LL Bonnycastle, CJ Willer, KN Conneely, AU Jackson, … - Diabetes, 2006 - Am Diabetes Assoc Prior reports have suggested that variants in the genes for maturity-onset diabetes of the young
(MODY) may confer susceptibility to type 2 diabetes, but results have been conflicting and coverage
of the MODY genes has been incomplete. To complement our previous studies of HNF4A, ... Cited by 40 - Related articles - BL Direct - All 10 versions
- ►diabetesjournals.org K Hara, M Horikoshi, H Kitazato, C Ito, M Noda, J … - Diabetes, 2006 - Am Diabetes Assoc Hepatocyte nuclear factor (HNF)-4α is a transcription factor known as a key molecule in the development
and functions of the β-cells. In a previously performed genome-wide scan of Japanese type 2
diabetic sibpairs, we observed linkage of type 2 diabetes to chromosome 20q12-q13, a ... Cited by 25 - Related articles - BL Direct - All 5 versions
- ►diabetesjournals.org J Holmkvist, P Almgren, V Lyssenko, CM Lindgren, KF … - Diabetes, 2008 - Am Diabetes Assoc RESULTS—The polymorphism rs1169288 in HNF-1α strongly predicted future type 2 diabetes
(hazard ratio [HR] 1.2, P = 0.0002). Also, SNPs rs4810424 and rs3212198 in HNF-4α nominally
predicted future type 2 diabetes (HR 1.3 [95% CI 1.0–1.6], P = 0.03; and 1.1 [1.0–1.2], P = ... Cited by 18 - Related articles - All 3 versions
- ►tokushima-u.ac.jp [PDF] T Tanahashi, D Osabe, K Nomura, S Shinohara, H Kato … - Human genetics, 2006 - Springer Abstract Several linkage studies have predicted that human chromosome 20q is closely related
to type 2 diabetes, but there is no clear evidence that certain variant(s) or gene(s) have strong
effects on the disease within this region. To examine disease susceptibility variant in ... Cited by 15 - Related articles - BL Direct - All 5 versions
L Andrulionytė, O Laukkanen, JL Chiasson, M … - Journal of Molecular …, 2006 - Springer Page 1. J Mol Med (2006) 84: 701–708 DOI 10.1007/s00109-006-0063-3 ORIGINAL ARTICLE
Laura Andrulionytė . Olli Laukkanen . Jean-Louis Chiasson . Markku Laakso . STOP-NIDDM
Study Group Single nucleotide polymorphisms of the HNF4α gene are ... Cited by 9 - Related articles - All 4 versions
DM Lehman, DK Richardson, CP Jenkinson, KJ Hunt, … - Diabetes, 2007 - Am Diabetes Assoc Common and rare variants of the hepatocyte nuclear factor 4α (HNF4A) gene have been associated
with type 2 diabetes and related traits in several populations suggesting the involvement of this
transcription factor in diabetes pathogenesis. Single nucleotide polymorphisms (SNPs) ... Cited by 12 - Related articles - BL Direct - All 5 versions
L Rahib, NK MacLennan, S Horvath, JC Liao, KM … - European Journal of …, 2007 - nature.com Glycerol kinase (GK) is at the interface of fat and carbohydrate metabolism and has been implicated
in insulin resistance and type 2 diabetes mellitus. To define GK's role in insulin resistance, we
examined gene expression in brown adipose tissue in a glycerol kinase knockout (KO) ... Cited by 9 - Related articles - BL Direct - All 3 versions
RM Watanabe, MH Black, AH Xiang, H Allayee, JM … - Diabetes care, 2007 - Am Diabetes Assoc The successful application of positional cloning, the process of disease susceptibility gene identification
using gene mapping techniques, to identify the gene underlying cystic fibrosis (1) opened the
era of gene hunting. The subsequent identification of susceptibility genes underlying ... Cited by 10 - Related articles - BL Direct - All 7 versions
- ►diabetesjournals.org I Barroso, J Luan, E Wheeler, P Whittaker, J Wasson, E … - Diabetes, 2008 - Am Diabetes Assoc OBJECTIVE—Single nucleotide polymorphisms (SNPs) in the P2 promoter region of HNF4A
were originally shown to be associated with predisposition for type 2 diabetes in Finnish,
Ashkenazi, and, more recently, Scandinavian populations, but they generated conflicting ... Cited by 7 - Related articles - All 8 versions
L Love-Gregory, MA Permutt - Current Opinion in Clinical Nutrition & …, 2007 - journals.lww.com Purpose of review: Variants in the hepatocyte nuclear factor 4α (HNF4A) gene play a role in the
development of diabetes mellitus. Although genetic variation in and around HNF4A regulatory
regions has received considerable attention, the significance of these variants in the ... Cited by 6 - Related articles - BL Direct - All 5 versions
