R Andrew, J Westerbacka, J Wahren, H Yki-Järvinen, … - Diabetes, 2005 - Am Diabetes Assoc Cortisol is regenerated from cortisone by 11β-hydroxysteroid dehydrogenase type 1
(11HSD1), amplifying glucocorticoid action in adipose tissue and liver. 11HSD1 inhibitors are
being developed for type 2 diabetes and may be most effective in obesity, where adipose ... Cited by 55 - Related articles - All 6 versions
R Desbriere, V Vuaroqueaux, V Achard, S Boullu- … - Obesity, 2006 - nature.com Objective: Data from rodents provide evidence for a causal role of 11 -hydroxysteroid dehydrogenase
type 1 (11 -HSD-1) in the development of obesity and its complications. In humans, 11
-HSD-1 is increased in subcutaneous adipose tissue (SAT) of obese patients, and higher ... Cited by 34 - Related articles - All 3 versions
EA Francischetti, VA Genelhu - International journal of clinical practice, 2007 - wolfdesign.it Hypertension is an important public health problem in different regions of the world because
of its high prevalence and concomitant risks of cardiovascular and renal diseases(1). A recent
analysis of worldwide data from different regions estimated that the total number of adults ... Cited by 33 - Related articles - View as HTML - BL Direct - All 7 versions
BR Walker - Diabetic medicine, 2006 - pt.wkhealth.com Similarities between the metabolic syndrome and Cushing's syndrome, and reversibility of the
features of Cushing's syndrome, suggest that cortisol may contribute to the pathophysiology of
both conditions and that reducing cortisol action may provide a novel therapeutic ... Cited by 28 - Related articles - BL Direct - All 6 versions
BR Walker, R Andrew - Ann NY Acad Sci, 2006 - interscience.wiley.com Abstract: Activation of intracellular glucocorticoid receptors is determined not only by the plasma
concentrations of cortisol, under the influence of the hypothalamic-pituitary-adrenal (HPA)
axis, but also by 11HSD enzymes within the target cell which interconvert cortisol with its ... Cited by 32 - Related articles - BL Direct - All 4 versions
- ►endojournals.org [PDF] A Gambineri, V Vicennati, S Genghini, F … - Journal of Clinical …, 2006 - Endocrine Soc Page 1. 1 GENETIC VARIATION IN 11β-HYDROXYSTEROID DEHYDROGENASE
TYPE 1 PREDICTS ADRENAL HYPERANDROGENISM AMONGST LEAN WOMEN
WITH POLYCYSTIC OVARY SYNDROME Alessandra Gambineri ... Cited by 24 - Related articles - BL Direct - All 6 versions
JW Tomlinson, PM Stewart - Nature clinical practice. Endocrinology & …, 2005 - ncbi.nlm.nih.gov The magnitude of the obesity and metabolic syndrome epidemic has heightened the need for
the development of new and effective treatments. Although circulating cortisol concentrations
are not elevated in obesity or in the metabolic syndrome, decreasing the tissue-specific ... Cited by 25 - Related articles - BL Direct - All 3 versions
Z Michailidou, MD Jensen, DA Dumesic, KE Chapman, … - Obesity, 2007 - nature.com Objectives: In ideopathic obesity, there is evidence that enhanced cortisol regeneration within
abdominal subcutaneous adipose tissue may contribute to adiposity and metabolic disease.
Whether the cortisol regenerating enzyme, 11 -hydroxysteroid dehydrogenase type 1 (11 ... Cited by 22 - Related articles - All 3 versions
- ►endojournals.org DJ Wake, NZM Homer, R Andrew, BR … - Journal of Clinical …, 2006 - Endocrine Soc Context: Extraadrenal regeneration of cortisol by 11ß-hydroxysteroid dehydrogenase type 1
(11HSD1) is increased after a mixed meal. It is unknown which tissue is responsible and whether
this reflects the complex transcriptional control of 11HSD1 or posttranscriptional control ... Cited by 20 - Related articles - BL Direct - All 6 versions
SK Paulsen, SB Pedersen, S Fisker, B Richelsen - Obesity, 2007 - nature.com Objective: Pre-receptor amplification of glucocorticoids is, in part, determined by the isoenzymes
11 -hydroxysteroid dehydrogenase (11 -HSD) type 1 and type 2, interconverting inert cortisone
and active cortisol. Increased tissue activity of cortisol may play a part in features of the ... Cited by 19 - Related articles - All 2 versions
