- ►endojournals.org E Karaskov, C Scott, L Zhang, T Teodoro, M Ravazzola, … - Endocrinology, 2006 - Endocrine Soc Chronic free fatty acid (FFA) exposure induces pancreatic ß-cell death, which may contribute
to the development of type 2 diabetes. The mechanisms involved in FFA-induced cell death are
not completely understood. Here we have investigated the effect of FFA on endoplasmic ... Cited by 95 - Related articles - BL Direct - All 4 versions
- ►nih.gov E Beurel, RS Jope - Progress in neurobiology, 2006 - Elsevier Few things can be considered to be more important to a cell than its threshold for apoptotic cell
death, which can be modulated up or down, but rarely in both directions, by a single
enzyme. Therefore, it came as quite a surprise to find that one enzyme, glycogen ... Cited by 78 - Related articles - All 4 versions
- ►diabetesjournals.org L Shu, NS Sauter, FT Schulthess, AV Matveyenko, J … - Diabetes, 2008 - Am Diabetes Assoc RESEARCH DESIGN AND METHODS—To investigate the effects of TCFL7L2 depletion, isolated
islets were exposed to TCF7L2 small interfering RNA (siRNA) versus scrambled siRNA, and
β-cell survival and function were examined. For TCF7L2 overexpression, islets were ... Cited by 37 - Related articles - BL Direct - All 4 versions
- ►nih.gov JD Johnson, E Bernal-Mizrachi, EU … - Proceedings of the …, 2006 - National Acad Sciences Insulin is both a hormone regulating energy metabolism and a growth factor. We and others have
shown that physiological doses of insulin initiate complex signals in primary human and mouse
β-cells, but the functional significance of insulin's effects on this cell type remains unclear. ... Cited by 32 - Related articles - BL Direct - All 10 versions
SC Martinez, C Cras-Méneur, E Bernal-Mizrachi, MA … - Diabetes, 2006 - Am Diabetes Assoc Glucose controls islet β-cell mass and function at least in part through the phosphatidylinositol
3-kinase (PI3K)/Akt pathway downstream of insulin signaling. The Foxo proteins, transcription
factors known in other tissues to be negatively regulated by Akt activation, affect ... Cited by 32 - Related articles - BL Direct - All 6 versions
R Mussmann, M Geese, F Harder, S Kegel, U … - Journal of Biological …, 2007 - ASBMB Recent developments indicate that the regeneration of beta cell function and mass in patients
with diabetes is possible. A regenerative approach may represent an alternative treatment option
relative to current diabetes therapies that fail to provide optimal glycemic control. Here we ... Cited by 30 - Related articles - All 7 versions
K Hyoda, T Hosoi, N Horie, Y Okuma, K Ozawa, Y … - … and Biophysical Research …, 2006 - Elsevier Stress signals that impair the function of the endoplasmic reticulum (ER) can lead to an accumulation
of unfolded proteins in the ER causing cell death. Recent studies have indicated that ER stress
contributes to several diseases such as neurodegenerative disorders or diabetes. In the ... Cited by 22 - Related articles - All 5 versions
- ►fasebj.org H Yung, S Korolchuk, AM Tolkovsky, DS Charnock- … - The FASEB Journal, 2007 - FASEB Oxidative stress is central to ischemia-reperfusion injury. The role of the endoplasmic reticulum
(ER) in this process is uncertain. In ER signaling, PERK-Nrf2 and Ire-CHOP are two pathways
that determine cell fate under stress. PERK-Nrf2 up-regulates antioxidant enzyme ... Cited by 18 - Related articles - BL Direct - All 7 versions
SC Martinez, K Tanabe, C Cras-Méneur, NA Abumrad, … - Diabetes, 2008 - Am Diabetes Assoc RESULTS—Increasing fatty acid concentrations (100–400 μmol/l palmitate or oleate) led to early
Jun NH 2 -terminal kinase (JNK) activation that preceded induction of ER stress markers and
apoptosis. Foxo1 activity was increased with fatty acid administration and by ... Cited by 15 - Related articles - BL Direct - All 4 versions
Z Liu, K Tanabe, E Bernal-Mizrachi, MA Permutt - Diabetologia, 2008 - Springer Abstract Aims/hypothesis Glycogen synthase kinase-3 (GSK3) has been implicated in the pathophysiology
of several prevalent diseases, including diabetes. However, despite recent progress in our understanding
of the role of GSK3 in the regulation of glucose metabolism in peripheral tissues, the ... Cited by 12 - Related articles - BL Direct - All 3 versions
