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Scholar Results 1 - 10 of about 33 citing MacDonald: Regulated exocytosis and kiss-and-run of synaptic-like microvesicles in INS-1.... (0.10 sec) 

PKA-dependent and PKA-independent pathways for cAMP-regulated exocytosis

- physiology.org
S Seino, T Shibasaki - Physiological reviews, 2005 - Am Physiological Soc
Stimulus-secretion coupling is an essential process in secretory cells in which
regulated exocytosis occurs, including neuronal, neuroendocrine, endocrine, and
exocrine cells. While an increase in intracellular Ca 2+ concentration ([Ca ...
Cited by 145 - Related articles - BL Direct - All 4 versions

{alpha}-Cells of the endocrine pancreas: 35 years of research but the enigma remains

- endojournals.org
J Gromada, I Franklin, CB Wollheim - Endocrine reviews, 2007 - Endocrine Soc
Glucagon, a hormone secreted from the -cells of the endocrine pancreas, is
critical for blood glucose homeostasis. It is the major counterpart to insulin
and is released during hypoglycemia to induce hepatic glucose output. The ...
Cited by 60 - Related articles - BL Direct - All 4 versions

Selective nucleotide-release from dense-core granules in insulin-secreting cells

- biologists.org
S Obermuller, A Lindqvist, J Karanauskaite, … - Journal of Cell Science, 2005 - jcs.biologists.org
Secretory granules of insulin-secreting cells are used to store and release
peptide hormones as well as low-molecular-weight compounds such as nucleotides.
Here we have compared the rate of exocytosis with the time courses of ...
Cited by 30 - Related articles - BL Direct - All 4 versions

Myosin 5a controls insulin granule recruitment during late-phase secretion


R Ivarsson, X Jing, L Waselle, R Regazzi, E … - Traffic, 2005 - interscience.wiley.com
We have examined the importance of the actin-based molecular motor myosin 5a for
insulin granule transport and insulin secretion. Expression of myosin 5a was
downregulated in clonal INS-1E cells using RNAinterference. Stimulated ...
Cited by 26 - Related articles - BL Direct - All 3 versions

Glucotoxicity inhibits late steps of insulin exocytosis

- endojournals.org
M Dubois, P Vacher, B Roger, D Huyghe, B … - Endocrinology, 2007 - Endocrine Soc
Prolonged exposure of ß-cells to high glucose (glucotoxicity) diminishes
insulin secretion in response to glucose and has been linked to altered
generation of metabolism-secretion coupling factors. We have investigated ...
Cited by 23 - Related articles - BL Direct - All 3 versions

Corelease and differential exit via the fusion pore of GABA, serotonin, and ATP from LDCV in …

- rupress.org
M Braun, A Wendt, J Karanauskaite, J … - Journal of General Physiology, 2007 - jgp.rupress.org
The release of -aminobutyric acid (GABA) and ATP from rat ß cells was monitored
using an electrophysiological assay based on overexpression GABA A or P 2 X 2
receptor ion channels. Exocytosis of LDCVs, detected by carbon fiber ...
Cited by 15 - Related articles - BL Direct - All 8 versions

Two cAMP-dependent pathways differentially regulate exocytosis of large dense-core and …

- nih.gov
H Hatakeyama, N Takahashi, T Kishimoto, T … - The Journal of Physiology, 2007 - Physiological Soc
It has been reported that cAMP regulates Ca 2 + -dependent exocytosis via
protein kinase A (PKA) and exchange proteins directly activated by cAMP (Epac)
in neurons and secretory cells. It has, however, never been clarified how ...
Cited by 15 - Related articles - BL Direct - All 9 versions

The ins and outs of secretion from pancreatic beta-cells: control of single-vesicle exo-and …


PE MacDonald, P Rorsman - Physiology (Bethesda, Md.), 2007 - ncbi.nlm.nih.gov
Exocytosis of insulin-containing secretory vesicles in pancreatic beta-cells is
crucial to maintenance of plasma glucose levels. They fuse with the plasma
membrane in a regulated manner to release their contents and are ...
Cited by 13 - Related articles - BL Direct - All 4 versions

Mechanisms of peptide hormone secretion

- cell.com
DJ Michael, H Cai, W Xiong, J Ouyang, RH … - Trends in Endocrinology & Metabolism, 2006 - Elsevier
According to the classical view, peptide hormones are stored in large dense-core
vesicles that release all of their cargo rapidly and completely when they fuse
with and flatten into the plasma membrane. However, recent imaging studies ...
Cited by 13 - Related articles - All 4 versions

Two-photon excitation imaging of exocytosis and endocytosis and determination of their …


H Kasai, T Kishimoto, T Nemoto, H … - Advanced drug delivery reviews, 2006 - Elsevier
Two-photon excitation imaging is the least invasive optical approach to study
living tissues. We have established two-photon extracellular polar-tracer (TEP)
imaging with which it is possible to visualize and quantify all exocytic ...
Cited by 12 - Related articles - All 5 versions


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