- ►uc.pt [PDF] AP Rolo, CM Palmeira - Toxicology and applied pharmacology, 2006 - Elsevier Hyperglycemia resulting from uncontrolled glucose regulation is widely recognized as the causal
link between diabetes and diabetic complications. Four major molecular mechanisms have been
implicated in hyperglycemia-induced tissue damage: activation of protein kinase C (PKC) ... Cited by 120 - Related articles - All 7 versions
- ►nih.gov DB Savage, CS Choi, VT Samuel, ZX Liu, … - Journal of Clinical …, 2006 - Am Soc Clin Investig Hepatic steatosis is a core feature of the metabolic syndrome and type 2 diabetes and leads
to hepatic insulin resistance. Malonyl-CoA, generated by acetyl-CoA carboxylases 1 and 2 (Acc1
and Acc2), is a key regulator of both mitochondrial fatty acid oxidation and fat synthesis. ... Cited by 96 - Related articles - BL Direct - All 13 versions
K Uno, H Katagiri, T Yamada, Y Ishigaki, T Ogihara, J … - Science, 2006 - sciencemag.org Coordinated control of energy metabolism and glucose homeostasis requires communication
between organs and tissues. We identified a neuronal pathway that participates in the cross
talk between the liver and adipose tissue. By studying a mouse model, we showed that ... Cited by 60 - Related articles - BL Direct - All 7 versions
- ►ahajournals.org H Katagiri, T Yamada, Y Oka - Circulation research, 2007 - Am Heart Assoc Obesity, a major healthcare issue, is associated with significant cardiovascular morbidities, including
hypertension and atherosclerosis. Numerous intensive studies conducted this decade have revealed
that adipose tissue is a major endocrine organ that secretes a variety of bioactive ... Cited by 52 - Related articles - All 6 versions
CS Choi, DB Savage, A Kulkarni, XX Yu, ZX Liu, K … - Journal of Biological …, 2007 - ASBMB Nonalcoholic fatty liver disease (NAFLD) is a major contributing factor to hepatic insulin resistance
in type 2 diabetes. Diacylglycerol acyltransferase (Dgat), of which there are two isoforms (Dgat1
and Dgat2), catalyzes the final step in triglyceride synthesis. We evaluated the metabolic ... Cited by 48 - Related articles - All 8 versions
R Buettner, J Schölmerich, LC Bollheimer - Obesity, 2007 - nature.com Research Methods and Procedures: High-fat (HF) diet feeding can induce obesity and metabolic
disorders in rodents that resemble the human metabolic syndrome. However, this dietary intervention
is not standardized, and the HF-induced phenotype varies distinctly among different ... Cited by 40 - Related articles - All 3 versions
T Yamada, H Katagiri, Y Ishigaki, T Ogihara, J Imai, K … - Cell Metabolism, 2006 - Elsevier Intra-abdominal fat accumulation is involved in development of the metabolic syndrome, which
is associated with insulin and leptin resistance. We show here that ectopic expression of very
low levels of uncoupling protein 1 (UCP1) in epididymal fat (Epi) reverses both insulin ... Cited by 40 - Related articles - All 8 versions
- ►endojournals.org M Penza, C Montani, A Romani, P Vignolini, B … - Endocrinology, 2006 - Endocrine Soc The soy isoflavone genistein targets adipose tissue and elicits physiological effects that may
vary based on dietary intake. We hypothesized that the adipose effects of genistein are dose
and gender dependent. Four-week-old C57BL/6 male and female mice received daily ... Cited by 30 - Related articles - BL Direct - All 5 versions
J Gao, H Katagiri, Y Ishigaki, T Yamada, T Ogihara, J … - Diabetes, 2007 - Am Diabetes Assoc Although apolipoprotein E (apoE) is well known to play a major role in lipid metabolism, its role
in glucose and energy homeostasis remains unclear. Herein, we established apoE-deficient
genetically obese Ay (apoE −/− ;Ay/+) mice. ApoE deficiency in Ay mice prevented the ... Cited by 26 - Related articles - BL Direct - All 4 versions
- ►ahajournals.org Y Ishigaki, H Katagiri, J Gao, T Yamada, J Imai, K Uno, … - Circulation, 2008 - Am Heart Assoc Methods and Results— To clarify the atherogenic impact of oxLDL, lectin-like oxLDL receptor
1 (LOX-1), an oxLDL receptor, was expressed ectopically in the liver with adenovirus administration
in apolipoprotein E–deficient mice at 46 weeks of age. Hepatic LOX-1 expression ... Cited by 23 - Related articles - All 8 versions
