- ►nih.gov [PDF] TA Kinard, G De Vries, A Sherman, LS Satin - Biophysical journal, 1999 - Elsevier Glucose triggers bursting activity in pancreatic islets, which mediates the Ca
2+ uptake that triggers insulin secretion. Aside from the channel mechanism
responsible for bursting, which remains unsettled, it is not clear whether ... Cited by 57 - Related articles - BL Direct - All 12 versions
- ►nih.gov R Bertram, L Satin, M Zhang, P Smolen, A … - Biophysical journal, 2004 - Elsevier Pancreatic islets of Langerhans produce bursts of electrical activity when
exposed to stimulatory glucose levels. These bursts often have a regular
repeating pattern, with a period of 10–60 s. In some cases, however, the ... Cited by 46 - Related articles - BL Direct - All 15 versions
- ►physiology.org R Bertram, A Sherman, LS Satin - American Journal of Physiology- Endocrinology And …, 2007 - Am Physiological Soc Impairment of insulin secretion from the -cells of the pancreatic islets of
Langerhans is central to the development of type 2 diabetes mellitus and has
therefore been the subject of much investigation. Great advances have been ... Cited by 18 - Related articles - BL Direct - All 7 versions
- ►nih.gov CS Nunemaker, R Bertram, A Sherman, K … - Biophysical journal, 2006 - Elsevier Pancreatic islets of Langerhans display complex intracellular calcium changes in
response to glucose that include fast (seconds), slow ( 5 min), and mixed
fast/slow oscillations; the slow and mixed oscillations are likely ... Cited by 16 - Related articles - BL Direct - All 15 versions
- ►physiology.org … , DH Wasserman, OP McGuinness, IR Sweet, … - American Journal of Physiology- Endocrinology And …, 2006 - Am Physiological Soc Islets in most species respond to increased glucose with biphasic insulin
secretion, marked by a sharp first-phase peak and a slowly rising second phase.
Mouse islets in vitro, however, lack a robust second phase. To date, this ... Cited by 14 - Related articles - BL Direct - All 4 versions
- ►nih.gov R Bertram, LS Satin, MG Pedersen, DS … - Biophysical journal, 2007 - Elsevier Insulin secretion from pancreatic β-cells is oscillatory, with a typical period
of 2–7 min, reflecting oscillations in membrane potential and the cytosolic Ca
2+ concentration. Our central hypothesis is that the slow 2–7 min ... Cited by 10 - Related articles - BL Direct - All 17 versions
- ►nih.gov [PDF] IZ Zubrzycki - Biophysical journal, 2002 - Elsevier Sleeping sickness and Chagas disease are among the most severe diseases in
Africa as well as Latin America. These two diseases are caused by Trypanosoma
spp. Recently, an enzyme of a glycolytic pathway, NAD-dependent glycerol-3- ... Cited by 7 - Related articles - BL Direct - All 11 versions
DA Jacobson, LH Philipson - Diabetes Obesity and Metabolism, 2007 - interscience.wiley.com Coordinated electrical activity allows pancreatic β-cells to respond to
secretagogues with calcium entry followed by insulin secretion. Metabolism of
glucose affects multiple membrane proteins including ion channels, ... Cited by 5 - Related articles - All 2 versions
SU Li, MA Chun-yan, Z Yan-dong, JIA Yan- … - Acta Pharmacologica Sinica, 2006 - chinaphar.com Calcium oscillations can, by default, encode diverse and specific signals by
different modes of modulation. Frequency modulation is illustrated by the
activation of calcium/calmodulin-dependent protein kinase II at unit Hz, ... Cited by 3 - Related articles - Cached - BL Direct - All 6 versions
CS Nunemaker, R Bertram, A Sherman, K … - Biophys. J, 2006 - Citeseer Page 1. Glucose Modulates [Ca 21 ] i Oscillations in Pancreatic Islets via
Ionic and Glycolytic Mechanisms Craig S. Nunemaker,* Richard ... Cited by 2 - Related articles - View as HTML - All 3 versions
