KK Bence, M Delibegovic, B Xue, CZ Gorgun, … - Nature medicine, 2006 - leptinresearch.org Obesity is a major health problem and a risk factor for type 2 diabetes. Leptin,
an adipocyte-secreted hormone, acts on the hypothalamus to inhibit food intake
and increase energy expenditure. Most obese individuals develop ... Cited by 89 - Related articles - View as HTML - BL Direct - All 10 versions
SC Woods - Physiology & behavior, 2005 - Elsevier Energy homeostasis is a complex on-going process that includes maintaining
immediately available as well as stored nutrient levels at optimal levels given
the environment. To accomplish this, the brain receives continuous ... Cited by 47 - Related articles - All 4 versions
SC Woods, TA Lutz, N Geary, W Langhans - Philosophical Transactions of the Royal Society B: …, 2006 - rstb.royalsocietypublishing.org The control of food intake and body weight by the brain relies upon the
detection and integration of signals reflecting energy stores and fluxes, and
their interaction with many different inputs related to food palatability ... Cited by 40 - Related articles - BL Direct - All 9 versions
AM Hennige, T Sartorius, O Tschritter, H … - Diabetologia, 2006 - Springer Page 1. Diabetologia (2006) 49: 1274–1282 DOI 10.1007/s00125-006-0192-9 ARTICLE
AM Hennige . T. Sartorius . O. Tschritter . H. Preissl . A. Fritsche . ... Cited by 33 - Related articles - BL Direct - All 3 versions
RH Lustig - Nature Reviews Endocrinology, 2006 - nature.com Childhood obesity has become epidemic over the past 30 years. The First Law of
Thermodynamics is routinely interpreted to imply that weight gain is secondary
to increased caloric intake and/or decreased energy expenditure, two ... Cited by 33 - Related articles - BL Direct - All 5 versions
CW Hay, K Docherty - Diabetes, 2006 - Am Diabetes Assoc DNA sequences that regulate expression of the insulin gene are located within a
region spanning ∼400 bp that flank the transcription start site. This region,
the insulin promoter, contains a number of cis-acting elements that bind ... Cited by 31 - Related articles - BL Direct - All 9 versions
- ►endojournals.org FCW Wu, A Tajar, SR Pye, AJ Silman, JD Finn, … - Journal of Clinical Endocrinology & Metabolism, 2008 - Endocrine Soc Results: Four predictors were associated with distinct modes of altered
function: 1) age: lower free T (FT; –3.12 pmol/liter·yr, P < 0.001) with
raised LH, suggesting impaired testicular function; 2) obesity: lower total ... Cited by 32 - Related articles - All 7 versions
D Russell-Jones, R Khan - Diabetes Obesity and Metabolism, 2007 - interscience.wiley.com Insulin therapy or intensification of insulin therapy commonly results in weight
gain in both type 1 and type 2 diabetes. This weight gain can be excessive,
adversely affecting cardiovascular risk profile. The spectre of weight gain ... Cited by 30 - Related articles - BL Direct - All 3 versions
SK Das, SC Elbein - Cellscience, 2006 - pubmedcentral.nih.gov Type 2 Diabetes results from a complex physiologic process that includes the
pancreatic beta cells, peripheral glucose uptake in muscle, the secretion of
multiple cytokines and hormone-like molecules from adipocytes, hepatic ... Cited by 25 - Related articles - All 3 versions
P Trayhurn, C Bing - Philosophical Transactions of the Royal Society B: …, 2006 - rstb.royalsocietypublishing.org Interest in the biology of white adipose tissue has risen markedly with the
recent surge in obesity and its associated disorders. The tissue is no longer
viewed simply as a vehicle for lipid storage; instead, it is recognized as ... Cited by 23 - Related articles - BL Direct - All 10 versions
