S Boudina, ED Abel - Circulation, 2007 - Am Heart Assoc The prevalence of diabetes mellitus is growing rapidly. It is estimated that
globally the number of adults affected with diabetes will increase from 135
million in 1995 to 300 million by 2025. 1 Patients with diabetes mellitus ... Cited by 136 - Related articles - All 5 versions
- ►ahajournals.org JD Brown, J Plutzky - Circulation, 2007 - Am Heart Assoc Peroxisome proliferator–activated receptors (PPARs) are ligand-activated
transcription factors involved in the transcriptional regulation of key
metabolic pathways such as lipid metabolism, adipogenesis, and insulin ... Cited by 104 - Related articles - All 8 versions
- ►nih.gov RS Jope, CJ Yuskaitis, E Beurel - Neurochemical research, 2007 - Springer Abstract Deciphering what governs inflammation and its effects on tissues is
vital for understanding many pathologies. The recent discovery that glycogen
synthase kinase-3 (GSK3) promotes inflammation reveals a new component of ... Cited by 72 - Related articles - BL Direct - All 5 versions
D An, B Rodrigues - American Journal of Physiology- Heart and Circulatory …, 2006 - Am Physiological Soc In patients with diabetes, an increased risk of symptomatic heart failure
usually develops in the presence of hypertension or ischemic heart disease.
However, a predisposition to heart failure might also reflect the effects ... Cited by 66 - Related articles - BL Direct - All 5 versions
JC Russell, SD Proctor - Cardiovascular pathology, 2006 - Elsevier Cardiovascular disease, the leading cause of death in much of the modern world,
is the common symptomatic end stage of a number of distinct diseases and,
therefore, is multifactorial and polygenetic in character. The two major ... Cited by 37 - Related articles - All 11 versions
- ►physiology.org Y Ye, Y Lin, S Atar, MH Huang, JR Perez-Polo … - American Journal of Physiology- Heart and Circulatory …, 2006 - Am Physiological Soc We assessed 1) whether pretreatment before ischemia with pioglitazone (Pio)
limits infarct size (IS) and whether this protective effect is due to nitric
oxide synthase (NOS) and/or prostaglandin production, as has been shown for ... Cited by 35 - Related articles - BL Direct - All 3 versions
ED Abel, SE Litwin, G Sweeney - Physiological Reviews, 2008 - Am Physiological Soc The dramatic increase in the prevalence of obesity and its strong association
with cardiovascular disease have resulted in unprecedented interest in
understanding the effects of obesity on the cardiovascular system. A ... Cited by 25 - Related articles - BL Direct - All 3 versions
- ►ahajournals.org GD Lopaschuk, CDL Folmes, WC Stanley - Circulation Research, 2007 - Am Heart Assoc Obesity results in marked alterations in cardiac energy metabolism, with a
prominent effect being an increase in fatty acid uptake and oxidation by the
heart. Obesity also results in dramatic changes in the release of ... Cited by 24 - Related articles - All 16 versions
- ►nih.gov B Clodfelder-Miller, P De Sarno, AA … - Journal of Biological Chemistry, 2005 - ASBMB Insulin regulates the phosphorylation and activities of Akt and glycogen
synthase kinase-3 (GSK3) in peripheral tissues, but in the brain it is less
clear how this signaling pathway is regulated in vivo and whether it is ... Cited by 22 - Related articles - BL Direct - All 6 versions
A Elsässer, H Möllmann, HM Nef, CW Hamm - Clinical Research in Cardiology, 2006 - Springer Diabetes mellitus (DM) is a common illness with significant cardiovascular
importance. Recent esti- mates give a number of more than 150 million adults
worldwide suffering from DM [11]. Type 2 DM ac- counts for up to 95% of all ... Cited by 16 - Related articles - All 3 versions
