- ►nih.gov VEH Carlton, X Hu, AP Chokkalingam, SJ … - The American Journal of Human Genetics, 2005 - Elsevier The minor allele of the R620W missense single-nucleotide polymorphism (SNP)
(rs2476601) in the hematopoietic-specific protein tyrosine phosphatase gene,
PTPN22, has been associated with multiple autoimmune diseases, including ... Cited by 108 - Related articles - BL Direct - All 15 versions
- ►oxfordjournals.org YH Lee, YH Rho, SJ Choi, JD Ji, GG Song, SK … - Rheumatology, 2007 - Br Soc Rheumatology Objective. To assess whether combined evidence shows the association between the
protein tyrosine phosphatase non-receptor 22 (PTPN22) C1858T polymorphism and
autoimmune diseases, and to summarize the effect size of the polymorphism ... Cited by 99 - Related articles - BL Direct - All 5 versions
PK Gregersen, HS Lee, F Batliwalla, AB … - Seminars in Immunology, 2006 - Elsevier The 620W allelic variant of the intracellular tyrosine phosphatase, PTPN22, is
associated with a number of different autoimmune disorders, and this provides
direct evidence for common mechanisms underlying many of these diseases. ... Cited by 92 - Related articles - All 2 versions
N Bottini, T Vang, F Cucca, T Mustelin - Seminars in immunology, 2006 - Elsevier We recently discovered that a single-nucleotide polymorphism (SNP) in the
lymphoid tyrosine phosphatase (LYP), encoded by the PTPN22 gene on chromosome
1p13, correlates strongly with the incidence of type 1 diabetes (T1D) in ... Cited by 88 - Related articles - All 3 versions
E Kawasaki, T Awata, H Ikegami, T Kobayashi … - American journal of medical genetics. Part A, 2006 - interscience.wiley.com It is also possible that your web browser is not configured or not able to
display style sheets. In this case, although the visual presentation will be
degraded, the site should continue to be functional. We recommend using the ... Cited by 47 - Related articles - BL Direct - All 3 versions
LM Gomez, JM Anaya, CI Gonzalez, R Pineda- … - Genes and Immunity, 2005 - nature.com A functional single nucleotide polymorphism (SNP) C1858T in the protein tyrosine
phosphatase nonreceptor 22 (PTPN22) gene encoding an intracellular phosphatase
with negative regulatory effects on T-cell activation is associated with ... Cited by 43 - Related articles - BL Direct - All 3 versions
MJ Haller, MA Atkinson, D Schatz - The Pediatric Clinics of North America, 2005 - Elsevier Type 1 diabetes mellitus (T1D) is a heterogeneous disorder characterized by
autoimmune-mediated destruction of pancreatic beta cells that culminates in
absolute insulin deficiency. T1D is most commonly diagnosed in children and ... Cited by 35 - Related articles - All 17 versions
T Vang, AV Miletic, N Bottini, T Mustelin - Autoimmunity, 2007 - informahealthcare.com The discovery that a single-nucleotide polymorphism (SNP) in lymphoid tyrosine
phosphatase (LYP), encoded by the PTPN22 gene, is associated with type 1
diabetes (T1D) has now been verified by numerous studies and has been ... Cited by 34 - Related articles - BL Direct - All 4 versions
MF Seldin, R Shigeta, K Laiho, H Li, H Saila … - Genes and Immunity, 2005 - nature.com Several studies have identified the PTPN22 allelic variant 1858 C/T that encodes
the R620W amino-acid change as a putative susceptibility factor in autoimmune
diseases. The current study was undertaken to examine a large cohort of ... Cited by 33 - Related articles - BL Direct - All 4 versions
- ►oxfordjournals.org A Hinks, J Worthington, W Thomson - Rheumatology, 2006 - Br Soc Rheumatology Despite the wealth of evidence to support the involvement of multiple genetic
factors in rheumatoid arthritis (RA), since the identification of the link
between RA and HLA class II genes over 30 yr ago no single convincing ... Cited by 32 - Related articles - BL Direct - All 5 versions
