GS Hotamisligil… - NATURE-LONDON-, 2006 - cms1.daegu.ac.kr The incidence of obesity worldwide has increased drastically during recent decades.
Consequently, obesity and associated disorders now constitute a serious threat to the current
and future health of all popu- lations on Earth. The World Health Organization estimates ... Cited by 587 - Related articles - View as HTML - BL Direct - All 15 versions
- ►nih.gov H Shi, MV Kokoeva, K Inouye, I Tzameli, H … - Journal of Clinical …, 2006 - Am Soc Clin Investig TLR4 is the receptor for LPS and plays a critical role in innate immunity. Stimulation of TLR4
activates proinflammatory pathways and induces cytokine expression in a variety of cell
types. Inflammatory pathways are activated in tissues of obese animals and humans and ... Cited by 320 - Related articles - BL Direct - All 13 versions
- ►ahajournals.org J Kim, M Montagnani, KK Koh, MJ Quon - Circulation, 2006 - Am Heart Assoc Endothelial dysfunction contributes to cardiovascular diseases, including hypertension,
atherosclerosis, and coronary artery disease, which are also characterized by insulin
resistance. Insulin resistance is a hallmark of metabolic disorders, including type 2 ... Cited by 322 - Related articles - All 9 versions
- ►endojournals.org R Muniyappa, M Montagnani, KK Koh, MJ Quon - Endocrine reviews, 2007 - Endocrine Soc Insulin has important vascular actions to stimulate production of nitric oxide from
endothelium. This leads to capillary recruitment, vasodilation, increased blood flow, and subsequent
augmentation of glucose disposal in classical insulin target tissues (e.g., skeletal muscle). ... Cited by 101 - Related articles - BL Direct - All 5 versions
- ►nih.gov VT Samuel, ZX Liu, A Wang, SA Beddow, … - Journal of Clinical …, 2007 - Am Soc Clin Investig Nonalcoholic fatty liver disease is strongly associated with hepatic insulin resistance and type
2 diabetes mellitus, but the molecular signals linking hepatic fat accumulation to hepatic insulin
resistance are unknown. Three days of high-fat feeding in rats results specifically in ... Cited by 64 - Related articles - BL Direct - All 9 versions
EA Roberts - Clinics in liver disease, 2007 - Elsevier Non-alcoholic steatohepatitis (NASH) is an important liver disease in children; it can cause cirrhosis
in children. The disease mechanism involves hepatic insulin resistance with hyperinsulinemia
and changes in certain adipocytokines and inflammatory mediators. The differential ... Cited by 53 - Related articles - BL Direct - All 33 versions
EP Newberry, Y Xie, SM Kennedy, J Luo, NO … - Hepatology, 2006 - interscience.wiley.com Liver fatty acid-binding protein (L-Fabp) regulates murine hepatic fatty acid trafficking in response
to fasting. In this study, we show that L-Fabp -/- mice fed a high-fat Western diet for up to 18 weeks
are less obese and accumulate less hepatic triglyceride than C57BL/6J controls. ... Cited by 49 - Related articles - BL Direct - All 3 versions
RS Rector, JP Thyfault, Y Wei, JA … - World Journal of …, 2008 - pubmedcentral.nih.gov Sedentary lifestyle and poor dietary choices are leading to a weight gain epidemic in westernized
countries, subsequently increasing the risk for developing the metabolic syndrome and nonalcoholic
fatty liver disease (NAFLD). NAFLD is estimated to affect approximate 30% of the general ... Cited by 49 - Related articles - BL Direct - All 10 versions
G Boden, M Zhang - Expert Opin. Investig. Drugs, 2006 - Informa Pharma Science Thiazolidinediones (TZDs) are peroxisomal proliferator-activated receptor (PPAR)-γ
agonists. They increase insulin action through several mechanisms including: stimulation of
the expression of genes that increase fat oxidation and lower plasma free fatty acid levels; ... Cited by 45 - Related articles - BL Direct - All 5 versions
G Boden - Current diabetes reports, 2006 - Springer Plasma free fatty acid (FFA) levels are elevated in obesity. FFA, by causing insulin resistance
in muscle, liver, and endothelial cells, contributes to the development of type 2 diabetes mellitus
(T2DM), hypertension, dyslipidemia, and nonalcoholic fatty liver disease (NAFLD). The ... Cited by 42 - Related articles - BL Direct - All 4 versions
