- ►endojournals.org HS Freitas, GF Anhe, KFS Melo, MM Okamoto, … - Endocrinology, 2008 - Endocrine Soc Mutations in Na + -glucose transporters (SGLT)-2 and hepatocyte nuclear factor
(HNF)-1 genes have been related to renal glycosuria and maturity-onset diabetes
of the young 3, respectively. However, the expression of these genes have ... Cited by 9 - Related articles - BL Direct - All 2 versions
B Komoroski, N Vachharajani, D Boulton, D … - Clinical Pharmacology & Therapeutics, 2009 - nature.com Dapagliflozin selectively inhibits renal glucose reabsorption by inhibiting
sodium–glucose cotransporter-2 (SGLT2). It was developed as an
insulin-independent treatment approach for type 2 diabetes mellitus (T2DM). ... Cited by 6 - Related articles - All 4 versions
MA Abdul-Ghani, RA DeFronzo - Endocrine Practice, 2008 - AACE The prevalence of type 2 diabetes mellitus (T2DM) has increased progressively to
epidemic proportions dur- ing the past 20 years (1). Patients with T2DM have
increased morbidity and mortality, the majority of which results from ... Cited by 5 - Related articles - All 2 versions
GL Bakris, VA Fonseca, K Sharma, EM Wright - Kidney International, 2009 - nature.com The kidneys play a major role in the regulation of glucose in humans,
reabsorbing 99% of the plasma glucose that filters through the renal glomeruli
tubules. The glucose transporter, SGLT2, which is found primarily in the S1 ... Cited by 4 - Related articles - All 3 versions
- ►mcw.edu [PDF] NM Tabatabai, M Sharma, SS Blumenthal, DH … - Diabetes Research and Clinical Practice, 2009 - Elsevier Diabetes-mediated changes in mRNA expressions of kidney glucose transporters
SGLT1 and SGLT2 were investigated in Zucker rats. SGLTs expressions in
pre-diabetic obese rats were similar to leans. SGLT1 and SGLT2 levels in ... Cited by 1 - Related articles - All 12 versions
O Marsenic - American Journal of Kidney Diseases, 2009 - Elsevier The full significance of the kidney's role in glucose homeostasis is now well
recognized. For example, it is now known that renal gluconeogenesis contributes
substantially to total-body glucose release in the postabsorptive state. ... Cited by 1 - Related articles - All 2 versions
S Nair, JPH Wilding - Journal of Clinical Endocrinology & Metabolism, 2009 - Endocrine Soc Context: Sodium-glucose cotransporter 2 (SGLT2) expressed in the proximal renal
tubules accounts for about 90% of the reabsorption of glucose from tubular
fluid. Genetic defects of SGLT2 result in a benign familial renal ...
MFA Borghese, MP Majowicz - Drugs of the Future, 2009 - journals.prous.com Sodium/glucose cotransporters (SGLTs) belong to the solute carrier family 5
(SLC5), which has more than 200 members in animal and bacterial cells. This gene
family was originally thought to contain only 11 members of the human ... Related articles - All 2 versions
