- ►nih.gov KE Wellen, GS Hotamisligil - Journal of Clinical Investigation, 2005 - Am Soc Clin Investig Over the last decade, an abundance of evidence has emerged demonstrating a close link between
metabolism and immunity. It is now clear that obesity is associated with a state of chronic
low-level inflammation. In this article, we discuss the molecular and cellular ... Cited by 789 - Related articles - All 15 versions
GS Hotamisligil… - NATURE-LONDON-, 2006 - cms1.daegu.ac.kr The incidence of obesity worldwide has increased drastically during recent decades.
Consequently, obesity and associated disorders now constitute a serious threat to the current
and future health of all popu- lations on Earth. The World Health Organization estimates ... Cited by 587 - Related articles - View as HTML - BL Direct - All 15 versions
U Ozcan, E Yilmaz, L Ozcan, M Furuhashi, E … - Science, 2006 - sciencemag.org Endoplasmic reticulum (ER) stress is a key link between obesity, insulin resistance, and type
2 diabetes. Here, we provide evidence that this mechanistic link can be exploited for therapeutic
purposes with orally active chemical chaperones. 4-Phenyl butyric acid and taurine- ... Cited by 276 - Related articles - BL Direct - All 8 versions
- ►physiology.org SJ Marciniak, D Ron - Physiological reviews, 2006 - Am Physiological Soc The extracellular space is an environment hostile to unmodified polypeptides. For this
reason, many eukaryotic proteins destined for exposure to this environment through secretion
or display at the cell surface require maturation steps within a specialized organelle, the ... Cited by 182 - Related articles - BL Direct - All 6 versions
- ►diabetesjournals.org GS Hotamisligil - Diabetes, 2005 - Am Diabetes Assoc Metabolic and immune systems are the most fundamental requirements for survival, and many
metabolic and immune response pathways or nutrient- and pathogen-sensing systems have
been evolutionarily highly conserved. Consequently, metabolic and immune pathways ... Cited by 106 - Related articles - BL Direct - All 7 versions
- ►endojournals.org DL Eizirik, AK Cardozo, M Cnop - Endocrine Reviews, 2008 - Endocrine Soc Accumulating evidence suggests that endoplasmic reticulum (ER) stress plays a role in the pathogenesis
of diabetes, contributing to pancreatic β-cell loss and insulin resistance. Components of the unfolded
protein response (UPR) play a dual role in β-cells, acting as beneficial regulators under ... Cited by 93 - Related articles - BL Direct - All 5 versions
- ►jlr.org MF Gregor, GS Hotamisligil - The Journal of Lipid Research, 2007 - ASBMB In the context of obesity and its related maladies, the adipocyte plays a central role in the
balance, or imbalance, of metabolic homeostasis. An obese, hypertrophic adipocyte is challenged
by many insults, including surplus energy, inflammation, insulin resistance, and ... Cited by 78 - Related articles - All 5 versions
B Antuna-Puente, B Feve, S Fellahi, JP Bastard - Diabetes and Metabolism, 2008 - Elsevier White adipose tissue was believed to be just an energy-storage organ, but it is now recognized
to be an active participant in energy homoeostasis and physiological functions such as immunity
and inflammation. Macrophages are components of adipose tissue and actively ... Cited by 51 - Related articles - BL Direct - All 3 versions
IA Leclercq, A Da Silva Morais, B Schroyen, N Van Hul, … - Journal of hepatology, 2007 - Elsevier Very few studies have addressed insulin resistance in sinusoidal liver cells. These cells are not
simply bystanders and passive witnesses of the changes affecting the hepatocytes. They are
target cells that will respond to the pathological alterations occurring in the insulin ... Cited by 40 - Related articles - All 6 versions
- ►endojournals.org D Scheuner, RJ Kaufman - Endocrine Reviews, 2008 - Endocrine Soc The endoplasmic reticulum (ER) is the entry site into the secretory pathway for newly synthesized
proteins destined for the cell surface or released into the extracellular milieu. The study of protein
folding and trafficking within the ER is an extremely active area of research that has ... Cited by 38 - Related articles - BL Direct - All 5 versions
