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Scholar Results 1 - 10 of about 47 citing Ramana: Requirement of aldose reductase for the hyperglycemic activation of protein kinase.... (0.08 sec) 

Mitogenic Responses of Vascular Smooth Muscle Cells to Lipid Peroxidation-derived …


KV Ramana, A Bhatnagar, S Srivastava, UC … - Journal of Biological Chemistry, 2006 - ASBMB
Products of lipid peroxidation such as 4-hydroxy-trans-2-nonenal (HNE) trigger
multiple signaling cascades that variably affect cell growth, differentiation,
and apoptosis. Because glutathiolation is a significant metabolic fate of ...
Cited by 37 - Related articles - BL Direct - All 7 versions

Endotoxin-induced cardiomyopathy and systemic inflammation in mice is prevented by …

- ahajournals.org [PDF] 
KV Ramana, MS Willis, MD White, JW Horton, … - Circulation, 2006 - Am Heart Assoc
Kluwer Health, 351 West Camden Street, Baltimore, MD 21202-2436. Phone:
410-528-4050. Permissions: Permissions & Rights Desk, Lippincott Williams &
Wilkins, a division of Wolters ... Inflammation in Mice Is Prevented by Aldose
Cited by 30 - Related articles - All 11 versions

Redox activation of aldose reductase in the ischemic heart

- jbc.org
K Kaiserova, S Srivastava, JD Hoetker, SO … - Journal of Biological Chemistry, 2006 - ASBMB
Aldose reductase (AR) reduces cytotoxic aldehydes and glutathione conjugates of
aldehydes derived from lipid peroxidation. Its inhibition has been shown to
increase oxidative injury and abolish the late phase of ischemic ...
Cited by 22 - Related articles - BL Direct - All 6 versions

Aldose reductase mediates the lipopolysaccharide-induced release of inflammatory …

- jbc.org
KV Ramana, AA Fadl, R Tammali, A Reddy, … - Journal of Biological Chemistry, 2006 - ASBMB
Abnormal production of inflammatory cytokines and chemokines is a key feature of
bacterial endotoxin, lipopolysaccharide (LPS)-induced inflammation, and
cytotoxicity; however, the mechanisms regulating production of inflammatory ...
Cited by 18 - Related articles - All 7 versions

Contribution of aldose reductase to diabetic hyperproliferation of vascular smooth muscle …

- diabetesjournals.org
S Srivastava, KV Ramana, R Tammali, SK … - Diabetes, 2006 - Am Diabetes Assoc
The objective of this study was to determine whether the polyol pathway enzyme
aldose reductase mediates diabetes abnormalities in vascular smooth muscle cell
(SMC) growth. Aldose reductase inhibitors (tolrestat or sorbinil) or ...
Cited by 18 - Related articles - BL Direct - All 7 versions

Aldose reductase regulates growth factor-induced cyclooxygenase-2 expression and …

- aacrjournals.org
R Tammali, KV Ramana, SS Singhal, S … - Cancer Research, 2006 - AACR
Colon cancer, a complex multistep process involving progressive disruption of
homeostatic mechanisms controlling intestinal epithelial
proliferation/inflammation, differentiation, and programmed cell death, is ...
Cited by 16 - Related articles - BL Direct - All 4 versions

Aldose Reductase-Regulated Tumor Necrosis Factor-{alpha} Production Is Essential for …

- endojournals.org
KV Ramana, R Tammali, A Reddy, A … - Endocrinology, 2007 - Endocrine Soc
Diabetes is associated with increased generation of cytokines and tissue
inflammation, but it is unclear how increased cytokine synthesis is causally
related to the development of diabetic complications. Here, we report that ...
Cited by 13 - Related articles - BL Direct - All 2 versions

Mechanisms linking diabetes mellitus to the development of atherosclerosis: a role for …

- nrc-cnrc.gc.ca [PDF] 
LA Robertson, AJ Kim, GH Werstuck - Canadian journal of physiology and pharmacology, 2006 - article.pubs.nrc-cnrc.gc.ca
Abstract: Recent decades have seen a significant increase in the incidence of
diabetes mellitus. The number of individu- als with diabetes is projected to
reach 300 million by the year 2025. Diabetes is a leading cause of ...
Cited by 10 - Related articles - BL Direct - All 8 versions

Aldose reductase inhibition prevents endotoxin-induced uveitis in rats

- iovs.org
U Yadav, SK Srivastava, KV Ramana - Investigative ophthalmology & visual science, 2007 - ARVO
METHODS. EIU was induced by a subcutaneous injection of 200 µg
lipopolysaccharide (LPS) in male Lewis rats treated with the AR inhibitor,
zopolrestat (25 mg/kg body weight, intraperitoneally) or its carrier. The ...
Cited by 11 - Related articles - BL Direct - All 3 versions

Mediation of aldose reductase in lipopolysaccharide-induced inflammatory signals in …

- nih.gov
KV Ramana, SK Srivastava - Cytokine, 2006 - Elsevier
Aldose reductase (AR; AKR1B1) a member of aldo-keto reductase super family, that
we had shown earlier mediates cytotoxic signals induced by high glucose,
cytokines and growth factors, also mediates the inflammatory signals ...
Cited by 9 - Related articles - All 5 versions


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