N Houstis, ED Rosen, ES Lander - Nature, 2006 - cns-alumni.bu.edu Insulin resistance is a cardinal feature of type 2 diabetes and is
characteristic of a wide range of other clinical and experimental settings.
Little is known about why insulin resistance occurs in so many contexts. Do ... Cited by 352 - Related articles - View as HTML - BL Direct - All 9 versions
- ►physiology.org JS Lee, SK Pinnamaneni, SJ Eo, IH Cho, JH … - Journal of applied physiology, 2006 - Am Physiological Soc Consumption of a Western diet rich in saturated fats is associated with obesity
and insulin resistance. In some insulin-resistant phenotypes this is associated
with accumulation of skeletal muscle fatty acids. We examined the effects ... Cited by 60 - Related articles - BL Direct - All 9 versions
DK Hagman, LB Hays, SD Parazzoli, V … - Journal of Biological Chemistry, 2005 - ASBMB Abnormalities in lipid metabolism have been proposed as contributing factors to
both defective insulin secretion from the pancreatic beta cell and peripheral
insulin resistance in type 2 diabetes. Previously, we have shown that ... Cited by 42 - Related articles - BL Direct - All 10 versions
H Zhao, M Przybylska, I Wu… - Diabetes, 2007 - Am Diabetes Assoc Previous reports have shown that glycosphingolipids can modulate the activity of
the insulin receptor, and studies in transgenic mice suggest a link between
altered levels of various gangliosides and the development of insulin ... Cited by 29 - Related articles - BL Direct - All 6 versions
F Samad, KD Hester, G Yang, YA Hannun, J … - Diabetes, 2006 - Am Diabetes Assoc The adipose tissue has become a central focus in the pathogenesis of
obesity-mediated cardiovascular and metabolic disease. Here we demonstrate that
adipose sphingolipid metabolism is altered in genetically obese (ob/ob) ... Cited by 23 - Related articles - BL Direct - All 5 versions
- ►physiology.org SM Turpin, GI Lancaster, I Darby, MA … - American Journal of Physiology- Endocrinology And …, 2006 - Am Physiological Soc Fatty acid-induced apoptosis occurs in pancreatic -cells and contributes to the
metabolic syndrome. Skeletal muscle insulin resistance is mediated by fatty acid
oversupply, which also contributes to the metabolic syndrome. Therefore, we ... Cited by 23 - Related articles - BL Direct - All 3 versions
H Bays, C Ballantyne - Future Lipidol., 2006 - Future Medicine In the adipocentric paradigm, fat health affects patient health. Adiposopathy
('pathos' of adipose tissue or fat dysfunction) is more directly associated with
excessive fat-related metabolic disease (EFRMD) than adiposity (increased ... Cited by 23 - Related articles - BL Direct - All 3 versions
M Straczkowski, I Kowalska, M Baranowski, A … - Diabetologia, 2007 - Springer Page 1. ARTICLE Increased skeletal muscle ceramide level in men at risk of developing
type 2 diabetes M. Straczkowski & I. Kowalska & M. Baranowski & ... Cited by 19 - Related articles - BL Direct - All 3 versions
D Cheng - Nutrition & Metabolism, 2005 - biomedcentral.com Abstract In 2000, more than 151 million people in the world are diabetic. It is
predicted that by 2010, 221 million people and by 2025, 324 million will be
diabetic. In the US, for the population born in 2000, the estimated ... Cited by 17 - Related articles - View as HTML - All 13 versions
