R Belfort, SA Harrison, K Brown, C Darland, J … - New England Journal …, 2006 - content.nejm.org Methods We randomly assigned 55 patients with impaired glucose tolerance or type 2 diabetes
and liver biopsy–confirmed nonalcoholic steatohepatitis to 6 months of treatment with a hypocaloric
diet (a reduction of 500 kcal per day in relation to the calculated daily intake required to ... Cited by 386 - Related articles - BL Direct - All 7 versions
- ►peoriaendocrine.com [PDF] KF Petersen, GI Shulman - The American journal of medicine, 2006 - Elsevier Type 2 diabetes mellitus is a major cause of morbidity and mortality worldwide, and the prevalence
is set to increase dramatically over the coming decades. Understanding the metabolic pathways
that lead to type 2 diabetes is therefore an important healthcare objective. Novel ... Cited by 210 - Related articles - All 11 versions
- ►diabetesjournals.org K Morino, KF Petersen, GI Shulman - Diabetes, 2006 - Am Diabetes Assoc Recent studies using magnetic resonance spectroscopy have shown that decreased
insulin-stimulated muscle glycogen synthesis due to a defect in insulin-stimulated glucose transport
activity is a major factor in the pathogenesis of type 2 diabetes. The molecular mechanism ... Cited by 125 - Related articles - BL Direct - All 5 versions
- ►endojournals.org KM Utzschneider, SE Kahn - Journal of Clinical Endocrinology & …, 2006 - Endocrine Soc Evidence Synthesis: Insulin resistance in NAFLD is characterized by reductions in
whole-body, hepatic, and adipose tissue insulin sensitivity. The mechanisms underlying the accumulation
of fat in the liver may include excess dietary fat, increased delivery of free fatty acids to the ... Cited by 116 - Related articles - BL Direct - All 4 versions
- ►physiology.org DB Savage, KF Petersen, GI Shulman - Physiological reviews, 2007 - Am Physiological Soc Although abnormal glucose metabolism defines type 2 diabetes mellitus (T2DM) and accounts
for many of its symptoms and complications, efforts to understand the pathogenesis of T2DM
are increasingly focused on disordered lipid metabolism. Here we review recent human ... Cited by 113 - Related articles - BL Direct - All 5 versions
AL Carey, GR Steinberg, SL Macaulay, WG Thomas, … - Diabetes, 2006 - Am Diabetes Assoc Although interleukin-6 (IL-6) has been associated with insulin resistance, little is known regarding
the effects of IL-6 on insulin sensitivity in humans in vivo. Here, we show that IL-6 infusion increases
glucose disposal without affecting the complete suppression of endogenous glucose ... Cited by 99 - Related articles - BL Direct - All 6 versions
- ►nih.gov DB Savage, CS Choi, VT Samuel, ZX Liu, … - Journal of Clinical …, 2006 - Am Soc Clin Investig Hepatic steatosis is a core feature of the metabolic syndrome and type 2 diabetes and leads
to hepatic insulin resistance. Malonyl-CoA, generated by acetyl-CoA carboxylases 1 and 2 (Acc1
and Acc2), is a key regulator of both mitochondrial fatty acid oxidation and fat synthesis. ... Cited by 96 - Related articles - BL Direct - All 13 versions
G Targher, G Arcaro - Atherosclerosis, 2007 - Elsevier Non-alcoholic fatty liver disease (NAFLD) is present in up to one-third of the general population
and in the majority of patients with cardio-metabolic risk factors such as abdominal obesity, type
2 diabetes and other components of the metabolic syndrome (MetS). Currently, the ... Cited by 89 - Related articles - All 18 versions
S Klein, B Mittendorfer, JC Eagon, B Patterson, LF … - Gastroenterology, 2006 - Elsevier Background & Aims: Most patients with extreme obesity have nonalcoholic fatty liver disease
(NAFLD). Although gastric bypass (GBP) surgery is the most common bariatric operation performed
in obese patients in the United States, the effect of GBP surgery-induced weight loss on ... Cited by 84 - Related articles - All 27 versions
- ►cell.com S Neschen, K Morino, LE Hammond, D Zhang, ZX Liu, … - Cell metabolism, 2005 - Elsevier In order to investigate the role of mitochondrial acyl-CoA:glycerol-sn-3-phosphate acyltransferase
1 (mtGPAT1) in the pathogenesis of hepatic steatosis and hepatic insulin resistance, we examined
whole-body insulin action in awake mtGPAT1 knockout (mtGPAT1 −/− ) and wild-type (wt) ... Cited by 77 - Related articles - All 10 versions
