- ►nih.gov NK Lee, H Sowa, E Hinoi, M Ferron, JD Ahn, … - Cell, 2007 - Elsevier The regulation of bone remodeling by an adipocyte-derived hormone implies that
bone may exert a feedback control of energy homeostasis. To test this hypothesis
we looked for genes expressed in osteoblasts, encoding signaling molecules ... Cited by 162 - Related articles - All 14 versions
- ►shouxi.net PE Cryer - Diabetes, 2005 - Am Diabetes Assoc Iatrogenic hypoglycemia is a problem for people with diabetes. It causes
recurrent morbidity, and sometimes death, as well as a vicious cycle of
recurrent hypoglycemia, precluding maintenance of euglycemia over a ... Cited by 73 - Related articles - BL Direct - All 7 versions
- ►endojournals.org J Gromada, I Franklin, CB Wollheim - Endocrine reviews, 2007 - Endocrine Soc Glucagon, a hormone secreted from the -cells of the endocrine pancreas, is
critical for blood glucose homeostasis. It is the major counterpart to insulin
and is released during hypoglycemia to induce hepatic glucose output. The ... Cited by 60 - Related articles - BL Direct - All 4 versions
- ►nih.gov N Marty, M Dallaporta, M Foretz, M Emery, D … - Journal of Clinical Investigation, 2005 - Am Soc Clin Investig Ripglut1;glut2 –/– mice have no endogenous glucose transporter type 2
(glut2) gene expression but rescue glucose-regulated insulin secretion. Control
of glucagon plasma levels is, however, abnormal, with fed hyperglucagonemia ... Cited by 38 - Related articles - BL Direct - All 10 versions
- ►diabetesjournals.org NA Sherry, EB Tsai, KC Herold - Diabetes, 2005 - Am Diabetes Assoc Despite extensive and ongoing investigations of the immune mechanisms of
autoimmune diabetes in humans and animal models, there is much less information
about the natural history of insulin secretion before and after the ... Cited by 37 - Related articles - BL Direct - All 6 versions
- ►endojournals.org BE Dunning, JE Gerich - Endocrine reviews, 2007 - Endocrine Soc The hyperglycemic activity of pancreatic extracts was encountered some 80 yr ago
during efforts to optimize methods for the purification of insulin. The
hyperglycemic substance was named "glucagon," and it was subsequently ... Cited by 32 - Related articles - BL Direct - All 5 versions
- ►ucla.edu [PDF] JJ MEIER, A BHUSHAN, PC BUTLER - Pediatric research, 2006 - journals.lww.com Both type 1 and type 2 diabetes are characterized by a marked deficit in
beta-cell mass causing insufficient insulin secretion. Beta-cell replacement
strategies may eventually provide a cure for diabetes. Current therapeutic ... Cited by 32 - Related articles - BL Direct - All 7 versions
- ►jbc.org J Diao, Z Asghar, CB Chan, MB Wheeler - Journal of Biological Chemistry, 2005 - ASBMB The insulin receptor (IR) and its signaling appear to be essential for insulin
secretion from pancreatic -cells. However, much less is known about the role of
the IR in -cells. To assess the role of the IR in glucagon and insulin ... Cited by 31 - Related articles - BL Direct - All 6 versions
- ►escholarship.org JJ Meier, LL Kjems, JD Veldhuis, P Lefèbvre, … - Diabetes, 2006 - Am Diabetes Assoc Type 2 diabetes is characterized by an ∼60% loss of β-cell mass, a marked
defect in postprandial insulin secretion, and a failure to suppress postprandial
glucagon concentrations. It is possible that postprandial hyperglucagonemia ... Cited by 27 - Related articles - BL Direct - All 9 versions
PE MacDonald, YZ De Marinis, R Ramracheya, … - PLoS Biol, 2007 - biology.plosjournals.org Glucagon, secreted from pancreatic islet α cells, stimulates gluconeogenesis
and liver glycogen breakdown. The mechanism regulating glucagon release is
debated, and variously attributed to neuronal control, paracrine control by ... Cited by 25 - Related articles - Cached - All 7 versions
