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Scholar Results 1 - 10 of about 29 citing Stalker: The calcium-dependent protease calpain causes endothelial dysfunction in type 2 diabetes. (0.08 sec) 

Protein kinase A-dependent translocation of Hsp90 {alpha} impairs endothelial nitric-oxide …

- jbc.org
H Lei, A Venkatakrishnan, S Yu, A Kazlauskas - Journal of Biological Chemistry, 2007 - ASBMB
Diabetes mellitus (DM) and high glucose (HG) are known to reduce the
bioavailability of nitric oxide (NO) by modulating endothelial nitric-oxide
synthase (eNOS) activity. eNOS is regulated by several mechanisms including ...
Cited by 16 - Related articles - All 5 versions

Homocysteine-mediated activation and mitochondrial translocation of calpain regulates …

- physiology.org
KS Moshal, M Singh, U Sen, DSE Rosenberger … - American Journal of Physiology- Heart and Circulatory …, 2006 - Am Physiological Soc
Hyperhomocysteinemia (HHcy) is associated with atherosclerosis, stroke, and
dementia. Hcy causes extracellular matrix remodeling by the activation of matrix
metalloproteinase-9 (MMP-9), in part, by inducing redox signaling and ...
Cited by 13 - Related articles - BL Direct - All 3 versions

Hyperglycemia Is a Major Determinant of Albumin Permeability in Diabetic Microcirculation

- diabetesjournals.org
R Scalia, Y Gong, B Berzins, LJ Zhao, K … - Diabetes, 2007 - Am Diabetes Assoc
Increased permeability to albumin is a well-known feature of diabetic
microvasculature and a negative prognostic factor of vascular complications. The
mechanisms responsible for loss of the physiological albumin barrier in ...
Cited by 11 - Related articles - BL Direct - All 5 versions

Proteolytic degradation of nitric oxide synthase isoforms by calpain is modulated by the …


M Averna, R Stifanese, R De Tullio, F … - FEBS journal, 2007 - interscience.wiley.com
Ca 2+ loading of Jurkat and bovine aorta endothelium cells induces the
degradation of the neuronal and endothelial nitric oxide synthases that are
selectively expressed in these cell lines. For neuronal nitric oxide ...
Cited by 9 - Related articles - BL Direct - All 4 versions

Calpains and their multiple roles in diabetes mellitus


F Harris, S Biswas, J Singh, S Dennison, DA … - ANNALS-NEW YORK ACADEMY OF SCIENCES, 2006 - interscience.wiley.com
Abstract: Type 2 diabetes mellitus (T2DM) can lead to death without treatment
and it has been predicted that the condition will affect 215 million people
worldwide by 2010. T2DM is a multifactorial disorder whose precise genetic ...
Cited by 7 - Related articles - BL Direct - All 5 versions

High glucose initiates calpain-induced necrosis before apoptosis in LLC-PK1 cells


SM Harwood, DA Allen, MJ Raftery, MM … - Kidney international, 2007 - nature.com
Cells exposed to high ambient glucose concentrations are subject to increases in
intracellular calcium ([Ca 2+ ] i ). We therefore considered it likely that the
calcium-dependent cysteine protease calpain would play a role in the ...
Cited by 6 - Related articles - BL Direct - All 3 versions

Atrial natriuretic peptide attenuates elevations in Ca2+ and protects hepatocytes by …

- jbc.org
AK Green, RC Stratton, PE Squires, AWM … - Journal of Biological Chemistry, 2007 - ASBMB
Elevations in intracellular Ca 2+ concentration and calpain activity are common
early events in cellular injury, including that of hepatocytes. Atrial
natriuretic peptide is a circulating hormone that has been shown to be ...
Cited by 5 - Related articles - All 5 versions

Erectile dysfunction and diabetes mellitus: mechanistic considerations from studies in …


NE Cameron, MA Cotter - Current Diabetes Reviews, 2007 - ingentaconnect.com
University of Aberdeen, Aberdeen, Scotland, UK Abstract: Diabetes is a major
risk factor for erectile dysfunction. The condition degrades both neural and
vascular endothelium penile control systems. Experimental and ...
Cited by 7 - Related articles - BL Direct - All 2 versions

In vivo degradation of nitric oxide synthase (NOS) and heat shock protein 90 (HSP90) by …


M Averna, R Stifanese, R De Tullio, F … - FEBS JOURNAL, 2008 - interscience.wiley.com
We have shown previously that isolated heat shock protein 90 (HSP90) and nitric
oxide synthase (NOS), once associated in a heterocomplex, become completely
resistant to calpain digestion. In this study, it is shown that, in vivo, ...
Cited by 4 - Related articles - BL Direct - All 2 versions

Endothelial S100A1 modulates vascular function via nitric oxide

- ahajournals.org [PDF] 
ST Pleger, DM Harris, C Shan, LE Vinge, JK … - Circulation Research, 2008 - Am Heart Assoc
Abstract—S100A1, a Ca2-binding protein of the EF-hand type, is known to
modulate sarcoplasmic reticulum Ca2 handling in skeletal muscle and
cardiomyocytes. Recently, S100A1 has been shown to be expressed in ...
Cited by 4 - Related articles - All 5 versions


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