T Rankinen, A Zuberi, YC Chagnon, SJ Weisnagel, G … - Obesity, 2006 - pbrc.edu Abstract RANKINEN, TUOMO, AAMIR ZUBERI, YVON C. CHAGNON, S. JOHN
WEISNAGEL, GEORGE ARGYROPOULOS, BRANDON WALTS, LOUIS PE´RUSSE, AND CLAUDE
BOUCHARD. The human obesity gene map: the 2005 update. Obesity. 2006;14: ... Cited by 335 - Related articles - View as HTML - All 6 versions
RJ Dickinson, SM Keyse - Journal of cell science, 2006 - jcs.biologists.org A structurally distinct subfamily of ten dual-specificity (Thr/Tyr) protein phosphatases is responsible
for the regulated dephosphorylation and inactivation of mitogen-activated protein kinase
(MAPK) family members in mammals. These MAPK phosphatases (MKPs) interact ... Cited by 65 - Related articles - BL Direct - All 6 versions
- ►inserm.fr [PDF] F Bost, M Aouadi, L Caron, B Binetruy - Biochimie, 2005 - Elsevier The ERK, p38 and JNK mitogen activated protein kinases (MAPKs) are intracellular signalling
pathways that play a pivotal role in many essential cellular processes such as proliferation and
differentiation. MAPKs are activated by a large variety of stimuli and one of their major ... Cited by 64 - Related articles - All 9 versions
- ►endojournals.org J Jager, T Grémeaux, M Cormont, Y Le Marchand- … - Endocrinology, 2007 - Endocrine Soc Inflammation is associated with obesity and insulin resistance. Proinflammatory cytokines produced
by adipose tissue in obesity could alter insulin signaling and action. Recent studies have shown
a relationship between IL-1ß level and metabolic syndrome or type 2 diabetes. However, ... Cited by 53 - Related articles - BL Direct - All 8 versions
B Fève - Best Practice & Research Clinical Endocrinology & …, 2005 - Elsevier Obesity and lipoatrophy are major risks for insulin resistance, non-insulin-dependent diabetes
and cardiovascular disease. In the past three decades, significant advances have been made
in delineating the key transcription factors of adipogenesis, as well as extracellular ... Cited by 47 - Related articles - All 11 versions
- ►cell.com J Moscat, MT Diaz-Meco, MW Wooten - Trends in Biochemical Sciences, 2007 - Elsevier Signal specificity of multifunctional enzymes is achieved through protein–protein interactions
involving specific domains on scaffold proteins. p62 (also known as sequestosome 1) is such
a scaffold protein that possesses PB1 and UBA domains, and the TRAF6 binding ... Cited by 40 - Related articles - All 5 versions
M Aouadi, B Binetruy, L Caron, Y Le Marchand-Brustel, … - Biochimie, 2006 - Elsevier The ERK, p38MAPK, JNK mitogen-activated protein kinases (MAPKs) are intracellular signaling
pathways that play a pivotal role in many essential cellular processes such as proliferation and
differentiation. These cascades are activated by a large variety of stimuli and display a ... Cited by 44 - Related articles - All 5 versions
JJ Wu, RJ Roth, EJ Anderson, EG Hong, MK Lee, CS … - Cell metabolism, 2006 - Elsevier The mitogen-activated protein kinases (MAPK) play critical roles in the pathogenesis of diabetes
and obesity. The MAPKs are inactivated by MAPK phosphatases (MKPs) either in the cytosol
or nucleus. Here we show that mice lacking the nuclear-localized MKP, MKP-1 (mkp-1 −/− ... Cited by 38 - Related articles - All 11 versions
- ►aspetjournals.org M Bifulco, C Grimaldi, P Gazzerro, S Pisanti, A Santoro - Molecular pharmacology, 2007 - ASPET The advent of the highly selective cannabinoid receptor (CB1) antagonist, rimonabant
(SR141716; Acomplia) can revolutionize the ability of the clinicians to manage obesity.
Large-scale clinical trials have demonstrated that rimonabant therapy can reduce obesity. ... Cited by 34 - Related articles - All 6 versions
- ►diabetesjournals.org M Aouadi, K Laurent, M Prot, Y Le Marchand-Brustel, B … - Diabetes, 2006 - Am Diabetes Assoc Formation of new adipocytes from precursor cells contributes to adipose tissue expansion and
obesity. In this study, we asked whether p38 mitogen-activated protein kinase (MAPK) pathway
regulates normal and pathological adipogenesis. In both dietary and genetically (ob/ob) ... Cited by 36 - Related articles - BL Direct - All 5 versions
