- ►nih.gov M Prentki, CJ Nolan - Journal of Clinical Investigation, 2006 - Am Soc Clin Investig The major focus of this Review is on the mechanisms of islet β cell failure in
the pathogenesis of obesity-associated type 2 diabetes (T2D). As this demise
occurs within the context of β cell compensation for insulin resistance, ... Cited by 196 - Related articles - BL Direct - All 7 versions
- ►endojournals.org SW Limesand, PJ Rozance, GO Zerbe, JC … - Endocrinology, 2006 - Endocrine Soc We determined in vivo and in vitro pancreatic islet insulin secretion and
glucose metabolism in fetuses with intrauterine growth restriction (IUGR) caused
by chronic placental insufficiency to identify functional deficits in the ... Cited by 28 - Related articles - BL Direct - All 5 versions
PM Vuguin - Horm Res, 2007 - content.karger.com Fetal growth retardation is a fetal adaptation in response to inadequate supply
of oxygen and/or nutrients. Animal models of intrauterine growth retardation are
an invaluable tool to question the genetic, molecularand cellular events ... Cited by 23 - Related articles - BL Direct - All 6 versions
JC Jimenez-Chillaron, M Hernandez-Valencia, … - Diabetologia, 2006 - Springer Page 1. ARTICLE Reductions in caloric intake and early postnatal growth prevent
glucose intolerance and obesity associated with low birthweight ... Cited by 21 - Related articles - BL Direct - All 3 versions
- ►jbc.org V Koshkin, FF Dai, CA Robson-Doucette, CB … - Journal of Biological Chemistry, 2008 - ASBMB Involvement of the mitochondrial permeability transition (MPT) pore in early
stages of lipotoxic stress in the pancreatic β-cell lines MIN6 and INS-1 was
the focus of this study. Both long term (indirect) and acute (direct) ... Cited by 9 - Related articles - All 4 versions
R Quintens, N Hendrickx, K Lemaire, F Schuit - Biochemical Society Transactions, 2008 - biochemsoctrans.org A differentiated β-cell results not only from cell-specific gene expression,
but also from cell-selective repression of certain housekeeping genes. Indeed,
to prevent insulin toxicity, β-cells should handle insulin stores ... Cited by 7 - Related articles - Cached - BL Direct - All 5 versions
M del Carmen Miñana-Solis, C Escobar - International Journal of Biological Sciences, 2007 - pubmedcentral.nih.gov Early malnutrition during gestation and lactation modifies growth and metabolism
permanently. Follow up studies using a nutritional rehabilitation protocol have
reported that early malnourished rats exhibit hyperglycemia and/or ... Cited by 5 - Related articles - All 13 versions
JC Jimenez-Chillaron, E Isganaitis, M … - Diabetes, 2009 - Am Diabetes Assoc OBJECTIVE—Low birth weight (LBW) is associated with increased risk of obesity,
diabetes, and cardiovascular disease during adult life. Moreover, this
programmed disease risk can progress to subsequent generations. We ... Cited by 4 - Related articles - All 3 versions
- ►physiology.org J Movassat, D Bailbe, C Lubrano-Berthelier, F … - American Journal of Physiology- Endocrinology And …, 2008 - Am Physiological Soc The adult Goto-Kakizaki (GK) rat is characterized by impaired glucose-induced
insulin secretion in vivo and in vitro, decreased β-cell mass, decreased
insulin sensitivity in the liver, and moderate insulin resistance in ... Cited by 3 - Related articles - BL Direct - All 3 versions
- ►nih.gov MV Chakravarthy, Y Zhu, MB Wice, T … - Diabetes, 2008 - Am Diabetes Assoc RESULTS—FASDEL mice did not manifest catch-up growth or insulin resistance.
β-Cell mass and insulin secretion were strikingly increased in young FASDEL
mice, but β-cell failure and diabetes occurred with age. FASDEL β-cells ... Cited by 2 - Related articles - All 4 versions
