- ►diabetesjournals.org L Zheng, SJ Howell, DA Hatala, K Huang, TS … - Diabetes, 2007 - Am Diabetes Assoc It has been previously reported that aspirin inhibited the development of
diabetic retinopathy in diabetic animals, raising the possibility that
anti-inflammatory drugs may have beneficial effects on diabetic ... Cited by 42 - Related articles - BL Direct - All 12 versions
- ►diabetesjournals.org W Sun, PJ Oates, JB Coutcher, C … - Diabetes, 2006 - Am Diabetes Assoc Previously studied inhibitors of aldose reductase were largely from two chemical
classes, spirosuccinamide/hydantoins and carboxylic acids. Each class has its
own drawbacks regarding selectivity, in vivo potency, and human safety; as ... Cited by 38 - Related articles - BL Direct - All 7 versions
- ►diabetesjournals.org TS Kern, CM Miller, Y Du, L Zheng, S Mohr, … - Diabetes, 2007 - Am Diabetes Assoc Pharmacologic treatment of diabetic retinopathy via eyedrops could have
advantages but has not been successful to date. We explored the effect of
topical Nepafenac, an anti-inflammatory drug known to reach the retina when ... Cited by 35 - Related articles - BL Direct - All 4 versions
TS Kern - Exp Diabetes Res, 2007 - hindawi.com Diabetes causes metabolic and physiologic abnormalities in the retina, and these
changes suggest a role for inflammation in the development of diabetic
retinopathy. These changes include upregulation of iNOS, COX-2, ICAM-1, ... Cited by 34 - Related articles - View as HTML - All 12 versions
EL Fletcher, JA Phipps, MM Ward, T … - Current pharmaceutical design, 2007 - ingentaconnect.com Abstract: Diabetes is known to cause significant alterations in the retinal
vasculature. Indeed, diabetic retinopathy is the leading cause of blindness in
those of working age. Considerable evidence is emerging that indicates that ... Cited by 15 - Related articles - BL Direct - All 3 versions
- ►amjpathol.org Y Behl, P Krothapalli, T Desta, A DiPiazza, S … - American Journal of Pathology, 2008 - ASIP Retinal microvascular cell loss plays a critical role in the pathogenesis of
diabetic retinopathy. To examine this further, type 1 streptozotocin-induced
diabetic rats and type 2 Zucker diabetic fatty rats were treated by ... Cited by 9 - Related articles - BL Direct - All 6 versions
M Lorenzi - Exp Diabetes Res, 2007 - hindawi.com The polyol pathway is a two-step metabolic pathway in which glucose is reduced
to sorbitol, which is then converted to fructose. It is one of the most
attractive candidate mechanisms to explain, at least in part, the cellular ... Cited by 9 - Related articles - View as HTML - All 15 versions
ZA Khan, S Chakrabarti - Exp Diabetes Res, 2007 - hindawi.com Dysfunction and death of microvascular cells and imbalance between the
production and the degradation of extracellular matrix (ECM) proteins are a
characteristic feature of diabetic retinopathy (DR). Glucose-induced ... Cited by 8 - Related articles - View as HTML - All 15 versions
AP Adamis, AJ Berman - Seminars in Immunopathology, 2008 - Springer Abstract There is an accumulating body of evidence that immunological mechanisms
play a prominent role in the pathogenesis of diabetic retinopathy (DR), which is
charac- terized by many features typical of inflammation. The upregulation ... Cited by 7 - Related articles - BL Direct - All 3 versions
V Sibilia, F Pagani, N Lattuada, V De Luca, F … - Pharmacological research, 2007 - Elsevier Ticlopidine does not affect gastric mucosal integrity either after acute (100
and 300 mg kg −1 ) or 1-week (100 mg kg −1 , die) oral administration.
Ticlopidine (30–300 mg kg −1 , os) administered 1 h before EtOH dose- ... Cited by 4 - Related articles - All 4 versions
