L Chang, SH Chiang, AR Saltiel - Molecular Medicine, 2004 - pubmedcentral.nih.gov Gaps remain in our understanding of the precise molecular mechanisms by which insulin regulates
glucose uptake in fat and muscle cells. Recent evidence suggests that insulin action involves
multiple pathways, each compartmentalized in discrete domains. Upon activation, the ... Cited by 85 - Related articles - BL Direct - All 7 versions
- ►nih.gov JC Hou, JE Pessin - Current opinion in cell biology, 2007 - Elsevier Glucose transporter 4 (GLUT4) is the major insulin-regulated glucose transporter expressed
mainly in muscle and adipose tissue. GLUT4 is stored in a poorly characterized intracellular
vesicular compartment and translocates to the cell surface in response to insulin ... Cited by 29 - Related articles - All 5 versions
- ►jbc.org E Oh, DC Thurmond - Journal of Biological Chemistry, 2006 - ASBMB Stimulus-induced tyrosine phosphorylation of Munc18c was investigated as a potential regulatory
mechanism by which the Munc18c-Syntaxin 4 complex can be dissociated in response to divergent
stimuli in multiple cell types. Use of [ 32 P]orthophosphate incorporation, pervanadate ... Cited by 21 - Related articles - BL Direct - All 6 versions
- ►endojournals.org BA Spurlin, DC Thurmond - Molecular Endocrinology, 2006 - Endocrine Soc Numerous overexpression studies have recently implicated Syntaxin 4 as an effector of insulin
secretion, although its requirement in insulin granule exocytosis is unknown. To address
this, islets from Syntaxin 4 heterozygous (–/+) knockout mice were isolated and compared ... Cited by 22 - Related articles - BL Direct - All 4 versions
LI Cosen-Binker, PPL Lam, MG Binker, J Reeve, S … - Journal of Biological …, 2007 - ASBMB The pancreatic acinus is the functional unit of the exocrine pancreas whose role is to secrete
zymogens into the gut lumen for food digestion via apical exocytosis. We previously reported
that supramaximal CCK induced apical blockade and redirected exocytosis to ectopic ... Cited by 13 - Related articles - All 6 versions
B Ke, E Oh, DC Thurmond - Journal of Biological Chemistry, 2007 - ASBMB The widely expressed Sec/Munc18 (SM) protein Munc18c is required for SNARE-mediated insulin
granule exocytosis from islet beta cells and GLUT4 vesicle exocytosis in skeletal muscle and
adipocytes. Although Munc18c function is known to involve binding to the t-SNARE ... Cited by 10 - Related articles - All 5 versions
C Nevado, AM Valverde, M Benito - Endocrinology, 2006 - Endocrine Soc The liver plays a major role in the regulation of glucose homoeostasis. Evidence from liver-specific
insulin receptor knockout mice (LIRKO) suggested that insulin's direct and indirect effects on
glucose utilization by the liver both require the presence of hepatic insulin receptors (IR). ... Cited by 8 - Related articles - BL Direct - All 4 versions
- ►molbiolcell.org L Arunachalam, L Han, NG Tassew, Y He, L … - Molecular Biology of …, 2008 - Am Soc Cell Biol Although Munc18-1 was originally identified as a syntaxin1–interacting protein, the physiological
significance of this interaction remains unclear. In fact, recent studies of Munc18-1 mutants have
suggested that Munc18-1 plays a critical role for docking of secretory vesicles, ... Cited by 8 - Related articles - All 7 versions
LI Cosen–Binker, PPL Lam, MG Binker, HY Gaisano - Gastroenterology, 2007 - Elsevier Background & Aims: Acute or chronic alcohol treatment does little to the exocrine pancreas but
predisposes the pancreas to postprandial cholinergic stimulation that triggers cellular events
leading to pancreatitis. This alcohol-induced susceptibility mechanism of pancreatitis is ... Cited by 8 - Related articles - All 33 versions
- ►molbiolcell.org [PDF] DB Berry, AP Gasch - Molecular biology of the cell, 2008 - Am Soc Cell Biol Page 1. Protein kinases Fpk1p and Fpk2p are novel regulators of phospholipid asymmetry Kenzi
Nakano*, Takaharu Yamamoto † , Takuma Kishimoto*, Takehiro Noji*, and Kazuma Tanaka †
Division of Molecular Interaction, Institute for Genetic Medicine, Hokkaido University ... Cited by 7 - Related articles - All 6 versions
