DJ Drucker, MA Nauck - The Lancet, 2006 - Elsevier Glucagon-like peptide 1 (GLP-1) is a gut-derived incretin hormone that stimulates insulin and
suppresses glucagon secretion, inhibits gastric emptying, and reduces appetite and food
intake. Therapeutic approaches for enhancing incretin action include ... Cited by 416 - Related articles - All 10 versions
- ►rh.dk [PDF] LL Baggio, DJ Drucker - Gastroenterology, 2007 - Elsevier This review focuses on the mechanisms regulating the synthesis, secretion, biological
actions, and therapeutic relevance of the incretin peptides glucose-dependent insulinotropic
polypeptide (GIP) and glucagon-like peptide-1 (GLP-1). The published literature was ... Cited by 179 - Related articles - All 25 versions
- ►physiology.org JJ Holst - Physiological reviews, 2007 - Am Physiological Soc Glucagon-like peptide 1 (GLP-1) is a 30-amino acid peptide hormone produced in the intestinal
epithelial endocrine L-cells by differential processing of proglucagon, the gene which is expressed
in these cells. The current knowledge regarding regulation of proglucagon gene ... Cited by 119 - Related articles - BL Direct - All 5 versions
- ►endojournals.org J Gromada, I Franklin, CB Wollheim - Endocrine reviews, 2007 - Endocrine Soc Glucagon, a hormone secreted from the -cells of the endocrine pancreas, is critical for blood
glucose homeostasis. It is the major counterpart to insulin and is released during hypoglycemia
to induce hepatic glucose output. The control of glucagon secretion is multifactorial and ... Cited by 61 - Related articles - BL Direct - All 4 versions
- ►diabetesjournals.org K Maedler, DM Schumann, N Sauter, H Ellingsgaard, D … - Diabetes, 2006 - Am Diabetes Assoc High glucose concentrations have a dual effect on β-cell turnover, inducing proliferation in the
short-term and apoptosis in the long-term. Hyperglycemia leads to β-cell production of interleuking
(IL)-1β in human pancreatic islets. Fas, a death receptor regulated by IL-1β, is involved in ... Cited by 31 - Related articles - BL Direct - All 4 versions
- ►diabetesjournals.org K Maedler, DM Schumann, F Schulthess, J Oberholzer, … - Diabetes, 2006 - Am Diabetes Assoc Type 2 diabetes is characterized by a deficit in β-cell mass, and its incidence increases with
age. Here, we analyzed β-cell turnover in islets from 2- to 3- compared with 7- to 8-month-old
rats and in human islets from 53 organ donors with ages ranging from 17 to 74 years. In ... Cited by 29 - Related articles - BL Direct - All 4 versions
- ►diabetesjournals.org R Granata, F Settanni, D Gallo, L Trovato, L Biancone, … - Diabetes, 2008 - Am Diabetes Assoc RESULTS—Obestatin showed specific binding on HIT-T15 and INS-1E β-cells, bound to
glucagon-like peptide-1 receptor (GLP-1R), and recognized ghrelin binding sites. Obestatin exerted
proliferative, survival, and antiapoptotic effects under serum-deprived conditions and ... Cited by 27 - Related articles - BL Direct - All 3 versions
J Chen, FM Couto, AH Minn, A Shalev - Biochemical and Biophysical Research …, 2006 - Elsevier Exenatide (Ex-4) is a novel anti-diabetic drug that stimulates insulin secretion and enhances
β-cell mass, but the mechanisms involved are not fully understood. We found that Ex-4 protects
INS-1 β-cells against oxidative stress-induced apoptosis (TUNEL) and also reduces ... Cited by 26 - Related articles - All 6 versions
C Alarcon, B Wicksteed, CJ Rhodes - Diabetologia, 2006 - Springer Abstract Aims/hypothesis Ideally, a therapeutic insulin secretagogue should coordinately increase
insulin production and insulin secretion to maintain islet beta cell secretory capacity. We compared
the incretin mimetic exendin 4 and the sulfonylurea glibenclamide (known as glyburide in ... Cited by 21 - Related articles - BL Direct - All 4 versions
- ►endojournals.org MY Donath, J Storling, LA Berchtold, N Billestrup, T … - Endocrine …, 2008 - Endocrine Soc The tale of cytokines and the β-cell is a long story, starting with in vitro discovery in 1984, evolving
via descriptive and phenomenological studies to detailed mapping of the signalling
pathways, gene- and protein expression patterns, molecular and biochemical effector ... Cited by 21 - Related articles - BL Direct - All 6 versions
