- ►shouxi.net DML Tsukumo, MA Carvalho-Filho, JBC … - Diabetes, 2007 - Am Diabetes Assoc Obesity is associated with insulin resistance and a state of abnormal
inflammatory response. The Toll-like receptor (TLR)4 has an important role in
inflammation and immunity, and its expression has been reported in most ... Cited by 97 - Related articles - BL Direct - All 7 versions
- ►nih.gov C de Luca, JM Olefsky - FEBS letters, 2008 - Elsevier Obesity-induced chronic inflammation is a key component in the pathogenesis of
insulin resistance and the Metabolic syndrome. In this review, we focus on the
interconnection between obesity, inflammation and insulin resistance. Pro- ... Cited by 70 - Related articles - All 11 versions
- ►nih.gov A Martínez-Ruiz, L Villanueva, CG de Orduña, … - Proceedings of the National Academy of Sciences of …, 2005 - National Acad Sciences Nitric oxide is implicated in a variety of signaling pathways in different
systems, notably in endothelial cells. Some of its effects can be exerted
through covalent modifications of proteins and, among these modifications, ... Cited by 56 - Related articles - All 9 versions
- ►physoc.org P Newsholme, EP Haber, SM Hirabara, ELO … - The Journal of Physiology, 2007 - Physiological Soc It is now widely accepted, given the current weight of experimental evidence,
that reactive oxygen species (ROS) contribute to cell and tissue dysfunction and
damage caused by glucolipotoxicity in diabetes. The source of ROS in the ... Cited by 60 - Related articles - BL Direct - All 8 versions
NR Leslie - Antioxidants & Redox Signaling, 2006 - liebertonline.com INTRODUCTION T HE COMPLEX BEHAVIOR of the cells of higher multicellular
organisms is regulated by multilayered signal transduc- tion pathways and
networks that integrate information from several sources to control a ... Cited by 28 - Related articles - BL Direct - All 5 versions
- ►fasebj.org CT De Souza, EP Araujo, LF Stoppiglia, JR … - The FASEB Journal, 2007 - FASEB Recent characterization of the ability of uncoupling protein 2 (UCP2) to reduce
ATP production and inhibit insulin secretion by pancreatic ß-cells has placed
this mitochondrial protein as a candidate target for therapeutics in ... Cited by 26 - Related articles - BL Direct - All 4 versions
- ►shouxi.net J Park, SS Choe, AH Choi, KH Kim, MJ Yoon, … - Diabetes, 2006 - Am Diabetes Assoc In adipocytes, oxidative stress and chronic inflammation are closely associated
with metabolic disorders, including insulin resistance, obesity, cardiovascular
disease, and type 2 diabetes. However, the molecular mechanisms underlying ... Cited by 20 - Related articles - BL Direct - All 7 versions
M Kaneki, N Shimizu, D Yamada, K Chang - Antioxidants & Redox Signaling, 2007 - liebertonline.com I NSULIN RESISTANCE is a major causative factor for type 2 diabetes, which is a
polygenic disease accounting for >90% of patients with diabetes, and is
associated with in- creased risk of cardiovascular disease. Obesity is ... Cited by 18 - Related articles - BL Direct - All 5 versions
- ►pnas.org P Aguiari, S Leo, B Zavan, V Vindigni, A … - Proceedings of the National Academy of Sciences, 2008 - National Acad Sciences Regeneration of mesenchymal tissues depends on a resident stem cell population,
that in most cases remains elusive in terms of cellular identity and
differentiation signals. We here show that primary cell cultures derived ... Cited by 20 - Related articles - BL Direct - All 10 versions
- ►physoc.org JR Pauli, ER Ropelle, DE Cintra, MA … - The Journal of Physiology, 2008 - Physiological Soc Early evidence demonstrates that exogenous nitric oxide (NO) and the NO produced
by inducible nitric oxide synthase (iNOS) can induce insulin resistance. Here,
we investigated whether this insulin resistance, mediated by S-nitrosation ... Cited by 16 - Related articles - BL Direct - All 6 versions
