- ►nih.gov V Lefebvre, B Dumitriu, A Penzo-Méndez, Y Han, B … - International Journal of …, 2007 - Elsevier Maintain stemness, commit to a specific lineage, differentiate, proliferate, or die. These are
essential decisions that every cell is constantly challenged to make in multi-cellular organisms to
ensure proper development, adult ... Cited by 46 - Related articles - All 3 versions
FC Lynn, SB Smith, ME Wilson, KY Yang, … - Proceedings of the …, 2007 - National Acad Sciences During pancreas development, both the exocrine and endocrine lineages differentiate from a common
pool of progenitor cells with similarities to mature pancreatic duct cells. A small set of
transcription factors, including ... Cited by 27 - Related articles - BL Direct - All 9 versions
JM Oliver-Krasinski, DA Stoffers - Genes & development, 2008 - genesdev.cshlp.org The major forms of diabetes are characterized by pancreatic islet β-cell dysfunction and decreased
β-cell numbers, raising hope for cell replacement therapy. Although human islet transplantation is
a cell-based therapy under clinical ... Cited by 21 - Related articles - All 4 versions
- ►alphamedpress.org I Serafimidis, I Rakatzi, V Episkopou, M Gouti, A … - Stem Cells, 2008 - AlphaMed Press The delineation of regulatory networks involved in early endocrine pancreas specification will play
a crucial role in directing the differentiation of embryonic stem cells toward the mature phenotype
of β cells for cell therapy of ... Cited by 17 - Related articles - BL Direct - All 6 versions
- ►nih.gov P Dy, A Penzo-Mendez, H Wang, CE Pedraza, … - Nucleic acids …, 2008 - Oxford Univ Press The group C of Sry-related high-mobility group (HMG) box (Sox) transcription factors has three
members in most vertebrates: Sox4, Sox11 and Sox12. Sox4 and Sox11 have key roles in cardiac,
neuronal and other major ... Cited by 10 - Related articles - BL Direct - All 6 versions
- ►biologists.org N Nekrep, J Wang, T Miyatsuka, MS German - Development, 2008 - dev.biologists.org Pancreatic islet cells and neurons share common functions and similar ontogenies, but originate in
different germ layers. To determine whether ectoderm-derived cells contribute instructive signals to
the developing endoderm-derived ... Cited by 8 - Related articles - All 4 versions
- ►nih.gov M Hoser, MR Potzner, J Koch, MR Bosl, M … - Molecular and cellular …, 2008 - Am Soc Microbiol The transcription factors Sox4 and Sox11 are important regulators of diverse developmental processes
including heart, lung, pancreas, spleen, and B-cell development. Here we have studied the role of
the related Sox12 as the third ... Cited by 4 - Related articles - All 8 versions
- ►harvard.edu [PDF] CD Scharer, CD McCabe, M Ali-Seyed, MF Berger, ML … - Cancer research, 2009 - AACR The sex determining region Y-box 4 (SOX4) gene is a developmental transcription factor important for
progenitor cell development and Wnt signaling (1, 2). SOX4 is a 47-kDa protein that is encoded by a
single exon and contains a ... Cited by 5 - Related articles - All 5 versions
- ►diabetesjournals.org M Goldsworthy, A Hugill, H Freeman, E Horner, K … - Diabetes, 2008 - Am Diabetes Assoc RESEARCH DESIGN AND METHODS— Haploinsufficiency of the insulin receptor and associated mild
insulin resistance has been used to sensitize an N-ethyl-N-nitrosourea (ENU) screen to identify
novel mutations resulting in ... Cited by 3 - Related articles - All 6 versions
A Penzo-Méndez, P Dy, B Pallavi, V … - Developmental Genetics - interscience.wiley.com Sox4 belongs to the family of Sry-related HMG box transcription factors, which specify cell fate and
differentiation in many lineages. Sox4 is widely expressed in the embryo and controls such processes
as neuronal tissue, lymphocyte, ... Cited by 3 - Related articles - BL Direct - All 3 versions
