- ►nas.edu [PDF] JP Mordes, P Poussier, AR Rossini, EP … - Animal Models of … - books.google.com 2 Animal Models of Diabetes BBDR Rats and Translational Modeling Fidelity 19 Immunological
Perturbation and Diabetes Induction in Other Rat Strains 20 TLRLigation 20 Viral Infection 21 A
Working Hypothesis of Autoimmune ... Cited by 43 - Related articles - BL Direct - All 4 versions
N van der Werf, FG Kroese, J Rozing, JL … - Diabetes/Metabolism … - interscience.wiley.com During the last decades, the incidence of type 1 diabetes (T1D) has increased significantly,
reaching percentages of 3% annually worldwide. This increase suggests that besides genetical factors
environmental perturbations ... Cited by 39 - Related articles - BL Direct - All 3 versions
- ►jimmunol.org D Zipris, E Lien, A Nair, JX Xie, DL Greiner, … - The Journal of …, 2007 - Am Assoc Immnol Viral infections are associated epidemiologically with the expression of type 1 diabetes in humans,
but the mechanisms underlying this putative association are unknown. To investigate the role of
viruses in diabetes, we used a ... Cited by 28 - Related articles - BL Direct - All 7 versions
M von Herrath - Diabetes, 2009 - Am Diabetes Assoc We will take a journey from basic pathogenetic mechanisms elicited by viral infections that play a
role in the development of type 1 diabetes to clinical interventions, where we will discuss novel
combination therapies. The role of ... Cited by 8 - Related articles - All 10 versions
JM Fuller, AE Kwitek, TJ Hawkins, DH Moralejo, W Lu, … - Diabetes, 2006 - Am Diabetes Assoc Failure to express the Gimap5 protein is associated with lymphopenia (lyp) and linked to spontaneous
diabetes in the diabetes-prone BioBreeding (BBDP) rat. Gimap5 is a member of seven related genes
located within 150 Kb on rat ... Cited by 6 - Related articles - BL Direct - All 5 versions
E Lien, D Zipris - Current Molecular Medicine, 2009 - ingentaconnect.com 1 Department of Medicine, University of Massachusetts Medical School, Worcester, MA 01655, USA 2
Department of Pediatrics, Barbara Davis Center for Childhood Diabetes, University of Colorado,
Aurora, CO 80045, USA Abstract: ... Cited by 5 - Related articles - All 2 versions
L HORNUM, D LUNDSGAARD, H … - ANNALS-NEW YORK …, 2007 - interscience.wiley.com Abstract : The Iddm4 gene controls diabetes in rats depleted of regulatory T cells (T reg ) and
immune-activated via treatment with the toll-like receptor 3 (TLR-3) ligand, polyI:C. Both
diabetes-resistant (BBDR) and ... Cited by 3 - Related articles - BL Direct - All 4 versions
JP Mordes, L Cort, E Norowski, J Leif, JM Fuller, Å … - Mammalian Genome, 2009 - Springer Abstract Iddm14 (formerly Iddm4) is a non-MHC-linked genetic locus associated with autoimmune
diabetes. Its effects have been well-documented in BB-derived rats in which diabetes is either
induced by immunologic perturba- ... Cited by 4 - Related articles - All 2 versions
- ►diabetesjournals.org RH Wallis, KS Wang, D Dabrowski, L Marandi, T Ning, … - Diabetes, 2007 - Am Diabetes Assoc OBJECTIVE—The biobreeding diabetes-prone (BBDP) rat spontaneously develops type 1 diabetes. Two of
the genetic factors contributing to this syndrome are the major histocompatibility complex (Iddm1)
and a Gimap5 mutation (Iddm2) ... Cited by 2 - Related articles - BL Direct - All 7 versions
JM Fuller, M Bogdani, TD Tupling, RA … - Physiological …, 2009 - Am Physiological Soc Congenic DRF. f/f rats are protected from type 1 diabetes (T1D) by 34 Mb of F344 DNA introgressed
proximal to the gimap5 lymphopenia gene. To dissect the genetic factor(s) that confer protection
from T1D in the DRF. f/f rat line, ... Related articles - All 3 versions
