- ►jbc.org JY Lee, M Ristow, X Lin, MF White, MA Magnuson, … - Journal of Biological …, 2006 - ASBMB The Cre/loxP recombinase system for performing conditional gene targeting experiments has
been very useful in exploring genetic pathways that control both the development and function
of pancreatic -cells. One particular line of transgenic mice (B6.Cg-Tg(Ins2-cre)25Mgn/J), ... Cited by 52 - Related articles - BL Direct - All 8 versions
CW Hay, K Docherty - Diabetes, 2006 - Am Diabetes Assoc DNA sequences that regulate expression of the insulin gene are located within a region spanning
∼400 bp that flank the transcription start site. This region, the insulin promoter, contains a number
of cis-acting elements that bind transcription factors, some of which are expressed only in ... Cited by 31 - Related articles - BL Direct - All 9 versions
SD Bailey, JC Loredo-Osti, P Lepage, J Faith, J … - Diabetes, 2006 - Am Diabetes Assoc The adipokine visfatin (PBEF1) exhibits insulin-mimetic effects and correlates strongly with visceral
adiposity. We sequenced visfatin gene exons and 1,480 bp of the promoter in 23 individuals,
including 18 individuals from the Quebec Family Study (QFS) with varying degrees of ... Cited by 24 - Related articles - BL Direct - All 8 versions
- ►ucdavis.edu [PDF] G Cortopassi, S Danielson, M Alemi, SS Zhan, W Tong, … - Mitochondrion, 2006 - Elsevier Mutations in gene products expressed in the mitochondrion cause a nuclear transcriptional response
that leads to neurological disease. To examine the extent to which the transcriptional profile was
shared among 5 mitochondrial diseases (LHON, FRDA, MELAS, KSS, and NARP), we ... Cited by 12 - Related articles - All 3 versions
SA Myers, SCM Wang, GEO Muscat - Journal of Biological Chemistry, 2006 - ASBMB The chicken ovalbumin upstream promoter-transcription factors (COUP-TFs) are "orphan" members
of the nuclear hormone receptor (NR) superfamily. COUP-TFs are involved in organogenesis
and neurogenesis. However, their role in skeletal muscle (and other major mass tissues) ... Cited by 10 - Related articles - All 7 versions
- ►physiology.org AG Smith, GEO Muscat - American Journal of Physiology- Cell …, 2006 - Am Physiological Soc Nuclear hormone receptors (NRs) are ligand-dependent transcription factors that bind DNA and
translate physiological signals into gene regulation. The therapeutic utility of NRs is underscored
by the diversity of drugs created to manage dysfunctional hormone signaling in the ... Cited by 8 - Related articles - BL Direct - All 3 versions
D Pomplun, S Florian, T Schulz, AF Pfeiffer, M … - … and metabolic research …, 2007 - ncbi.nlm.nih.gov Tissue-specific disruption of genes by targeted expression of Cre recombinase in insulin-producing
cells has been widely used to explore pathways involved in regulation of pancreatic beta-cell
mass. One particular line of transgenic mice [B6.Cg-Tg(Ins2-cre)25Mgn/J], commonly ... Cited by 4 - Related articles - BL Direct - All 4 versions
BG Hoffman, KL Williams, AH Tien, V Lu, TR de … - Genes and Immunity, 2005 - nature.com We constructed and analyzed six serial analysis of gene expression (SAGE) libraries to identify
genes with previously uncharacterized roles in spleen or thymus development. A total of 625
070 tags were sequenced from the three spleen (embryonic day (E)15.5, E16.5 and adult) ... Cited by 3 - Related articles - BL Direct - All 3 versions
- ►nih.gov A Perilhou, C Tourrel-Cuzin, P Zhang, I … - Molecular and Cellular …, 2008 - Am Soc Microbiol Pancreatic islet beta cell differentiation and function are dependent upon a group of transcription
factors that maintain the expression of key genes and suppress others. Knockout mice with the
heterozygous deletion of the gene for chicken ovalbumin upstream promoter-transcription ... Cited by 2 - Related articles - All 6 versions
- ►nih.gov A Perilhou, C Tourrel-Cuzin, I Kharroubi, C … - Molecular and Cellular …, 2008 - Am Soc Microbiol COUP-TFII has an important role in regulating metabolism in vivo. We showed this previously
by deleting COUP-TFII from pancreatic beta cells in heterozygous mutant mice, which led to abnormal
insulin secretion. Here, we report that COUP-TFII expression is reduced in the pancreas ... Cited by 2 - Related articles - All 5 versions
