S Bonner-Weir, GC Weir - Nature biotechnology, 2005 - nature.com Two major initiatives are under way to correct the -cell deficit of diabetes:
one would generate -cells ex vivo that are suitable for transplantation, and the
second would stimulate regeneration of -cells in the pancreas. Studies of ... Cited by 172 - Related articles - All 3 versions
- ►uab.edu [PDF] Q Zhou, J Brown, A Kanarek, J Rajagopal, DA … - Nature, 2008 - nature.com One goal of regenerative medicine is to instructively convert adult cells into
other cell types for tissue repair and regeneration. Although isolated examples
of adult cell reprogramming are known, there is no general understanding of ... Cited by 109 - Related articles - All 25 versions
- ►physoc.org P Newsholme, EP Haber, SM Hirabara, ELO … - The Journal of Physiology, 2007 - Physiological Soc It is now widely accepted, given the current weight of experimental evidence,
that reactive oxygen species (ROS) contribute to cell and tissue dysfunction and
damage caused by glucolipotoxicity in diabetes. The source of ROS in the ... Cited by 59 - Related articles - BL Direct - All 8 versions
- ►biologists.org LC Murtaugh - Development, 2007 - dev.biologists.org The development of insulin-producing pancreatic beta (ß)-cells represents the
culmination of a complex developmental program. Cells of the posterior foregut
assume a pancreatic identity, cells within the expanding pancreatic ... Cited by 54 - Related articles - BL Direct - All 5 versions
DQ Tang, S Lu, YP Sun, E Rodrigues, W Chou … - Laboratory Investigation, 2006 - pathology.ufl.edu Adenovirus-mediated transient expression of the pancreatic duodenal homeobox
transcription factor Pdx1 in mouse liver activates pancreatic endocrine and
exocrine genes, the latter reportedly resulting in severe hepatitis. ... Cited by 26 - Related articles - View as HTML - BL Direct - All 6 versions
SL Samson, L Chan - Trends in Endocrinology & Metabolism, 2006 - Elsevier A cure for type 1 (insulin dependent) diabetes might be found in generating
surrogate insulin-producing cells to replace β cells. A gene therapy strategy
using constructs designed to allow glucose-regulated insulin transcription ... Cited by 25 - Related articles - All 3 versions
H Kaneto, T Matsuoka, N Katakami, D … - Current Molecular Medicine, 2007 - ingentaconnect.com Department of Internal Medicine and Therapeutics, Osaka University Graduate
School of Medicine, 2-2 Ya- madaoka, Suita, Osaka 565-0871, Japan Abstract:
Failure of pancreatic -cells is the common characteristic of type 1 and ... Cited by 21 - Related articles - BL Direct - All 2 versions
- ►nih.gov DA Babu, TG Deering, RG Mirmira - Molecular genetics and metabolism, 2007 - Elsevier Emerging evidence over the past decade indicates a central role for
transcription factors in the embryonic development of pancreatic islets and the
consequent maintenance of normal glucose homeostasis. Pancreatic and ... Cited by 17 - Related articles - All 3 versions
- ►weizmann.ac.il [PDF] K Shternhall-Ron, FJ Quintana, S Perl, I … - Journal of Autoimmunity, 2007 - Elsevier Our data demonstrate that 43% of the overtly diabetic CAD-NOD mice treated with
Ad-CMV-PDX-1 became normoglycemic and maintained a stable body weight. Ectopic
PDX-1 expression induced pancreatic gene expression and insulin production ... Cited by 16 - Related articles - All 7 versions
- ►ufl.edu [PDF] LJ Yang - Autoimmunity Reviews, 2006 - Elsevier Consistent with the common embryonic origin of liver and pancreas as well the
similar glucose-sensing systems in hepatocytes and pancreatic β-cells, it
should not be surprising that liver stem cells/hepatocytes can ... Cited by 14 - Related articles - All 4 versions
