascorbic acid oral treatment modifies lipolytic response and behavioural activity but …


DF Garcia-Diaz, J Campion, FI Milagro, L … - Acta …, 2009 - interscience.wiley.com
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Cited by 1 - Related articles - All 3 versions


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