- ►diabetesjournals.org BJ Davis, Z Xie, B Viollet, MH Zou - Diabetes, 2006 - Am Diabetes Assoc Metformin, one of most commonly used drugs for the treatment of type 2 diabetes,
improves vascular endothelial functions and reduces cardiovascular events in
patients with type 2 diabetes, although its mechanisms remain unknown. The ... Cited by 93 - Related articles - BL Direct - All 6 versions
- ►nodak.edu [PDF] WS Jobgen, SK Fried, WJ Fu, CJ Meininger, … - The Journal of nutritional biochemistry, 2006 - Elsevier Nitric oxide (NO) is synthesized from l-arginine by NO synthase in virtually all
cell types. Emerging evidence shows that NO regulates the metabolism of glucose,
fatty acids and amino acids in mammals. As an oxidant, pathological levels ... Cited by 71 - Related articles - All 13 versions
H Chen - Pharmacological research, 2006 - Elsevier Type 2 diabetes is rapidly becoming a worldwide epidemic. Obesity and sedentary
lifestyle are the main environmental causes for the development of insulin
resistance and type 2 diabetes. In the past decade, it has been ... Cited by 32 - Related articles - All 4 versions
M Kaneki, N Shimizu, D Yamada, K Chang - Antioxidants & Redox Signaling, 2007 - liebertonline.com I NSULIN RESISTANCE is a major causative factor for type 2 diabetes, which is a
polygenic disease accounting for >90% of patients with diabetes, and is
associated with in- creased risk of cardiovascular disease. Obesity is ... Cited by 18 - Related articles - BL Direct - All 5 versions
- ►nursing2007.com JAJ Martyn, M Kaneki, S Yasuhara - Anesthesiology, 2008 - journals.lww.com Obesity is a major cause of type 2 diabetes, clinically evidenced as
hyperglycemia. The altered glucose homeostasis is caused by faulty signal
transduction via the insulin signaling proteins, which results in decreased ... Cited by 17 - Related articles - All 11 versions
- ►endojournals.org K Tsuchiya, H Sakai, N Suzuki, F Iwashima, T … - Endocrinology, 2007 - Endocrine Soc Genetic deletion of inducible nitric oxide synthase (NOS) in mice has been shown
to improve high-fat diet (HFD)-induced insulin resistance. However, a
pathophysiological role of endogenous nitric oxide (NO) in obesity-related ... Cited by 14 - Related articles - BL Direct - All 3 versions
- ►physiology.org A Dey, AA Caro, AI Cederbaum - American Journal of Physiology- Gastrointestinal and …, 2007 - Am Physiological Soc Pyrazole treatment to induce cytochrome P-450 2E1 (CYP2E1) was recently shown to
cause liver injury in ob/ob mice but not in lean mice. The present study
investigated the effects of S-adenosyl-L-methionine (SAM) on the CYP2E1- ... Cited by 9 - Related articles - BL Direct - All 4 versions
- ►nih.gov K Stadler, MG Bonini, S Dallas, JJ Jiang, R … - Free Radical Biology and Medicine, 2008 - Elsevier Free radical production is implicated in the pathogenesis of diabetes mellitus,
where several pathways and different mechanisms were suggested in the
pathophysiology of the complications. In this study, we used electron ... Cited by 7 - Related articles - All 5 versions
N Bashan, J Kovsan, I Kachko, H Ovadia, A … - Physiological reviews, 2009 - Am Physiological Soc Regulated production of reactive oxygen species (ROS)/reactive nitrogen species
(RNS) adequately balanced by antioxidant systems is a prerequisite for the
participation of these active substances in physiological processes, ... Cited by 6 - Related articles - All 3 versions
