S Boudina, ED Abel - Circulation, 2007 - Am Heart Assoc The prevalence of diabetes mellitus is growing rapidly. It is estimated that
globally the number of adults affected with diabetes will increase from 135
million in 1995 to 300 million by 2025. 1 Patients with diabetes mellitus ... Cited by 136 - Related articles - All 5 versions
D An, B Rodrigues - American Journal of Physiology- Heart and Circulatory …, 2006 - Am Physiological Soc In patients with diabetes, an increased risk of symptomatic heart failure
usually develops in the presence of hypertension or ischemic heart disease.
However, a predisposition to heart failure might also reflect the effects ... Cited by 66 - Related articles - BL Direct - All 5 versions
- ►diabetesjournals.org S Boudina, S Sena, H Theobald, X Sheng, JJ … - Diabetes, 2007 - Am Diabetes Assoc RESULTS—db/db hearts exhibited reduced cardiac function and increased MVo 2 .
Mitochondrial reactive oxygen species (ROS) generation and lipid and protein
peroxidation products were increased. Mitochondrial proliferation was ... Cited by 41 - Related articles - BL Direct - All 4 versions
- ►physiology.org S Boudina, ED Abel - Physiology, 2006 - Am Physiological Soc Diabetes is a worldwide epidemic (112). Cardiovascular disease remains the major
cause of morbidity and mortality in people with diabetes. Epidemiological
studies suggest that the prevalence of heart failure exceeds that which can ... Cited by 39 - Related articles - BL Direct - All 5 versions
- ►onlinejacc.org RM Witteles, MB Fowler - Journal of the American College of Cardiology, 2008 - Elsevier Increasing evidence points to insulin resistance as a primary etiologic factor
in the development of nonischemic heart failure (HF). The myocardium normally
responds to injury by altering substrate metabolism to increase energy ... Cited by 38 - Related articles - All 25 versions
ED Abel, SE Litwin, G Sweeney - Physiological Reviews, 2008 - Am Physiological Soc The dramatic increase in the prevalence of obesity and its strong association
with cardiovascular disease have resulted in unprecedented interest in
understanding the effects of obesity on the cardiovascular system. A ... Cited by 25 - Related articles - BL Direct - All 3 versions
F Villarroya, R Iglesias, M Giralt - PPAR research, 2007 - pubmedcentral.nih.gov Uncoupling proteins (UCPs) are mitochondrial membrane transporters involved in
the control of energy conversion in mitochondria. Experimental and genetic
evidence relate dysfunctions of UCPs with metabolic syndrome and obesity. ... Cited by 22 - Related articles - All 4 versions
H Bugger - Clinical Science, 2008 - clinsci.org The metabolic syndrome represents a cluster of abnormalities, including obesity,
insulin resistance, dyslipidaemia and Type 2 diabetes, that increases the risk
of developing cardiovascular diseases, such as coronary artery disease and ... Cited by 13 - Related articles - Cached - BL Direct - All 7 versions
AN Carley, LL Atkinson, A Bonen, ME Harper … - Archives of physiology and biochemistry, 2007 - informahealthcare.com The aim of this study was to determine the biochemical mechanism(s) responsible
for enhanced FA utilization (oxidation and esterification) by perfused hearts
from type 2 diabetic db/db mice. The plasma membrane content of fatty acid ... Cited by 14 - Related articles - BL Direct - All 6 versions
AJ Murray, MA Cole, CA Lygate, CA Carr, DJ … - Journal of Molecular and Cellular Cardiology, 2008 - Elsevier Heart failure patients have abnormal cardiac high energy phosphate metabolism,
the explanation for which is unknown. Patients with heart failure also have
elevated plasma free fatty acid (FFA) concentrations. Elevated FFA levels ... Cited by 12 - Related articles - All 6 versions
