- ►endojournals.org I Cozar-Castellano, N Fiaschi-Taesch, TA … - Endocrine reviews, 2006 - Endocrine Soc Type 1 and type 2 diabetes both result from inadequate production of insulin by
the ß-cells of the pancreatic islet. Accordingly, strategies that lead to
increased pancreatic ß-cell mass, as well as retained or enhanced function ... Cited by 54 - Related articles - BL Direct - All 5 versions
- ►cell.com P Akpinar, S Kuwajima, J Krützfeldt, M Stoffel - Cell Metabolism, 2005 - Elsevier The signals and molecular mechanisms that regulate the replication of terminally
differentiated β cells are unknown. Here, we report the identification and
characterization of transmembrane protein 27 (Tmem27, collectrin) in ... Cited by 38 - Related articles - All 12 versions
- ►endocrinology-journals.org AM Ackermann, M Gannon - Journal of molecular endocrinology, 2007 - Soc Endocrinology Pancreatic ß-cells are responsible for producing all of the insulin required by
an organism to maintain glucose homeostasis. Defects in development,
maintenance, or expansion of ß-cell mass can result in impaired glucose ... Cited by 35 - Related articles - All 4 versions
- ►endojournals.org PM Vuguin, MH Kedees, L Cui, Y Guz, RW … - Endocrinology, 2006 - Endocrine Soc Although glucagon (GLU) plays a pivotal role in glucose homeostasis, its role in
the regulation of fetal growth and maturation is poorly understood. These issues
were examined in a line of mice with a global deletion of the GLU receptor ... Cited by 14 - Related articles - BL Direct - All 4 versions
EM Duerr, DC Chung - Best Practice & Research Clinical Endocrinology & …, 2007 - Elsevier Neuroendocrine tumors can develop either sporadically or in association with
familial syndromes such as multiple endocrine neoplasia type 1 (MEN1), multiple
endocrine neoplasia type 2 (MEN2) or von Hippel–Lindau (VHL). A variety ... Cited by 13 - Related articles - All 8 versions
- ►diabetesjournals.org RC Vasavada, I Cozar-Castellano, D Sipula, … - Diabetes, 2007 - Am Diabetes Assoc Animal studies show that G 1/S regulatory molecules (D-cyclins, cdk-4, p18, p21,
p27) are critical for normal regulation of β-cell proliferation, mass, and
function. The retinoblastoma protein, pRb, is positioned at the very end of ... Cited by 12 - Related articles - BL Direct - All 5 versions
KJ Chang-Chen, R Mullur, E Bernal-Mizrachi - Reviews in Endocrine & Metabolic Disorders, 2008 - Springer Abstract Type 2 diabetes mellitus is a complex disease characterized by b-cell
failure in the setting of insulin resistance. In early stages of the disease,
pancreatic b-cells adapt to insulin resistance by increasing mass and ... Cited by 11 - Related articles - All 2 versions
S Schinner, F Ülgen, C Papewalis, M Schott, … - Diabetologia, 2008 - Springer Abstract Aims/hypothesis Adipocytes secrete signalling molecules that elicit
responses from target cells, including pancreatic beta cells. Wnt signalling
molecules have recently been identified as novel adipocyte-derived factors. ... Cited by 7 - Related articles - BL Direct - All 2 versions
- ►endocrinology-journals.org R Yu, M Cruz-Soto, SL Calzi, H Hui, S … - Journal of Endocrinology, 2006 - Soc Endocrinology Human pituitary tumor-transforming gene 1 (PTTG1) encodes a securin protein
critically important in regulating chromosome separation. Murine PTTG (mPTTG) is
66% homologous to human PTTG1 and PTTG-null (PTTG–/–) mice exhibit ... Cited by 5 - Related articles - BL Direct - All 3 versions
- ►endojournals.org N Luo, SM Liu, H Liu, Q Li, Q Xu, X Sun, B … - Endocrinology, 2006 - Endocrine Soc Leptin signaling is a critical component of normal insulin sensitivity. Overt
hyperglycemia and type 2 diabetes mellitus can be manifested in states of leptin
signaling deficiencies by the additional effects of other genetic factors. ... Cited by 5 - Related articles - All 4 versions
