- ►physiology.org SJ Marciniak, D Ron - Physiological reviews, 2006 - Am Physiological Soc The extracellular space is an environment hostile to unmodified polypeptides.
For this reason, many eukaryotic proteins destined for exposure to this
environment through secretion or display at the cell surface require ... Cited by 182 - Related articles - BL Direct - All 6 versions
- ►diabetesjournals.org M Cnop, N Welsh, JC Jonas, A Jörns, S Lenzen … - Diabetes, 2005 - Am Diabetes Assoc Type 1 and type 2 diabetes are characterized by progressive β-cell failure.
Apoptosis is probably the main form of β-cell death in both forms of the
disease. It has been suggested that the mechanisms leading to nutrient- and ... Cited by 174 - Related articles - BL Direct - All 10 versions
- ►endojournals.org DL Eizirik, AK Cardozo, M Cnop - Endocrine Reviews, 2008 - Endocrine Soc Accumulating evidence suggests that endoplasmic reticulum (ER) stress plays a
role in the pathogenesis of diabetes, contributing to pancreatic β-cell loss
and insulin resistance. Components of the unfolded protein response (UPR) ... Cited by 93 - Related articles - BL Direct - All 5 versions
- ►nih.gov K Terai, Y Hiramoto, M Masaki, S Sugiyama, T … - Molecular and Cellular Biology, 2005 - Am Soc Microbiol Oxygen deprivation leads to the accumulation of misfolded proteins in the
endoplasmic reticulum (ER), causing ER stress. Under conditions of ER stress,
inhibition of protein synthesis and up-regulation of ER chaperone ... Cited by 78 - Related articles - BL Direct - All 7 versions
P Marchetti, M Bugliani, R Lupi, L Marselli, M … - Diabetologia, 2007 - Springer Page 1. ARTICLE The endoplasmic reticulum in pancreatic beta cells of type 2 diabetes
patients P. Marchetti & M. Bugliani & R. Lupi & L. Marselli & ... Cited by 47 - Related articles - BL Direct - All 2 versions
- ►jbc.org M Cnop, L Ladriere, P Hekerman, F Ortis, AK … - Journal of Biological Chemistry, 2007 - ASBMB Free fatty acids cause pancreatic -cell apoptosis and may contribute to -cell
loss in type 2 diabetes via the induction of endoplasmic reticulum stress.
Reductions in eukaryotic translation initiation factor (eIF) 2 ... Cited by 44 - Related articles - All 6 versions
- ►endojournals.org D Scheuner, RJ Kaufman - Endocrine Reviews, 2008 - Endocrine Soc The endoplasmic reticulum (ER) is the entry site into the secretory pathway for
newly synthesized proteins destined for the cell surface or released into the
extracellular milieu. The study of protein folding and trafficking within ... Cited by 38 - Related articles - BL Direct - All 5 versions
- ►ucsf.edu [PDF] JH Lin, P Walter, TSB Yen, 2008 - Annual Reviews The endoplasmic reticulum (ER) is the site of synthesis and folding of membrane
and secretory proteins, which, collectively, represent a large fraction of the
total protein output of a mammalian cell. Therefore, the protein flux ... Cited by 37 - Related articles - BL Direct - All 6 versions
- ►oxfordjournals.org W Lin, A Kemper, JL Dupree, HP Harding, D … - Brain, 2006 - Oxford Univ Press Interferon- (IFN- ) is believed to play a deleterious role in the
immune-mediated demyelinating disorder multiple sclerosis. Here we have
exploited transgenic mice that ectopically express IFN- in a temporally ... Cited by 30 - Related articles - BL Direct - All 5 versions
- ►endojournals.org F Ortis, AK Cardozo, D Crispim, J Storling, T … - Molecular Endocrinology, 2006 - Endocrine Soc Cytokines, such as IL-1ß and TNF- , contribute to pancreatic ß-cell death in
type 1 diabetes mellitus. The transcription factor nuclear factor- B (NF- B)
mediates cytokine-induced ß-cell apoptosis. Paradoxically, NF- B has ... Cited by 31 - Related articles - BL Direct - All 6 versions
