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Scholar Results 1 - 10 of about 82 citing Kershaw: Adipocyte-specific glucocorticoid inactivation protects against diet-induced obesity. (0.19 sec) 

[PDF] The human obesity gene map: the 2005 update


T Rankinen, A Zuberi, YC Chagnon, SJ Weisnagel, G … - Obesity, 2006 - pbrc.edu
Abstract RANKINEN, TUOMO, AAMIR ZUBERI, YVON C. CHAGNON, S. JOHN
WEISNAGEL, GEORGE ARGYROPOULOS, BRANDON WALTS, LOUIS PE´RUSSE, AND CLAUDE
BOUCHARD. The human obesity gene map: the 2005 update. Obesity. 2006;14: ...
Cited by 335 - Related articles - View as HTML - All 6 versions

[PDF] Approaching the shared biology of obesity and depression: the stress axis as the …


SR Bornstein, A Schuppenies, ML Wong, J … - Molecular psychiatry, 2006 - manpixforfit.59.to
Obesity and depression are serious public health problems and also constitute cardiovascular
disease risk factors. Research organizations have called for efforts to explore the interrelationship
between obesity and depression. A useful starting point is the fact that in both disorders ...
Cited by 33 - Related articles - View as HTML - BL Direct - All 8 versions

Adipose tissue as source and target for novel therapies

- adipo-site.net [PDF] 
J Klein, N Perwitz, D Kraus, M Fasshauer - Trends in Endocrinology & …, 2006 - Elsevier
The physiology of adipose tissue has a key role in the pathogenesis of the metabolic syndrome
and related cardiovascular disorders. Three main functions of adipocytes have been proposed
to explain this role: the secretion of adipocyte-derived hormones (so-called adipokines), ...
Cited by 33 - Related articles - All 11 versions

Sphingolipids, insulin resistance, and metabolic disease: new insights from in vivo …

- endojournals.org
WL Holland, SA Summers - Endocrine Reviews, 2008 - Endocrine Soc
Obesity and dyslipidemia are risk factors for metabolic disorders including diabetes and cardiovascular
disease. Sphingolipids such as ceramide and glucosylceramides, while being a relatively minor
component of the lipid milieu in most tissues, may be among the most pathogenic lipids in ...
Cited by 30 - Related articles - All 7 versions

Pivotal role of the mineralocorticoid receptor in corticosteroid-induced …

- fasebj.org
M Caprio, B Feve, A Claes, S Viengchareun, M Lombes … - The FASEB Journal, 2007 - FASEB
In addition to their role in controlling water and salt homeostasis, recent work suggests that aldosterone
and mineralocorticoid receptors (MR) may be involved in adipocyte biology. This is of particular
relevance given the role of MR as a high-affinity receptor for both mineralocorticoids and ...
Cited by 29 - Related articles - BL Direct - All 4 versions

11β-HSD Type 1 Expression in Human Adipose Tissue: Impact of Gender, Obesity, …


SK Paulsen, SB Pedersen, S Fisker, B Richelsen - Obesity, 2007 - nature.com
Objective: Pre-receptor amplification of glucocorticoids is, in part, determined by the isoenzymes
11 -hydroxysteroid dehydrogenase (11 -HSD) type 1 and type 2, interconverting inert cortisone
and active cortisol. Increased tissue activity of cortisol may play a part in features of the ...
Cited by 19 - Related articles - All 2 versions

Inhibition of 11 {beta}-Hydroxysteroid Dehydrogenase Type 1 Activity in Vivo Limits …

- endojournals.org
JW Tomlinson, M Sherlock, B Hughes, SV … - Journal of Clinical …, 2007 - Endocrine Soc
Context: The pathophysiological importance of glucocorticoids (GCs) is exemplified by patients
with Cushing's syndrome who develop hypertension, obesity, and insulin resistance. At a cellular
level, availability of GCs to the glucocorticoid and mineralocorticoid receptors is ...
Cited by 18 - Related articles - BL Direct - All 2 versions

Glucocorticoids produce whole body insulin resistance with changes in cardiac …

- physiology.org
D Qi, B Rodrigues - American Journal of Physiology- …, 2007 - Am Physiological Soc
Insulin resistance is viewed as an insufficiency in insulin action, with glucocorticoids being recognized
to play a key role in its pathogenesis. With insulin resistance, metabolism in multiple organ systems
such as skeletal muscle, liver, and adipose tissue is altered. These metabolic alterations ...
Cited by 20 - Related articles - BL Direct - All 5 versions

Glucocorticoid metabolism within superficial subcutaneous rather than visceral …


JH Goedecke, DJ Wake, NS Levitt, EV … - CLINICAL …, 2006 - interscience.wiley.com
Objective Glucocorticoid hyperactivity in adipose tissue, due to up-regulation of local glucocorticoid
reactivation by 11β-hydroxysteroid dehydrogenase-1 (11HSD1) or of glucocorticoid receptors
(GR), may underpin susceptibility to the metabolic syndrome. This hypothesis has been ...
Cited by 16 - Related articles - BL Direct - All 5 versions

Readjusting the Glucocorticoid Balance: An Opportunity for Modulators of 11- …


AG Atanasov, A Odermatt - … &# 38; Immune Disorders-Drug Targets …, 2007 - ingentaconnect.com
Abstract: Glucocorticoids play a pivotal role in the regulation of most essential physiological
processes, including energy metabolism, maintenance of electrolyte balance and blood
pressure, immune-modulation and stress responses, cell prolif- eration and ...
Cited by 17 - Related articles - BL Direct - All 2 versions


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