- ►nih.gov V Lyssenko, L Groop - Journal of Clinical Investigation, 2007 - Am Soc Clin Investig Genetic variants in the gene encoding for transcription factor-7–like 2
(TCF7L2) have been associated with type 2 diabetes (T2D) and impaired β cell
function, but the mechanisms have remained unknown. We therefore studied ... Cited by 131 - Related articles - BL Direct - All 13 versions
- ►endojournals.org BL Wajchenberg - Endocrine reviews, 2007 - Endocrine Soc There is a progressive deterioration in ß-cell function and mass in type 2
diabetics. It was found that islet function was about 50% of normal at the time
of diagnosis, and a reduction in ß-cell mass of about 60% was shown at ... Cited by 100 - Related articles - BL Direct - All 7 versions
- ►uio.no [PDF] K Ohtsubo, S Takamatsu, MT Minowa, A … - Cell, 2005 - Elsevier Pancreatic β cell-surface expression of glucose transporter 2 (Glut-2) is
essential for glucose-stimulated insulin secretion, thereby controlling blood
glucose homeostasis in response to dietary intake. We show that the murine ... Cited by 68 - Related articles - All 18 versions
- ►endojournals.org V Poitout, RP Robertson - Endocrine reviews, 2008 - Endocrine Soc Glucotoxicity, lipotoxicity, and glucolipotoxicity are secondary phenomena that
are proposed to play a role in all forms of type 2 diabetes. The underlying
concept is that once the primary pathogenesis of diabetes is established, ... Cited by 69 - Related articles - BL Direct - All 7 versions
- ►cell.com H Freeman, K Shimomura, E Horner, RD Cox, … - Cell Metabolism, 2006 - Elsevier The C57BL/6J mouse displays glucose intolerance and reduced insulin secretion.
QTL mapping identified Nicotinamide Nucleotide Transhydrogenase (Nnt), a
nuclear-encoded mitochondrial protein thought to be involved in free ... Cited by 63 - Related articles - All 13 versions
- ►shouxi.net CG Ostenson, H Gaisano, L Sheu, A Tibell, T … - Diabetes, 2006 - Am Diabetes Assoc Exocytosis of insulin is dependent on the soluble N-ethylmaleimide attachment
protein receptor (SNARE) complex proteins in the B-cells. We assessed insulin
release as well as gene and protein expression of SNARE complex protein in ... Cited by 49 - Related articles - BL Direct - All 5 versions
P Marchetti, M Bugliani, R Lupi, L Marselli, M … - Diabetologia, 2007 - Springer Page 1. ARTICLE The endoplasmic reticulum in pancreatic beta cells of type 2 diabetes
patients P. Marchetti & M. Bugliani & R. Lupi & L. Marselli & ... Cited by 47 - Related articles - BL Direct - All 2 versions
- ►diabetesjournals.org N Welsh, M Cnop, I Kharroubi, M Bugliani, R … - Diabetes, 2005 - Am Diabetes Assoc Different degrees of β-cell failure and apoptosis are present in type 1 and
type 2 diabetes. It has been recently suggested that high glucose–induced
β-cell apoptosis in type 2 diabetes shares a final common pathway with ... Cited by 40 - Related articles - BL Direct - All 6 versions
FM Ashcroft - Biochemical Society Transactions, 2006 - biochemsoctrans.cn Abstract This review summarizes advances in our understanding of the structure
and function of the ATP-sensitive potassium (KATP) channel of the pancreatic
β-cell that have been made over the last 5 years. It discusses recent ... Cited by 30 - Related articles - View as HTML - BL Direct - All 7 versions
- ►shouxi.net C Kjørholt, MC Åkerfeldt, TJ Biden, DR … - Diabetes, 2005 - Am Diabetes Assoc The β-cell is a highly specialized cell with a unique differentiation that
optimizes glucose-induced insulin secretion (GIIS). Here, we evaluated changes
in gene expression that accompany β-cell dysfunction in the db/db mouse ... Cited by 27 - Related articles - BL Direct - All 6 versions
