RJ Shaw, KA Lamia, D Vasquez, SH Koo, N Bardeesy, … - Science, 2005 - sciencemag.org The Peutz-Jegher syndrome tumor-suppressor gene encodes a protein-threonine kinase,
LKB1, which phosphorylates and activates AMPK [adenosine monophosphate (AMP)–activated
protein kinase]. The deletion of LKB1 in the liver of adult mice resulted in a nearly ... Cited by 300 - Related articles - BL Direct - All 17 versions
F Bäckhed, JK Manchester, CF … - Proceedings of the …, 2007 - National Acad Sciences The trillions of microbes that colonize our adult intestines function collectively as a metabolic
organ that communicates with, and complements, our own human metabolic apparatus. Given
the worldwide epidemic in obesity, there is interest in how interactions between human ... Cited by 117 - Related articles - BL Direct - All 10 versions
M Zang, S Xu, KA Maitland-Toolan, A Zuccollo, X Hou, … - Diabetes, 2006 - Am Diabetes Assoc Because polyphenols may have beneficial effects on dyslipidemia, which accelerates atherosclerosis
in diabetes, we examined the effect of polyphenols on hepatocellular AMP-activated protein
kinase (AMPK) activity and lipid levels, as well as hyperlipidemia and atherogenesis in ... Cited by 89 - Related articles - BL Direct - All 5 versions
B Viollet, M Foretz, B Guigas, S Horman, R … - The Journal of …, 2006 - Physiological Soc It is now becoming evident that the liver has an important role in the control of whole body metabolism
of energy nutrients. In this review, we focus on recent findings showing that AMP-activated protein
kinase (AMPK) plays a major role in the control of hepatic metabolism. AMPK integrates ... Cited by 80 - Related articles - BL Direct - All 9 versions
- ►nih.gov R Dentin, F Benhamed, JP Pégorier, F … - Journal of Clinical …, 2005 - Am Soc Clin Investig Dietary polyunsaturated fatty acids (PUFAs) are potent inhibitors of hepatic glycolysis and
lipogenesis. Recently, carbohydrate-responsive element–binding protein (ChREBP) was implicated
in the regulation by glucose of glycolytic and lipogenic genes, including those encoding L- ... Cited by 73 - Related articles - BL Direct - All 13 versions
- ►endojournals.org F Andreelli, M Foretz, C Knauf, PD Cani, C Perrin, MA … - Endocrinology, 2006 - Endocrine Soc The AMP-activated kinase (AMPK) is a serine threonine kinase that functions as a fuel sensor
to regulate energy balance at both cellular and whole-body levels. Here we studied how hepatic
AMPK 2 isoform affects hepatic glucose production and peripheral glucose uptake in vivo. ... Cited by 62 - Related articles - All 3 versions
B Guigas, L Bertrand, N Taleux, M Foretz, N … - Diabetes, 2006 - Am Diabetes Assoc AMP-activated protein kinase (AMPK) controls glucose uptake and glycolysis in muscle. Little
is known about its role in liver glucose uptake, which is controlled by glucokinase. We report
here that 5-aminoimidazole-4-carboxamide-1-β-d-ribofuranoside (AICAR), metformin, ... Cited by 45 - Related articles - BL Direct - All 6 versions
- ►ahajournals.org Y Zhang, TS Lee, EM Kolb, K Sun, X Lu, FM … - … , and vascular biology, 2006 - Am Heart Assoc Methods and Results— By using flow channels with cultured ECs, AMPK Thr172 phosphorylation
was increased with changes of flow rate or pulsatility. The activity of LKB1, the upstream kinase
of AMPK, and the phosphorylation of eNOS at Ser1179 were concomitant with AMPK ... Cited by 46 - Related articles - All 11 versions
- ►aspetjournals.org F Rencurel, M Foretz, MR Kaufmann, D Stroka, R … - Molecular pharmacology, 2006 - ASPET Our previous studies have suggested a role for AMP-activated protein kinase (AMPK) in the induction
of CYP2B6 by phenobarbital (PB) in hepatoma-derived cells (Rencurel et al., 2005 Go ). In this
study, we showed in primary human hepatocytes that: 1) 5'-phosphoribosyl-5- ... Cited by 29 - Related articles - All 6 versions
