- ►biologists.org H Wang, G Kouri, CB Wollheim - Journal of cell science, 2005 - jcs.biologists.org The reduction in insulin secretory capacity and ß-cell mass observed in type 2 diabetes is thought
to be caused by glucolipotoxicity secondary to hyperglycemia and hyperlipidemia. Our aim in
this study was to elucidate the underlying molecular mechanisms. We found a strong ... Cited by 104 - Related articles - BL Direct - All 7 versions
G Mattiasson, PG Sullivan - Antioxidants & Redox Signaling, 2006 - liebertonline.com 1 Laboratory for Experimental Brain Research, Wallenberg Neuroscience Center, Lund,
Sweden. 2 Spinal Cord and Brain Injury Research Center and 3 Department of Anatomy and
Neurobiology University of Kentucky, Lexington, Kentucky. ... The Emerging Functions of ... Cited by 41 - Related articles - BL Direct - All 3 versions
- ►endojournals.org H Zitzer, W Wente, MB Brenner, S Sewing, K Buschard, … - Endocrinology, 2006 - Endocrine Soc Liver X receptors (LXR and LXRß) regulate glucose and lipid metabolism. Pancreatic ß-cells
and INS-1E insulinoma cells express only the LXRß isoform. Activation of LXRß with the synthetic
agonist T0901317 increased glucose-induced insulin secretion and insulin content, ... Cited by 23 - Related articles - BL Direct - All 4 versions
- ►diabetesjournals.org SS Choe, AH Choi, JW Lee, KH Kim, JJ Chung, J Park, … - Diabetes, 2007 - Am Diabetes Assoc Liver X receptor (LXR)α and LXRβ play important roles in fatty acid metabolism and cholesterol
homeostasis. Although the functional roles of LXR in the liver, intestine, fat, and macrophages
are well established, its role in pancreatic β-cells has not been clearly defined. In this ... Cited by 23 - Related articles - BL Direct - All 6 versions
- ►physiology.org LE Parton, PJ McMillen, Y Shen, E … - American Journal of …, 2006 - Am Physiological Soc Accumulation of intracellular lipid may contribute to defective insulin secretion in type 2
diabetes. Although Zucker diabetic fatty (ZDF; fa/fa) rat islets are fat-laden and overexpress the
lipogenic master gene, sterol regulatory element binding protein 1c (SREBP-1c), the ... Cited by 17 - Related articles - BL Direct - All 3 versions
- ►endojournals.org H Oberkofler, K Klein, TK Felder, F Krempler, W Patsch - Endocrinology, 2006 - Endocrine Soc A role of uncoupling protein 2 (UCP2) as negative modulator of insulin secretion has been
suggested, but the transcriptional pathways regulating ß-cell UCP2 gene expression have been
established in rodents only. We show here that the underlying sequence motifs are not ... Cited by 16 - Related articles - BL Direct - All 3 versions
H Shimano - Journal of Molecular Medicine, 2007 - Springer Abstract Genes involved in carbohydrate and lipid metab- olism are nutritionally regulated at
the transcriptional level in a coordinated fashion. SREBP-1c is a bHLH transcrip- tion factor that
controls lipogenesis and is induced during overnutrition to facilitate the conversion of ... Cited by 14 - Related articles - BL Direct - All 5 versions
- ►jbc.org M Amemiya-Kudo, J Oka, T Ide, T Matsuzaka, H … - Journal of Biological …, 2005 - ASBMB Insulin gene expression is regulated by pancreatic cell-specific factors, PDX-1 and
BETA2/E47. Here we have demonstrated that the insulin promoter is a novel target for SREBPs
established as lipid-synthetic transcription factors. Promoter analyses of rat insulin I gene ... Cited by 14 - Related articles - BL Direct - All 7 versions
C Affourtit, MD Brand - BBA-Bioenergetics, 2008 - Elsevier Pancreatic beta cells secrete insulin when blood glucose levels are high. Dysfunction of this
glucose-stimulated insulin secretion (GSIS) is partly responsible for the manifestation of type
2 diabetes, a metabolic disorder that is rapidly becoming a global pandemic. ... Cited by 13 - Related articles - All 2 versions
