PD Gluckman, MA Hanson, AS Beedle - American Journal of Human …, 2007 - pinniped.net PETER D. GLUCKMAN,1,2* MARK A. HANSON,2 AND ALAN S. BEEDLE1 1Liggins
Institute, University of Auckland, and National Research Centre for Growth and
Development, Private Bag 92019, Auckland, New Zealand 2Centre for Developmental ... Cited by 90 - Related articles - View as HTML - BL Direct - All 6 versions
- ►endojournals.org DL Eizirik, AK Cardozo, M Cnop - Endocrine Reviews, 2008 - Endocrine Soc Accumulating evidence suggests that endoplasmic reticulum (ER) stress plays a role in the pathogenesis
of diabetes, contributing to pancreatic β-cell loss and insulin resistance. Components of the unfolded
protein response (UPR) play a dual role in β-cells, acting as beneficial regulators under ... Cited by 93 - Related articles - BL Direct - All 5 versions
D Porte, DG Baskin, MW Schwartz - Diabetes, 2005 - Am Diabetes Assoc Insulin and its signaling systems are implicated in both central and peripheral mechanisms governing
the ingestion, distribution, metabolism, and storage of nutrients in organisms ranging from worms
to humans. Input from the environment regarding the availability and type of nutrients is ... Cited by 77 - Related articles - All 8 versions
- ►diabetesjournals.org W Winckler, MN Weedon, RR Graham, SA McCarroll, S … - Diabetes, 2007 - Am Diabetes Assoc An important question in human genetics is the extent to which genes causing monogenic forms
of disease harbor common variants that may contribute to the more typical form of that
disease. We aimed to comprehensively evaluate the extent to which common variation in ... Cited by 56 - Related articles - BL Direct - All 5 versions
DB Dunger, CJ Petry, KK Ong - Horm Res, 2006 - content.karger.com Size at birth is said to be a highly heritable trait, with an estimated 30-70% of the variability a
result of genetics. Data from family studies may be confounded, however, by potential interactions
between fetal genes and the maternal uterine environment. Overall, the maternal ... Cited by 45 - Related articles - BL Direct - All 5 versions
- ►nih.gov RM Freathy, MN Weedon, A Bennett, E Hyppönen, … - The American Journal of …, 2007 - Elsevier The role of genes in normal birth-weight variation is poorly understood, and it has been suggested
that the genetic component of fetal growth is small. Type 2 diabetes genes may influence birth
weight through maternal genotype, by increasing maternal glycemia in pregnancy, or ... Cited by 43 - Related articles - BL Direct - All 9 versions
AT Hattersley, ER Pearson - Endocrinology, 2006 - Endocrine Soc Defining the molecular genetics of diabetes gives new insight into the underlying etiology and
so should help improve treatment. The genetic etiology is now known for most patients with
ß-cell monogenic diabetes, allowing genetic classification. We review how this genetic ... Cited by 43 - Related articles - BL Direct - All 8 versions
- ►nih.gov MN Weedon, VJ Clark, Y Qian, Y Ben-Shlomo, N … - The American Journal of …, 2006 - Elsevier Fasting glucose is associated with future risk of type 2 diabetes and ischemic heart disease and
is tightly regulated despite considerable variation in quantity, type, and timing of food intake.
In pregnancy, maternal fasting glucose concentration is an important determinant of ... Cited by 35 - Related articles - BL Direct - All 13 versions
- ►nih.gov MI McCarthy, E Zeggini - Current Diabetes Reports, 2006 - Springer Introduction The growing prevalence of type 2 diabetes and obesity in societies worldwide is
widely recognized as among the greatest threats to global health in the coming century [1].
Nevertheless, we remain far from a comprehensive understanding of the molecular ... Cited by 31 - Related articles - BL Direct - All 8 versions
M Vaxillaire, P Froguel - Endocrinology and metabolism clinics of North America, 2006 - Elsevier Type 2 diabetes mellitus (T2D) is a heterogeneous metabolic disease occurring with concomitant
or interdependent defects of insulin secretion and action [1] and [2]. It generally is accepted that
T2D results from a complex interplay of genetic and environmental factors influencing ... Cited by 30 - Related articles - All 4 versions
